Molecular dynamics simulations reveal key roles of the LIF receptor in the assembly of human LIF signaling complex

Molecular dynamics simulations reveal key roles of the LIF receptor in the assembly of human LIF signaling complex

Leukemia inhibitory factor (LIF) is a critical cytokine involved in various biological processes, including stem cell self-renewal, inflammation, and cancer progression. Structural studies have revealed how LIF forms a functional signaling complex. However, the dynamic binding pattern of the complex...

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Bibliographic Details
Main Authors: Bo Gao, Hanrui Liu, Mengkai Zhu, Shun Zhang, Meiniang Wang, Yijun Ruan, Yue Zheng
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Molecular Dynamics
LIF
Gp130
LIFR
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037025000133
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