Distinctive grade based on Ki67 index and immune microenvironment of metastatic pancreatic neuroendocrine tumors responding to capecitabine plus temozolomide

Distinctive grade based on Ki67 index and immune microenvironment of metastatic pancreatic neuroendocrine tumors responding to capecitabine plus temozolomide

Abstract Background Ki67 index changes during the treatment of metastatic pancreatic neuroendocrine tumor (PanNET) treatment. The study aimed to detect alterations of grade based on Ki67 index and immune microenvironment in PanNET responding to capecitabine/temozolomide (CapTem). Method Retrospectiv...

Full description

Saved in:

Bibliographic Details
Main Authors:	Heli Gao, Wuhu Zhang, Zheng Li, Wensheng Liu, Mengqi Liu, Qifeng Zhuo, Yihua Shi, Wenyan Xu, Chenjie Zhou, Yi Qin, Jin Xu, Jie Chen, Xianjun Yu, Xiaowu Xu, Shunrong Ji
Format:	Article
Language:	English
Published:	BMC 2024-11-01
Series:	BMC Cancer
Subjects:	Pancreatic neuroendocrine tumor Ki67 index Capecitabine/temozolomide Upgrading Tumor microenvironment
Online Access:	https://doi.org/10.1186/s12885-024-13117-5
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Immunohistochemical Staining Properties of Osteopontin and Ki-67 in Feline Meningiomas
by: Gabriele Gradner, et al.
Published: (2024-11-01)

P63 and Ki-67 expression in radicular cyst
by: Mohammed Amjed Alsaegh, et al.
Published: (2023-09-01)

The importance of Ki-67 proliferation index in small cell lung cancer
by: Seda Beyhan Sağmen, et al.
Published: (2025-01-01)

A deep learning model to predict Ki-67 positivity in oral squamous cell carcinoma
by: Francesco Martino, et al.
Published: (2024-12-01)

Expression of Ki-67 in Oral Lichen Planus: A Systematic Review and Meta-Analysis
by: Ayla Bahramian, et al.
Published: (2024-12-01)

Prediction of Ki-67 expression and malignant potential in gastrointestinal stromal tumors: novel models based on CE-CT and serological indicators
by: Jun Tian, et al.
Published: (2024-11-01)

Prediction of Ki-67 expression in gastric gastrointestinal stromal tumors using histogram analysis of monochromatic and iodine images derived from spectral CT
by: Xianwang Liu, et al.
Published: (2024-12-01)

Multi-institutional evaluation comparing guidance from International Ki67 Working Group vs National Health Commission of China on immunohistochemistry-based Ki67 assessment alongside the Quantitative Dot Blot method
by: Yin Wang, et al.
Published: (2025-01-01)

Investigation of Ki-67 and Clinical Outcome in Feline Nasal Adenocarcinoma Treated Using Hypofractionated Radiotherapy
by: Premkamon Aonta, et al.
Published: (2024-12-01)

MCM3 and Ki67 proliferation markers in odontogenic cysts and ameloblastoma
by: Zohreh Jaafari-Ashkavandi, et al.
Published: (2019-01-01)

Küçük Hücre Dışı Akciğer Karsinomlarında Biyolojik Davranışın Belirlenmesinde p53 ve Ki-67 Ekspresyonunun Değeri
by: Ceyhan Uğurluoğlu, et al.
Published: (2020-12-01)

The Impact of p53 and Ki67 Expression in Endometrial Cancer and its Effect on Survival
by: Zekiye Sahin, et al.
Published: (2022-03-01)

Clinicopathological importance of immunohistochemical expression of OCT4, c-MYC and Ki-67 in colorectal cancer
by: Rabia Hursitoglu, et al.
Published: (2024-12-01)

Immunoexpression of P16 and Ki 67 in oral squamous cell carcinoma: Association with clinicopathological parameters.
by: Shadan Mohamad Omer, et al.
Published: (2020-12-01)

A Multicenter Physician Survey Evaluating the Use of Ki-67 in Breast Cancer Management in Canada
by: Jennifer Leigh, et al.
Published: (2024-10-01)

Quantitative immunohistochemistry analysis of breast Ki67 based on artificial intelligence
by: Wang Wenhui, et al.
Published: (2024-12-01)

Improving the accuracy of reporting Ki-67 IHC by using an AI tool
by: Sahil Ajit Saraf, et al.
Published: (2024-11-01)

