Evaluation of efficacy of Hemoporfin-PDT in the treatment of PWS birthmarks of young children previously received PDL treatment
Background: Hemoporfin-mediated photodynamic therapy (Hemoporfin-PDT) is considered a safe and effective treatment for port-wine stains (PWS). This study aims to investigate the influence of prior pulse dye laser (PDL) treatments history on the effectiveness of Hemoporfin-PDT in young children aged...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024004551 |
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| author | Yawen Wang Jun Zhou Chunzhi Qi Youbao Li Die Hu Rongrui Zhang Shengzhi Mu Zhao Wang Songmei Geng Weihui Zeng Jing Liu |
| author_facet | Yawen Wang Jun Zhou Chunzhi Qi Youbao Li Die Hu Rongrui Zhang Shengzhi Mu Zhao Wang Songmei Geng Weihui Zeng Jing Liu |
| author_sort | Yawen Wang |
| collection | DOAJ |
| description | Background: Hemoporfin-mediated photodynamic therapy (Hemoporfin-PDT) is considered a safe and effective treatment for port-wine stains (PWS). This study aims to investigate the influence of prior pulse dye laser (PDL) treatments history on the effectiveness of Hemoporfin-PDT in young children aged 1–3 years with PWS. Methods: Data was gathered for individuals with PWS aged 1–3 years who received two or more Hemoporfin-PDT treatments. The study population was stratified into two groups: Cohort 1 (No PDL) comprised patients without a history of PDL treatment, while Cohort 2 (Prior PDL) consisted of patients with a history of PDL treatment. An analysis was conducted to investigate the relationship between treatment efficacy and variables including gender, age, location, and type of PWS. Results: There were a total of 220 cases in the No PDL group and 53 cases in the Prior PDL group. It was observed that prior PDL treatment history did not impact the efficacy of Hemoporfin-PDT in treating PWS among young children. Both the type and location of PWS significantly influence the clinical effectiveness of Hemoporfin-PDT for PWS (P = 0.040, P < 0.001), while gender and age show no association with treatment outcomes (P > 0.05). Notably, the peripheral face might be an independent influencing factor for high efficacy of Hemoporfin-PDT of the facial regions (P < 0.05). Conclusion: Previous PDL treatment history does not impact the effectiveness of Hemoporfin-PDT therapy in young children with PWS. |
| format | Article |
| id | doaj-art-07b1b15f303c4f7d9342386300909d93 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-07b1b15f303c4f7d9342386300909d932024-12-13T10:56:18ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-12-0150104418Evaluation of efficacy of Hemoporfin-PDT in the treatment of PWS birthmarks of young children previously received PDL treatmentYawen Wang0Jun Zhou1Chunzhi Qi2Youbao Li3Die Hu4Rongrui Zhang5Shengzhi Mu6Zhao Wang7Songmei Geng8Weihui Zeng9Jing Liu10Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, ChinaDepartment of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, ChinaDepartment of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, ChinaDepartment of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, ChinaDepartment of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, ChinaSchool of Life Sciences and Technology, Institute of Biomedical Photonics and Sensing, Xi'an Jiaotong University, ChinaDepartment of Burn and Plastic Surgery, Shaanxi Provincial People's Hospital, ChinaDepartment of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, ChinaDepartment of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, ChinaDepartment of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China; Corresponding authors.Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China; Corresponding authors.Background: Hemoporfin-mediated photodynamic therapy (Hemoporfin-PDT) is considered a safe and effective treatment for port-wine stains (PWS). This study aims to investigate the influence of prior pulse dye laser (PDL) treatments history on the effectiveness of Hemoporfin-PDT in young children aged 1–3 years with PWS. Methods: Data was gathered for individuals with PWS aged 1–3 years who received two or more Hemoporfin-PDT treatments. The study population was stratified into two groups: Cohort 1 (No PDL) comprised patients without a history of PDL treatment, while Cohort 2 (Prior PDL) consisted of patients with a history of PDL treatment. An analysis was conducted to investigate the relationship between treatment efficacy and variables including gender, age, location, and type of PWS. Results: There were a total of 220 cases in the No PDL group and 53 cases in the Prior PDL group. It was observed that prior PDL treatment history did not impact the efficacy of Hemoporfin-PDT in treating PWS among young children. Both the type and location of PWS significantly influence the clinical effectiveness of Hemoporfin-PDT for PWS (P = 0.040, P < 0.001), while gender and age show no association with treatment outcomes (P > 0.05). Notably, the peripheral face might be an independent influencing factor for high efficacy of Hemoporfin-PDT of the facial regions (P < 0.05). Conclusion: Previous PDL treatment history does not impact the effectiveness of Hemoporfin-PDT therapy in young children with PWS.http://www.sciencedirect.com/science/article/pii/S1572100024004551Hemoporfin-PDTYoung childrenRetrospective cohort studyInfluential factorEfficacyPort wine stain |
| spellingShingle | Yawen Wang Jun Zhou Chunzhi Qi Youbao Li Die Hu Rongrui Zhang Shengzhi Mu Zhao Wang Songmei Geng Weihui Zeng Jing Liu Evaluation of efficacy of Hemoporfin-PDT in the treatment of PWS birthmarks of young children previously received PDL treatment Photodiagnosis and Photodynamic Therapy Hemoporfin-PDT Young children Retrospective cohort study Influential factor Efficacy Port wine stain |
| title | Evaluation of efficacy of Hemoporfin-PDT in the treatment of PWS birthmarks of young children previously received PDL treatment |
| title_full | Evaluation of efficacy of Hemoporfin-PDT in the treatment of PWS birthmarks of young children previously received PDL treatment |
| title_fullStr | Evaluation of efficacy of Hemoporfin-PDT in the treatment of PWS birthmarks of young children previously received PDL treatment |
| title_full_unstemmed | Evaluation of efficacy of Hemoporfin-PDT in the treatment of PWS birthmarks of young children previously received PDL treatment |
| title_short | Evaluation of efficacy of Hemoporfin-PDT in the treatment of PWS birthmarks of young children previously received PDL treatment |
| title_sort | evaluation of efficacy of hemoporfin pdt in the treatment of pws birthmarks of young children previously received pdl treatment |
| topic | Hemoporfin-PDT Young children Retrospective cohort study Influential factor Efficacy Port wine stain |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024004551 |
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