Synergistic Effects of Cinnamomum verum and Stingless Bee Honey on Isoproterenol-induced Cardiac Hypertrophic Murine Model
Objective: This study aimed to validate the synergistic effects of Cinnamomum verum (C. verum) barks and stingless bee honey (SBH) against cardiac hypertrophy (CH). Materials and Methods: Isoproterenol (ISO-group II-30 mg/kg)-induced cardiac hypertrophic Wistar rats were used in this study. Hypertro...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | World Journal of Traditional Chinese Medicine |
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| Online Access: | https://journals.lww.com/10.4103/wjtcm.wjtcm_63_24 |
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| author | Arul Mozhi Padmanabhan Victor Arokia Doss |
| author_facet | Arul Mozhi Padmanabhan Victor Arokia Doss |
| author_sort | Arul Mozhi Padmanabhan |
| collection | DOAJ |
| description | Objective:
This study aimed to validate the synergistic effects of Cinnamomum verum (C. verum) barks and stingless bee honey (SBH) against cardiac hypertrophy (CH).
Materials and Methods:
Isoproterenol (ISO-group II-30 mg/kg)-induced cardiac hypertrophic Wistar rats were used in this study. Hypertrophic rats were treated using the reference drug losartan (LOS Group III: 50 mg/kg) and aqueous extracts of C. verum barks and SBH (ACH Group IV: 250 mg/kg and 250 mg/kg). CH was characterized by electrocardiography, hypertrophic indices, and biochemical estimations such as total glucose, protein, albumin, lipid profiles, cardiac marker enzymes, and histopathological studies.
Results:
Rats received ISO had increased levels of glucose, protein, cholesterol, triglycerides, very low-density lipoprotein, and low-density lipoprotein, coupled with decreased levels of albumin and high-density lipoprotein. These levels were restored to near normal when treated with ACH extracts of the standard drugs. Contrary to the ISO-induced myocardial damaged hearts, ACH extracts had a profound effect compared to LOS, which was also reflected in histopathological studies.
Conclusion:
These data explicitly reveal that the ACH have a synergistic cardioprotective (antihypertrophic) effect. |
| format | Article |
| id | doaj-art-06e5ddfb7f6c4df2921be9c93953fe0f |
| institution | Kabale University |
| issn | 2311-8571 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | World Journal of Traditional Chinese Medicine |
| spelling | doaj-art-06e5ddfb7f6c4df2921be9c93953fe0f2025-01-16T08:46:11ZengWolters Kluwer Medknow PublicationsWorld Journal of Traditional Chinese Medicine2311-85712024-12-0110444345010.4103/wjtcm.wjtcm_63_24Synergistic Effects of Cinnamomum verum and Stingless Bee Honey on Isoproterenol-induced Cardiac Hypertrophic Murine ModelArul Mozhi PadmanabhanVictor Arokia DossObjective: This study aimed to validate the synergistic effects of Cinnamomum verum (C. verum) barks and stingless bee honey (SBH) against cardiac hypertrophy (CH). Materials and Methods: Isoproterenol (ISO-group II-30 mg/kg)-induced cardiac hypertrophic Wistar rats were used in this study. Hypertrophic rats were treated using the reference drug losartan (LOS Group III: 50 mg/kg) and aqueous extracts of C. verum barks and SBH (ACH Group IV: 250 mg/kg and 250 mg/kg). CH was characterized by electrocardiography, hypertrophic indices, and biochemical estimations such as total glucose, protein, albumin, lipid profiles, cardiac marker enzymes, and histopathological studies. Results: Rats received ISO had increased levels of glucose, protein, cholesterol, triglycerides, very low-density lipoprotein, and low-density lipoprotein, coupled with decreased levels of albumin and high-density lipoprotein. These levels were restored to near normal when treated with ACH extracts of the standard drugs. Contrary to the ISO-induced myocardial damaged hearts, ACH extracts had a profound effect compared to LOS, which was also reflected in histopathological studies. Conclusion: These data explicitly reveal that the ACH have a synergistic cardioprotective (antihypertrophic) effect.https://journals.lww.com/10.4103/wjtcm.wjtcm_63_24cardiac hypertrophycinnamomum verumisoproterenolmetabolismstingless bee honey |
| spellingShingle | Arul Mozhi Padmanabhan Victor Arokia Doss Synergistic Effects of Cinnamomum verum and Stingless Bee Honey on Isoproterenol-induced Cardiac Hypertrophic Murine Model World Journal of Traditional Chinese Medicine cardiac hypertrophy cinnamomum verum isoproterenol metabolism stingless bee honey |
| title | Synergistic Effects of Cinnamomum verum and Stingless Bee Honey on Isoproterenol-induced Cardiac Hypertrophic Murine Model |
| title_full | Synergistic Effects of Cinnamomum verum and Stingless Bee Honey on Isoproterenol-induced Cardiac Hypertrophic Murine Model |
| title_fullStr | Synergistic Effects of Cinnamomum verum and Stingless Bee Honey on Isoproterenol-induced Cardiac Hypertrophic Murine Model |
| title_full_unstemmed | Synergistic Effects of Cinnamomum verum and Stingless Bee Honey on Isoproterenol-induced Cardiac Hypertrophic Murine Model |
| title_short | Synergistic Effects of Cinnamomum verum and Stingless Bee Honey on Isoproterenol-induced Cardiac Hypertrophic Murine Model |
| title_sort | synergistic effects of cinnamomum verum and stingless bee honey on isoproterenol induced cardiac hypertrophic murine model |
| topic | cardiac hypertrophy cinnamomum verum isoproterenol metabolism stingless bee honey |
| url | https://journals.lww.com/10.4103/wjtcm.wjtcm_63_24 |
| work_keys_str_mv | AT arulmozhipadmanabhan synergisticeffectsofcinnamomumverumandstinglessbeehoneyonisoproterenolinducedcardiachypertrophicmurinemodel AT victorarokiadoss synergisticeffectsofcinnamomumverumandstinglessbeehoneyonisoproterenolinducedcardiachypertrophicmurinemodel |