Does altered Ki67 expression in recurrent membranous basal cell adenoma point toward the need for reclassification?
by: Dhinakaran Paranchodi, et al.
Published: (2024-09-01)

The value of multiparametric MRI radiomics and machine learning in predicting preoperative Ki-67 expression level in breast cancer
by: Yan Lu, et al.
Published: (2025-01-01)

Associated adverse outcomes with tumor treating fields when combined to temozolomide versus temozolomide alone for the treatment of glioblastoma: a meta-analysis of randomized trials
by: Yuanyuan Chen, et al.
Published: (2025-02-01)

Assessment of Ki-67 expression in cases of prostatic carcinoma and its correlation with clinical outcomes
by: Sumaira Siddiqui
Published: (2024-04-01)

CD34 and Ki-67 Immunoexpression in Periapical Granulomas: Implications for Angiogenesis and Cellular Proliferation
by: Ciprian Roi, et al.
Published: (2024-10-01)

Study of morphology with assessment of expression of proliferation marker Ki67 antigen and P53 protein in lesions of gall bladder
by: Ojasvi Ramesh, et al.
Published: (2024-04-01)

Correlation between Ki-67 labeling index and mitotic index in Head and neck squamous cell carcinoma
by: Das C. K Deepa, et al.
Published: (2024-12-01)

The Correlation Between the Natural Course, Pathologic Properties With Ki‐67 Expression in Lung Adenocarcinoma Presenting as Ground‐Glass Nodules
by: Shaohui Huang, et al.
Published: (2024-11-01)

Analysis of p53- immunoreactivity in astrocytic brain tumors
by: Shinkarenko T.V., et al.
Published: (2016-12-01)

Analysis of p53- immunoreactivity in astrocytic brain tumors.
by: T. V. Shinkarenko, et al.
Published: (2016-12-01)

Correlation of mitosis obtained by using 1% crystal violet stain with Ki67LI in histological grades of oral squamous cell carcinoma
by: Priyanka Kadoo, et al.
Published: (2018-09-01)

Aberrant Ki‐67 expression through 3′UTR alternative polyadenylation in breast cancers
by: Hong Yan, et al.
Published: (2018-03-01)

An MRI-based radiomics nomogram for preoperative prediction of Ki-67 index in nasopharyngeal carcinoma: a two-center study
by: Yao Wang, et al.
Published: (2024-12-01)

Integrating traditional biomarkers and emerging predictors to assess neoadjuvant chemotherapy efficacy in breast cancer: a multifactorial analysis of Ki-67, CDK4, EGFR, TILs and ctDNA
by: Tianzhao Du, et al.
Published: (2024-12-01)

The combined assessment of p16INK4a and Mib/Ki-67 in oral squamous cell carcinoma
by: Maximilian Richter, et al.
Published: (2024-11-01)

Comparative analysis of Ki-67 labeling index morphometry using deep learning, conventional image analysis, and manual counting
by: Mohammad Rizwan Alam, et al.
Published: (2025-01-01)

Factors involved in maintaining Karnofsky Performance Status (≥ 50%) in glioblastoma, IDH-wildtype patients treated with temozolomide and radiotherapy
by: Shigeo Ohba, et al.
Published: (2025-01-01)

Ki-67 and CDK1 control the dynamic association of nuclear lipids with mitotic chromosomes
by: Hsiao-Tang Hu, et al.
Published: (2025-01-01)

Nomogram based on the neutrophil-to-lymphocyte ratio and MR diffusion quantitative parameters for predicting Ki67 expression in hepatocellular carcinoma from a prospective study
by: Yu-chen Wei, et al.
Published: (2024-12-01)

Stepwise to clarify differentiation between pleomorphic xanthoastrocytoma and giant cell glioblastoma using p53, CD34 and KI67; clinicopathological hospital based study
by: Abdelhakeem A. Essa, et al.
Published: (2024-11-01)

A novel scoring system proposal to guide treatment of dogs with hepatoid gland tumors
by: Lorella Maniscalco, et al.
Published: (2025-02-01)

Management of severe capecitabine-induced corneal toxicity
by: Mathieu Heyvaert, et al.
Published: (2024-12-01)

Inmunolocalización de citoqueratina 14, 19 y Ki-67 en el epitelio de pacientes con agrandamiento gingival
by: Víctor Simancas-Escorcia, et al.
Published: (2023-01-01)