Inflammatory microglia correlate with impaired oligodendrocyte maturation in multiple sclerosis

Inflammatory microglia correlate with impaired oligodendrocyte maturation in multiple sclerosis

IntroductionRemyelination of demyelinated axons can occur as an endogenous repair mechanism in multiple sclerosis (MS), but its efficacy varies between both MS individuals and lesions. The molecular and cellular mechanisms that drive remyelination remain poorly understood. Here, we studied the relat...

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Bibliographic Details
Main Authors: J. Q. Alida Chen, Dennis D. Wever, Niamh B. McNamara, Morjana Bourik, Joost Smolders, Jörg Hamann, Inge Huitinga
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
remyelination
inflammation
microglia
oligodendrocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1522381/full
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