Interaction of rivaroxaban with amiodarone, verapamil and diltiazem in patients with atrial fibrillation: terra incognita
Currently there are no generally accepted guidelines for the use of rivaroxaban together with amiodarone, verapamil or diltiazem in patients with creatinine clearance (CrCl)<80 ml/min. Some researchers suggest that in renal failure amiodarone, verapamil and diltiazem contribute to a significa...
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Столичная издательская компания
2016-03-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/1208 |
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| author | S. N. Bel'diev |
| author_facet | S. N. Bel'diev |
| author_sort | S. N. Bel'diev |
| collection | DOAJ |
| description | Currently there are no generally accepted guidelines for the use of rivaroxaban together with amiodarone, verapamil or diltiazem in patients with creatinine clearance (CrCl)<80 ml/min. Some researchers suggest that in renal failure amiodarone, verapamil and diltiazem contribute to a significant increase in plasma concentrations of rivaroxaban that is accompanied by increased risk of bleeding. According to preliminary calculations, it seems rational to reduce the dose of rivaroxaban when co-administered with these drugs: to 15 mg/day in patients with ClCr 50-79 ml/min and to 10 mg/day in patients with ClCr<50 ml/min. |
| format | Article |
| id | doaj-art-077617af3df3477b821fb9e34aac39d3 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-077617af3df3477b821fb9e34aac39d32025-08-23T10:00:26ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-03-0112110110510.20996/1819-6446-2016-12-1-101-1051190Interaction of rivaroxaban with amiodarone, verapamil and diltiazem in patients with atrial fibrillation: terra incognitaS. N. Bel'diev0Tver State Medical University. Sovetskaja ul. 4, Tver, 170100 RussiaCurrently there are no generally accepted guidelines for the use of rivaroxaban together with amiodarone, verapamil or diltiazem in patients with creatinine clearance (CrCl)<80 ml/min. Some researchers suggest that in renal failure amiodarone, verapamil and diltiazem contribute to a significant increase in plasma concentrations of rivaroxaban that is accompanied by increased risk of bleeding. According to preliminary calculations, it seems rational to reduce the dose of rivaroxaban when co-administered with these drugs: to 15 mg/day in patients with ClCr 50-79 ml/min and to 10 mg/day in patients with ClCr<50 ml/min.https://www.rpcardio.online/jour/article/view/1208rivaroxaban, amiodarone, verapamil, diltiazem, drug-drug interactions, atrial fibrillation |
| spellingShingle | S. N. Bel'diev Interaction of rivaroxaban with amiodarone, verapamil and diltiazem in patients with atrial fibrillation: terra incognita Рациональная фармакотерапия в кардиологии rivaroxaban, amiodarone, verapamil, diltiazem, drug-drug interactions, atrial fibrillation |
| title | Interaction of rivaroxaban with amiodarone, verapamil and diltiazem in patients with atrial fibrillation: terra incognita |
| title_full | Interaction of rivaroxaban with amiodarone, verapamil and diltiazem in patients with atrial fibrillation: terra incognita |
| title_fullStr | Interaction of rivaroxaban with amiodarone, verapamil and diltiazem in patients with atrial fibrillation: terra incognita |
| title_full_unstemmed | Interaction of rivaroxaban with amiodarone, verapamil and diltiazem in patients with atrial fibrillation: terra incognita |
| title_short | Interaction of rivaroxaban with amiodarone, verapamil and diltiazem in patients with atrial fibrillation: terra incognita |
| title_sort | interaction of rivaroxaban with amiodarone verapamil and diltiazem in patients with atrial fibrillation terra incognita |
| topic | rivaroxaban, amiodarone, verapamil, diltiazem, drug-drug interactions, atrial fibrillation |
| url | https://www.rpcardio.online/jour/article/view/1208 |
| work_keys_str_mv | AT snbeldiev interactionofrivaroxabanwithamiodaroneverapamilanddiltiazeminpatientswithatrialfibrillationterraincognita |