Excitatory neuron-prone prion propagation and excitatory neuronal loss in prion-infected mice

Excitatory neuron-prone prion propagation and excitatory neuronal loss in prion-infected mice

The accumulation of a disease-specific isoform of prion protein (PrPSc) and histopathological lesions, such as neuronal loss, are unevenly distributed in the brains of humans and animals affected with prion diseases. This distribution varies depending on the diseases and/or the combinations of prion...

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Bibliographic Details
Main Authors: Temuulen Erdenebat, Yusuke Komatsu, Nozomi Uwamori, Misaki Tanaka, Takashi Hoshika, Takeshi Yamasaki, Ayano Shimakura, Akio Suzuki, Toyotaka Sato, Motohiro Horiuchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
prion
PrPSc
excitatory neuron
inhibitory neuron
glutamatergic neuron
GABAergic neuron
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1498142/full
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