Putative Predictive Value of Etiological and Clinical Factors on Sperm Retrieval Outcomes in Non-Obstructive Azoospermia Using Micro-TESE: A Retrospective Study
Non-obstructive azoospermia (NOA) is a condition of testicular failure caused by various factors. To retrieve sperm in NOA patients, microdissection testicular sperm extraction (micro-TESE) is a highly effective technique. The present study aimed to evaluate successful sperm retrieval (SSR) in NOA p...
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SAGE Publishing
2025-05-01
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| Series: | American Journal of Men's Health |
| Online Access: | https://doi.org/10.1177/15579883251338483 |
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| author | Samaneh Harimi Mohsen Ahrari Ali Sadeghi Samane Eskandarian Safiyehsadat Heydari Farzaneh Fesahat |
| author_facet | Samaneh Harimi Mohsen Ahrari Ali Sadeghi Samane Eskandarian Safiyehsadat Heydari Farzaneh Fesahat |
| author_sort | Samaneh Harimi |
| collection | DOAJ |
| description | Non-obstructive azoospermia (NOA) is a condition of testicular failure caused by various factors. To retrieve sperm in NOA patients, microdissection testicular sperm extraction (micro-TESE) is a highly effective technique. The present study aimed to evaluate successful sperm retrieval (SSR) in NOA patients across different etiologies in the Iranian population to identify predictive factors. This retrospective analysis included 566 NOA patients undergoing micro-TESE from 2018 to 2023, with 58 histories of Cryptorchidism, 40 Klinefelter syndrome (KS), 6 Y chromosomal microdeletions (YCMDs), 6 histories of chemotherapy, 5 mumps orchitis, and 451 patients with idiopathic reasons. The overall SSR was 43.2%, with a significantly lower SSR in the KS group ( p = .012). Patients with higher average ages tended to have higher SSR rates, especially in the idiopathic group. Hormone levels differed among the groups, with higher follicle-stimulating hormone and luteinizing hormone levels in the YCMDs group, higher testosterone levels in the idiopathic and Cryptorchidism groups, and higher prolactin levels in the KS group. There were no significant differences in other clinical characteristics between the SSR and sperm retrieval failure groups, except for a positive relationship between prolactin levels and SSR rates in the KS group ( r = .45, p = .003). Our data underscores that underlying etiology and genetic background may reveal more valuable predictive value than age, hormone levels, and testicular volume. This finding suggests that no patient with NOA should be deprived of micro-TESE based on candidate predictors of SSR presented to date. |
| format | Article |
| id | doaj-art-07b4e001d7aa47cf8c9bf8a3bef3fc0c |
| institution | Kabale University |
| issn | 1557-9891 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | American Journal of Men's Health |
| spelling | doaj-art-07b4e001d7aa47cf8c9bf8a3bef3fc0c2025-08-20T03:48:18ZengSAGE PublishingAmerican Journal of Men's Health1557-98912025-05-011910.1177/15579883251338483Putative Predictive Value of Etiological and Clinical Factors on Sperm Retrieval Outcomes in Non-Obstructive Azoospermia Using Micro-TESE: A Retrospective StudySamaneh Harimi0Mohsen Ahrari1Ali Sadeghi2Samane Eskandarian3Safiyehsadat Heydari4Farzaneh Fesahat5Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IranAndrology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Yazd Province, IranDepartment of Surgical Technology, Faculty of Paramedical, Shahid Sadoughi University of Medical Sciences, Yazd, Yazd Province, IranDepartment of Genetic, Faculty of Basic Science, Shahrekord Branch Islamic Azad University, Shahrekord, Chaharmahal and Bakhtiari Province, IranResearch Center for Health Technology Assessment and Medical Informatics, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Yazd Province, IranReproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IranNon-obstructive azoospermia (NOA) is a condition of testicular failure caused by various factors. To retrieve sperm in NOA patients, microdissection testicular sperm extraction (micro-TESE) is a highly effective technique. The present study aimed to evaluate successful sperm retrieval (SSR) in NOA patients across different etiologies in the Iranian population to identify predictive factors. This retrospective analysis included 566 NOA patients undergoing micro-TESE from 2018 to 2023, with 58 histories of Cryptorchidism, 40 Klinefelter syndrome (KS), 6 Y chromosomal microdeletions (YCMDs), 6 histories of chemotherapy, 5 mumps orchitis, and 451 patients with idiopathic reasons. The overall SSR was 43.2%, with a significantly lower SSR in the KS group ( p = .012). Patients with higher average ages tended to have higher SSR rates, especially in the idiopathic group. Hormone levels differed among the groups, with higher follicle-stimulating hormone and luteinizing hormone levels in the YCMDs group, higher testosterone levels in the idiopathic and Cryptorchidism groups, and higher prolactin levels in the KS group. There were no significant differences in other clinical characteristics between the SSR and sperm retrieval failure groups, except for a positive relationship between prolactin levels and SSR rates in the KS group ( r = .45, p = .003). Our data underscores that underlying etiology and genetic background may reveal more valuable predictive value than age, hormone levels, and testicular volume. This finding suggests that no patient with NOA should be deprived of micro-TESE based on candidate predictors of SSR presented to date.https://doi.org/10.1177/15579883251338483 |
| spellingShingle | Samaneh Harimi Mohsen Ahrari Ali Sadeghi Samane Eskandarian Safiyehsadat Heydari Farzaneh Fesahat Putative Predictive Value of Etiological and Clinical Factors on Sperm Retrieval Outcomes in Non-Obstructive Azoospermia Using Micro-TESE: A Retrospective Study American Journal of Men's Health |
| title | Putative Predictive Value of Etiological and Clinical Factors on Sperm Retrieval Outcomes in Non-Obstructive Azoospermia Using Micro-TESE: A Retrospective Study |
| title_full | Putative Predictive Value of Etiological and Clinical Factors on Sperm Retrieval Outcomes in Non-Obstructive Azoospermia Using Micro-TESE: A Retrospective Study |
| title_fullStr | Putative Predictive Value of Etiological and Clinical Factors on Sperm Retrieval Outcomes in Non-Obstructive Azoospermia Using Micro-TESE: A Retrospective Study |
| title_full_unstemmed | Putative Predictive Value of Etiological and Clinical Factors on Sperm Retrieval Outcomes in Non-Obstructive Azoospermia Using Micro-TESE: A Retrospective Study |
| title_short | Putative Predictive Value of Etiological and Clinical Factors on Sperm Retrieval Outcomes in Non-Obstructive Azoospermia Using Micro-TESE: A Retrospective Study |
| title_sort | putative predictive value of etiological and clinical factors on sperm retrieval outcomes in non obstructive azoospermia using micro tese a retrospective study |
| url | https://doi.org/10.1177/15579883251338483 |
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