Parvovirus B19-triggered acute hemolytic anemia and thrombocytopenia in a child with Evans syndrome
Background: Human parvovirus B19 (HPV-B19) is the etiologic agent of erythema infectiosum, of transient aplastic crises in individuals with underlying chronic hemolytic disorders, and of chronic pure red cell aplasia in immunocompromised individuals. Case report. We describe a 14-year-old girl with...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2018-03-01
|
| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | https://www.mjhid.org/index.php/mjhid/article/view/3213 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846098241000570880 |
|---|---|
| author | ELPIS MANTADAKIS |
| author_facet | ELPIS MANTADAKIS |
| author_sort | ELPIS MANTADAKIS |
| collection | DOAJ |
| description | Background: Human parvovirus B19 (HPV-B19) is the etiologic agent of erythema infectiosum, of transient aplastic crises in individuals with underlying chronic hemolytic disorders, and of chronic pure red cell aplasia in immunocompromised individuals.
Case report. We describe a 14-year-old girl with long-standing Evans syndrome, who presented with severe anemia, reticulocytopenia and thromocytopenia. A bone marrow aspirate revealed severe erythroid hypoplasia along with presence of giant pronormoblasts, while serological studies and real-time PCR of whole blood were positive for acute parvovirus B19 infection. The patient was initially managed with corticosteroids, but both cytopenias resolved only after administration of intravenous gamma globulin 0.8g/kg.
Conclusion: Acute parvovirus B19 infection should be suspected in patients with immunologic diseases, who present with reticulocytopenic hemolytic anemia and thrombocytopenia. In this setting, intravenous gamma globulin is effective for both cytopenias. |
| format | Article |
| id | doaj-art-077d363a0cb74bcf8b667bcdb58e5fee |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2018-03-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-077d363a0cb74bcf8b667bcdb58e5fee2025-01-02T01:33:48ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062018-03-01101e2018018e201801810.4084/mjhid.2018.0181744Parvovirus B19-triggered acute hemolytic anemia and thrombocytopenia in a child with Evans syndromeELPIS MANTADAKIS0Democritus University of Thrace Faculty of MedicineBackground: Human parvovirus B19 (HPV-B19) is the etiologic agent of erythema infectiosum, of transient aplastic crises in individuals with underlying chronic hemolytic disorders, and of chronic pure red cell aplasia in immunocompromised individuals. Case report. We describe a 14-year-old girl with long-standing Evans syndrome, who presented with severe anemia, reticulocytopenia and thromocytopenia. A bone marrow aspirate revealed severe erythroid hypoplasia along with presence of giant pronormoblasts, while serological studies and real-time PCR of whole blood were positive for acute parvovirus B19 infection. The patient was initially managed with corticosteroids, but both cytopenias resolved only after administration of intravenous gamma globulin 0.8g/kg. Conclusion: Acute parvovirus B19 infection should be suspected in patients with immunologic diseases, who present with reticulocytopenic hemolytic anemia and thrombocytopenia. In this setting, intravenous gamma globulin is effective for both cytopenias.https://www.mjhid.org/index.php/mjhid/article/view/3213Autoimmune hemolytic anemia, Evans syndrome, parvovirus B19, red cell aplasia, thrombocytopenia |
| spellingShingle | ELPIS MANTADAKIS Parvovirus B19-triggered acute hemolytic anemia and thrombocytopenia in a child with Evans syndrome Mediterranean Journal of Hematology and Infectious Diseases Autoimmune hemolytic anemia, Evans syndrome, parvovirus B19, red cell aplasia, thrombocytopenia |
| title | Parvovirus B19-triggered acute hemolytic anemia and thrombocytopenia in a child with Evans syndrome |
| title_full | Parvovirus B19-triggered acute hemolytic anemia and thrombocytopenia in a child with Evans syndrome |
| title_fullStr | Parvovirus B19-triggered acute hemolytic anemia and thrombocytopenia in a child with Evans syndrome |
| title_full_unstemmed | Parvovirus B19-triggered acute hemolytic anemia and thrombocytopenia in a child with Evans syndrome |
| title_short | Parvovirus B19-triggered acute hemolytic anemia and thrombocytopenia in a child with Evans syndrome |
| title_sort | parvovirus b19 triggered acute hemolytic anemia and thrombocytopenia in a child with evans syndrome |
| topic | Autoimmune hemolytic anemia, Evans syndrome, parvovirus B19, red cell aplasia, thrombocytopenia |
| url | https://www.mjhid.org/index.php/mjhid/article/view/3213 |
| work_keys_str_mv | AT elpismantadakis parvovirusb19triggeredacutehemolyticanemiaandthrombocytopeniainachildwithevanssyndrome |