Factors associated with severe bacterial infection in infants between 91- and 120-days old admitted to the pediatric emergency department
Abstract Introduction Diagnosing severe bacterial infections (SBI) can be challenging, especially in infants. This study sought to identify clinical factors that could aid in predicting SBI in infants aged 91–120 days. Methods This retrospective cohort study investigated febrile infants aged 91-120...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
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| Series: | BMC Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12887-025-05764-9 |
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| Summary: | Abstract Introduction Diagnosing severe bacterial infections (SBI) can be challenging, especially in infants. This study sought to identify clinical factors that could aid in predicting SBI in infants aged 91–120 days. Methods This retrospective cohort study investigated febrile infants aged 91-120 days admitted to the pediatric emergency department (PED). This study assessed the significant predictors of clinical and laboratory data for identifying SBI in young infants. Results This study analyzed 264 febrile infants aged 91–120 days admitted to the PED. The significant factors for infants with SBI included sex, admission weight, body temperature(BT), white blood cell (WBC) count, neutrophil percentage, and C-reactive protein (CRP) level (all P < 0.05). Logistic regression analysis showed that male sex, higher BT, WBC count, and CRP levels were predictors of SBI. ROC analysis identified the useful cutoff values for predicting SBI as a BT of 39.3 °C, WBC counts of 15,500/µL, and a CRP concentration of 14.4 mg/L. Conclusions Increased BT, elevated WBC and neutrophil counts, as well as higher CRP levels, may act as predictors of SBI in infants aged 91–120 days admitted to the PED. |
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| ISSN: | 1471-2431 |