Protocol for inducing varying TBI severity in a mouse model using a closed-head, weight-drop, impact-induced acceleration mechanism

Protocol for inducing varying TBI severity in a mouse model using a closed-head, weight-drop, impact-induced acceleration mechanism

Summary: Animal models of traumatic brain injury (TBI) are critical for understanding its complex neuropathology. Here, we present a protocol to induce varying TBI severities in mice using a closed-head, weight-drop model that includes an impact-induced acceleration mechanism. We describe steps for...

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Bibliographic Details
Main Authors: Javier Allende Labastida, Massoud Motamedi, Ping Wu, Bartosz Szczesny
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:STAR Protocols
Subjects:
health sciences
model organisms
neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166724005355
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http://www.sciencedirect.com/science/article/pii/S2666166724005355

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