Three-arm polyrotaxanes with multidirectional molecular motions as the nanocarrier for nitric oxide-enhanced photodynamic therapy against bacterial biofilms in septic arthritis

Three-arm polyrotaxanes with multidirectional molecular motions as the nanocarrier for nitric oxide-enhanced photodynamic therapy against bacterial biofilms in septic arthritis

Abstract Bacterial biofilms are one of the major contributors to the refractoriness of septic arthritis. Although nitric oxide (NO)-enhanced photodynamic (PDT) therapy has been involved in biofilm eradication, the anti-biofilm efficacy is usually hindered by the short half-life and limited diffusion...

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Bibliographic Details
Main Authors: Shixin Liu, Yuanfang Jiang, Yu Zhang, Kai Lv, Jiaxin Zhu, Mei Liu, Hao Xu, Genlong Jiao, Wanyong Yang, Guodong Sun, Dong Ma
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Nanobiotechnology
Subjects:
Polyrotaxanes
Multidirectional molecular motions
NO-enhanced PDT
Anti-biofilm therapy
Septic arthritis
Online Access:https://doi.org/10.1186/s12951-024-02953-z
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