FLNA, a disulfidptosis-related gene, modulates tumor immunity and progression in colorectal cancer

FLNA, a disulfidptosis-related gene, modulates tumor immunity and progression in colorectal cancer

Abstract Background Disulfidptosis represents a novel type of regulated cell death induced by excessively high intracellular levels of cystine. Targeting disulfide imbalance is considered a promising treatment approach for colorectal cancer (CRC). However, the involvement of disulfidptosis in CRC im...

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Main Authors: Qiong Li, Renhong Huang, Lingling Lv, Haifeng Ying, Yuan Wu, YuQing Huang, Yuxi Li, Wen Ma, Xiaoshuang Liu, Qinghui Meng, Fengying Xing, Yan Shen, Lan Zheng
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cellular & Molecular Biology Letters
Subjects:
Disulfidptosis
Filamin A
Epithelial mesenchymal transition
Glucose transporter 1
Immunotherapy
Colorectal cancer
Online Access:https://doi.org/10.1186/s11658-025-00761-3
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