A novel process driving Alzheimer's disease validated in a mouse model: Therapeutic potential

A novel process driving Alzheimer's disease validated in a mouse model: Therapeutic potential

Abstract Introduction The neuronal mechanism driving Alzheimer's disease (AD) is incompletely understood. Methods Immunohistochemistry, pharmacology, biochemistry, and behavioral testing are employed in two pathological contexts—AD and a transgenic mouse model—to investigate T14, a 14mer peptid...

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Main Authors: Susan A. Greenfield, Gregory M. Cole, Clive W. Coen, Sally Frautschy, Ram P. Singh, Marisa Mekkittikul, Sara Garcia‐Ratés, Paul Morrill, Owen Hollings, Matt Passmore, Sibah Hasan, Nikisha Carty, Silvia Bison, Laura Piccoli, Renzo Carletti, Stephano Tacconi, Anna Chalidou, Matthew Pedercini, Tim Kroecher, Hubert Astner, Philip A. Gerrard
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
5XFAD
acetylcholinesterase
alphaLISA
Alzheimer's disease
amyloid beta
basal forebrain
Online Access:https://doi.org/10.1002/trc2.12274
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https://doi.org/10.1002/trc2.12274

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