Nocardiose disseminada
Nocardiosis, caused by various species of Nocardia, poses diagnostic and therapeutic challenges due to its diverse clinical presentations that often mimic other infections and malignancies. We present the case of a 72-year-old woman with a history of autoimmune hepatitis and diabetes mellitus (DM) w...
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| Format: | Article |
| Language: | English |
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Sociedade Galega de Medicina Interna
2025-01-01
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| Series: | Galicia Clínica |
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| Online Access: | https://galiciaclinica.info/publicacion.asp?f=4162 |
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| _version_ | 1841536652429754368 |
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| author | Tiago Costa Luís Rocha Luciana Silva Inês Rato Sara Pinto |
| author_facet | Tiago Costa Luís Rocha Luciana Silva Inês Rato Sara Pinto |
| author_sort | Tiago Costa |
| collection | DOAJ |
| description | Nocardiosis, caused by various species of Nocardia, poses diagnostic and therapeutic challenges due to its diverse clinical presentations that often mimic other infections and malignancies. We present the case of a 72-year-old woman with a history of autoimmune hepatitis and diabetes mellitus (DM) who initially presented with fever, headaches, and confusion. Extensive investigations revealed an ischemic lesion in the central nervous system (CNS) attributed to vasculitis.
Two months later, she returned with literal paraphasia, ocular symptoms (red eye and retro-orbital pain), and fever. Despite negative blood cultures, Nocardia cyriacigeorgica was isolated from vitreous humor and lung tissue, confirming the diagnosis of disseminated nocardiosis. A rigorous treatment regimen, including trimethoprim/sulfamethoxazole (TMP/SMX), Meropenem, and Linezolid, led to significant improvement.
This case underscores the diagnostic complexity of Nocardiosis, emphasizing the need for early and precise diagnosis, multidisciplinary care, and prolonged treatment in severe cases. Further research is required to optimize therapeutic protocols, particularly in CNS-involved Nocardiosis. |
| format | Article |
| id | doaj-art-07b80685e86f4e6e946b92727dd02e9a |
| institution | Kabale University |
| issn | 0304-4866 1989-3922 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Sociedade Galega de Medicina Interna |
| record_format | Article |
| series | Galicia Clínica |
| spelling | doaj-art-07b80685e86f4e6e946b92727dd02e9a2025-01-14T11:59:29ZengSociedade Galega de Medicina InternaGalicia Clínica0304-48661989-39222025-01-01853313310.22546/74/41624162Nocardiose disseminadaTiago Costa0Luís Rocha1Luciana Silva2Inês Rato3Sara Pinto4Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de GaiaCentro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de GaiaCentro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de GaiaCentro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de GaiaCentro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de GaiaNocardiosis, caused by various species of Nocardia, poses diagnostic and therapeutic challenges due to its diverse clinical presentations that often mimic other infections and malignancies. We present the case of a 72-year-old woman with a history of autoimmune hepatitis and diabetes mellitus (DM) who initially presented with fever, headaches, and confusion. Extensive investigations revealed an ischemic lesion in the central nervous system (CNS) attributed to vasculitis. Two months later, she returned with literal paraphasia, ocular symptoms (red eye and retro-orbital pain), and fever. Despite negative blood cultures, Nocardia cyriacigeorgica was isolated from vitreous humor and lung tissue, confirming the diagnosis of disseminated nocardiosis. A rigorous treatment regimen, including trimethoprim/sulfamethoxazole (TMP/SMX), Meropenem, and Linezolid, led to significant improvement. This case underscores the diagnostic complexity of Nocardiosis, emphasizing the need for early and precise diagnosis, multidisciplinary care, and prolonged treatment in severe cases. Further research is required to optimize therapeutic protocols, particularly in CNS-involved Nocardiosis.https://galiciaclinica.info/publicacion.asp?f=4162nocardiainmunodepresióninfección del sistema nervioso centralvasculitis |
| spellingShingle | Tiago Costa Luís Rocha Luciana Silva Inês Rato Sara Pinto Nocardiose disseminada Galicia Clínica nocardia inmunodepresión infección del sistema nervioso central vasculitis |
| title | Nocardiose disseminada |
| title_full | Nocardiose disseminada |
| title_fullStr | Nocardiose disseminada |
| title_full_unstemmed | Nocardiose disseminada |
| title_short | Nocardiose disseminada |
| title_sort | nocardiose disseminada |
| topic | nocardia inmunodepresión infección del sistema nervioso central vasculitis |
| url | https://galiciaclinica.info/publicacion.asp?f=4162 |
| work_keys_str_mv | AT tiagocosta nocardiosedisseminada AT luisrocha nocardiosedisseminada AT lucianasilva nocardiosedisseminada AT inesrato nocardiosedisseminada AT sarapinto nocardiosedisseminada |