Yeast GPCR signaling reflects the fraction of occupied receptors, not the number

Abstract According to receptor theory, the effect of a ligand depends on the amount of agonist–receptor complex. Therefore, changes in receptor abundance should have quantitative effects. However, the response to pheromone in Saccharomyces cerevisiae is robust (unaltered) to increases or reductions...

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Bibliographic Details
Main Authors: Alan Bush, Gustavo Vasen, Andreas Constantinou, Paula Dunayevich, Inés Lucía Patop, Matías Blaustein, Alejandro Colman‐Lerner
Format: Article
Language:English
Published: Springer Nature 2016-12-01
Series:Molecular Systems Biology
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Online Access:https://doi.org/10.15252/msb.20166910
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