Increased plasma interleukin-1β is associated with accelerated lung function decline in non-smokers
Interleukin-1β is one of the major cytokines involved in the initiation and persistence of airway inflammation in chronic obstructive pulmonary disease (COPD). However, the association between plasma interleukin-1β and lung function decline remains unclear. We aimed to explore the association betwee...
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| Format: | Article |
| Language: | English |
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Taylor & Francis
2025-12-01
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| Series: | Pulmonology |
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| Online Access: | http://dx.doi.org/10.1080/25310429.2024.2411811 |
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| author | Xinru Ran Haiqing Li Zihui Wang Fan Wu Zhishan Deng Qiaorui Zhou Cuiqiong Dai Jieqi Peng Lifei Lu Kunning Zhou Pixin Ran Yumin Zhou |
| author_facet | Xinru Ran Haiqing Li Zihui Wang Fan Wu Zhishan Deng Qiaorui Zhou Cuiqiong Dai Jieqi Peng Lifei Lu Kunning Zhou Pixin Ran Yumin Zhou |
| author_sort | Xinru Ran |
| collection | DOAJ |
| description | Interleukin-1β is one of the major cytokines involved in the initiation and persistence of airway inflammation in chronic obstructive pulmonary disease (COPD). However, the association between plasma interleukin-1β and lung function decline remains unclear. We aimed to explore the association between plasma interleukin-1β and lung function decline. This longitudinal evaluation of data from the Early COPD study analysed the association between the plasma interleukin-1β concentration, lung function decline, and COPD exacerbation. Overall, 1,328 participants were included in the baseline analysis, and 1,135 (85%) completed the 1-year follow-up. Increased plasma interleukin-1β was associated with accelerated lung function decline in non-smokers (forced expiratory volume in 1 s: per unit natural log-transformed increase, adjusted unstandardised β [95% confidence interval] 101.46 [16.73–186.18] mL/year, p=0.019; forced vital capacity: per unit natural log-transformed increase, adjusted unstandardised β [95% confidence interval] 146.20 [93.65–198.75] mL/year, p<0.001), but not in smokers. In non-smokers, participants with an interleukin-1β concentration in the top 30% (>5.02 pg/mL) had more respiratory symptoms, more severe emphysema and air trapping, and higher levels of inflammation-related biomarkers. In this study, a subgroup with increased plasma interleukin-1β was identified among non-smokers, and increased plasma interleukin-1β was associated with lung function accelerated decline. |
| format | Article |
| id | doaj-art-0707e6d026e14c30a0beabb94cbeb36e |
| institution | Kabale University |
| issn | 2531-0429 2531-0437 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis |
| record_format | Article |
| series | Pulmonology |
| spelling | doaj-art-0707e6d026e14c30a0beabb94cbeb36e2024-11-15T10:42:42ZengTaylor & FrancisPulmonology2531-04292531-04372025-12-0131110.1080/25310429.2024.24118112411811Increased plasma interleukin-1β is associated with accelerated lung function decline in non-smokersXinru Ran0Haiqing Li1Zihui Wang2Fan Wu3Zhishan Deng4Qiaorui Zhou5Cuiqiong Dai6Jieqi Peng7Lifei Lu8Kunning Zhou9Pixin Ran10Yumin Zhou11Guangzhou Medical UniversityThe First Affiliated Hospital of Guangzhou Medical UniversityThe First Affiliated Hospital of Guangzhou Medical UniversityThe First Affiliated Hospital of Guangzhou Medical UniversityThe First Affiliated Hospital of Guangzhou Medical UniversityThe First Clinical College of Guangzhou Medical UniversityThe First Affiliated Hospital of Guangzhou Medical UniversityThe First Affiliated Hospital of Guangzhou Medical UniversityThe First Affiliated Hospital of Guangzhou Medical UniversityThe First Affiliated Hospital of Guangzhou Medical UniversityThe First Affiliated Hospital of Guangzhou Medical UniversityThe First Affiliated Hospital of Guangzhou Medical UniversityInterleukin-1β is one of the major cytokines involved in the initiation and persistence of airway inflammation in chronic obstructive pulmonary disease (COPD). However, the association between plasma interleukin-1β and lung function decline remains unclear. We aimed to explore the association between plasma interleukin-1β and lung function decline. This longitudinal evaluation of data from the Early COPD study analysed the association between the plasma interleukin-1β concentration, lung function decline, and COPD exacerbation. Overall, 1,328 participants were included in the baseline analysis, and 1,135 (85%) completed the 1-year follow-up. Increased plasma interleukin-1β was associated with accelerated lung function decline in non-smokers (forced expiratory volume in 1 s: per unit natural log-transformed increase, adjusted unstandardised β [95% confidence interval] 101.46 [16.73–186.18] mL/year, p=0.019; forced vital capacity: per unit natural log-transformed increase, adjusted unstandardised β [95% confidence interval] 146.20 [93.65–198.75] mL/year, p<0.001), but not in smokers. In non-smokers, participants with an interleukin-1β concentration in the top 30% (>5.02 pg/mL) had more respiratory symptoms, more severe emphysema and air trapping, and higher levels of inflammation-related biomarkers. In this study, a subgroup with increased plasma interleukin-1β was identified among non-smokers, and increased plasma interleukin-1β was associated with lung function accelerated decline.http://dx.doi.org/10.1080/25310429.2024.2411811interleukin-1βlung function declinechronic obstructive pulmonary diseasecohort study |
| spellingShingle | Xinru Ran Haiqing Li Zihui Wang Fan Wu Zhishan Deng Qiaorui Zhou Cuiqiong Dai Jieqi Peng Lifei Lu Kunning Zhou Pixin Ran Yumin Zhou Increased plasma interleukin-1β is associated with accelerated lung function decline in non-smokers Pulmonology interleukin-1β lung function decline chronic obstructive pulmonary disease cohort study |
| title | Increased plasma interleukin-1β is associated with accelerated lung function decline in non-smokers |
| title_full | Increased plasma interleukin-1β is associated with accelerated lung function decline in non-smokers |
| title_fullStr | Increased plasma interleukin-1β is associated with accelerated lung function decline in non-smokers |
| title_full_unstemmed | Increased plasma interleukin-1β is associated with accelerated lung function decline in non-smokers |
| title_short | Increased plasma interleukin-1β is associated with accelerated lung function decline in non-smokers |
| title_sort | increased plasma interleukin 1β is associated with accelerated lung function decline in non smokers |
| topic | interleukin-1β lung function decline chronic obstructive pulmonary disease cohort study |
| url | http://dx.doi.org/10.1080/25310429.2024.2411811 |
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