Age-specific and sex-specific reference intervals for non-fasting lipids and apolipoproteins in 7260 healthy Chinese children and adolescents measured with an Olympus AU5400 analyser: a cross-sectional study
Aims Ethnic, demographic, lifestyle, genetic and environmental factors influence lipids and apolipoproteins. The aim of this study was to establish age-specific and gender-specific reference intervals for non-fasting lipids and apolipoproteins in healthy Chinese children and adolescents.Methods This...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2019-08-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/8/e030201.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846155032522653696 |
|---|---|
| author | Junjie Liu Yanpeng Dai Enwu Yuan Yushan Li Quanxian Wang Linkai Wang Yanhua Su |
| author_facet | Junjie Liu Yanpeng Dai Enwu Yuan Yushan Li Quanxian Wang Linkai Wang Yanhua Su |
| author_sort | Junjie Liu |
| collection | DOAJ |
| description | Aims Ethnic, demographic, lifestyle, genetic and environmental factors influence lipids and apolipoproteins. The aim of this study was to establish age-specific and gender-specific reference intervals for non-fasting lipids and apolipoproteins in healthy Chinese children and adolescents.Methods This study followed the Clinical and Laboratory Standards Institute EP28-A3c guidelines. Non-fasting samples were collected from 7260 healthy Chinese children and adolescents, and they were analysed using the Olympus AU5400 analyser for: triglycerides, total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 and apolipoprotein B (ApoB). The age-related and gender-related reference intervals were partitioned using the Harris-Boyd method. The non-parametric method was used to establish the lower limit (2.5th percentile) and the upper limit (97.5th percentile) for the reference intervals. The 90% CIs for the lower and upper limits were also calculated.Results Based on the Harris-Boyd method, gender partitions were required for TC, LDL-C and ApoB. Age differences were observed for all analytes. Paediatric reference intervals were established for non-fasting lipids and apolipoproteins based on a large population of healthy children and adolescents.Conclusions Previously used reference intervals did not take age and gender into account. These age-specific and gender-specific reference intervals established in this study may contribute to improved management and assessment of paediatric diseases. |
| format | Article |
| id | doaj-art-074f04c636b2455981633d7f76a2a15f |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-074f04c636b2455981633d7f76a2a15f2024-11-26T16:45:09ZengBMJ Publishing GroupBMJ Open2044-60552019-08-019810.1136/bmjopen-2019-030201Age-specific and sex-specific reference intervals for non-fasting lipids and apolipoproteins in 7260 healthy Chinese children and adolescents measured with an Olympus AU5400 analyser: a cross-sectional studyJunjie Liu0Yanpeng Dai1Enwu Yuan2Yushan Li3Quanxian Wang4Linkai Wang5Yanhua Su61 Henan Human Sperm Bank, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China2 Department of Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China2 Department of Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China1 Henan Human Sperm Bank, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China1 Henan Human Sperm Bank, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China1 Henan Human Sperm Bank, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China1 Henan Human Sperm Bank, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaAims Ethnic, demographic, lifestyle, genetic and environmental factors influence lipids and apolipoproteins. The aim of this study was to establish age-specific and gender-specific reference intervals for non-fasting lipids and apolipoproteins in healthy Chinese children and adolescents.Methods This study followed the Clinical and Laboratory Standards Institute EP28-A3c guidelines. Non-fasting samples were collected from 7260 healthy Chinese children and adolescents, and they were analysed using the Olympus AU5400 analyser for: triglycerides, total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 and apolipoprotein B (ApoB). The age-related and gender-related reference intervals were partitioned using the Harris-Boyd method. The non-parametric method was used to establish the lower limit (2.5th percentile) and the upper limit (97.5th percentile) for the reference intervals. The 90% CIs for the lower and upper limits were also calculated.Results Based on the Harris-Boyd method, gender partitions were required for TC, LDL-C and ApoB. Age differences were observed for all analytes. Paediatric reference intervals were established for non-fasting lipids and apolipoproteins based on a large population of healthy children and adolescents.Conclusions Previously used reference intervals did not take age and gender into account. These age-specific and gender-specific reference intervals established in this study may contribute to improved management and assessment of paediatric diseases.https://bmjopen.bmj.com/content/9/8/e030201.full |
| spellingShingle | Junjie Liu Yanpeng Dai Enwu Yuan Yushan Li Quanxian Wang Linkai Wang Yanhua Su Age-specific and sex-specific reference intervals for non-fasting lipids and apolipoproteins in 7260 healthy Chinese children and adolescents measured with an Olympus AU5400 analyser: a cross-sectional study BMJ Open |
| title | Age-specific and sex-specific reference intervals for non-fasting lipids and apolipoproteins in 7260 healthy Chinese children and adolescents measured with an Olympus AU5400 analyser: a cross-sectional study |
| title_full | Age-specific and sex-specific reference intervals for non-fasting lipids and apolipoproteins in 7260 healthy Chinese children and adolescents measured with an Olympus AU5400 analyser: a cross-sectional study |
| title_fullStr | Age-specific and sex-specific reference intervals for non-fasting lipids and apolipoproteins in 7260 healthy Chinese children and adolescents measured with an Olympus AU5400 analyser: a cross-sectional study |
| title_full_unstemmed | Age-specific and sex-specific reference intervals for non-fasting lipids and apolipoproteins in 7260 healthy Chinese children and adolescents measured with an Olympus AU5400 analyser: a cross-sectional study |
| title_short | Age-specific and sex-specific reference intervals for non-fasting lipids and apolipoproteins in 7260 healthy Chinese children and adolescents measured with an Olympus AU5400 analyser: a cross-sectional study |
| title_sort | age specific and sex specific reference intervals for non fasting lipids and apolipoproteins in 7260 healthy chinese children and adolescents measured with an olympus au5400 analyser a cross sectional study |
| url | https://bmjopen.bmj.com/content/9/8/e030201.full |
| work_keys_str_mv | AT junjieliu agespecificandsexspecificreferenceintervalsfornonfastinglipidsandapolipoproteinsin7260healthychinesechildrenandadolescentsmeasuredwithanolympusau5400analyseracrosssectionalstudy AT yanpengdai agespecificandsexspecificreferenceintervalsfornonfastinglipidsandapolipoproteinsin7260healthychinesechildrenandadolescentsmeasuredwithanolympusau5400analyseracrosssectionalstudy AT enwuyuan agespecificandsexspecificreferenceintervalsfornonfastinglipidsandapolipoproteinsin7260healthychinesechildrenandadolescentsmeasuredwithanolympusau5400analyseracrosssectionalstudy AT yushanli agespecificandsexspecificreferenceintervalsfornonfastinglipidsandapolipoproteinsin7260healthychinesechildrenandadolescentsmeasuredwithanolympusau5400analyseracrosssectionalstudy AT quanxianwang agespecificandsexspecificreferenceintervalsfornonfastinglipidsandapolipoproteinsin7260healthychinesechildrenandadolescentsmeasuredwithanolympusau5400analyseracrosssectionalstudy AT linkaiwang agespecificandsexspecificreferenceintervalsfornonfastinglipidsandapolipoproteinsin7260healthychinesechildrenandadolescentsmeasuredwithanolympusau5400analyseracrosssectionalstudy AT yanhuasu agespecificandsexspecificreferenceintervalsfornonfastinglipidsandapolipoproteinsin7260healthychinesechildrenandadolescentsmeasuredwithanolympusau5400analyseracrosssectionalstudy |