DCAF13-mediated K63-linked ubiquitination of RNA polymerase I promotes uncontrolled proliferation in Breast Cancer

DCAF13-mediated K63-linked ubiquitination of RNA polymerase I promotes uncontrolled proliferation in Breast Cancer

Abstract Hyperactivation of ribosome biogenesis (RiBi) drives cancer progression, yet the role of RiBi-associated proteins (RiBPs) in breast cancer (BC) is underexplored. In this study, we perform a comprehensive multi-omics analysis and reveal that assembly and maturation factors (AMFs), a subclass...

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Main Authors: Zhi-Zhi Yang, Bing Yang, Haiyan Yan, Xingyu Ma, Bin Tian, Bingqi Zheng, Yong-Xian Chen, Yi-Ming Dong, Jinsi Deng, Ziling Zhan, Yanmei Shi, Jing Yuan Zhang, Daning Lu, Jie-Hua He, Yin Zhang, KaiShun Hu, Shuang Zhu, Keda Zhou, Yu-Chan Zhang, Yiqing Zheng, Dong Yin, Jian-You Liao
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-55851-9
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