Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARγ
Mounting evidence suggests that the risk of developing colorectal cancer (CRC) is dramatically increased for patients with chronic inflammatory diseases. For instance, patients with Crohn's Disease (CD) or Ulcerative Colitis (UC) have a 12–20% increased risk for developing CRC. Preventive strat...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2009/498352 |
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| author | Ashlee B. Carter Sarah A. Misyak Raquel Hontecillas Josep Bassaganya-Riera |
| author_facet | Ashlee B. Carter Sarah A. Misyak Raquel Hontecillas Josep Bassaganya-Riera |
| author_sort | Ashlee B. Carter |
| collection | DOAJ |
| description | Mounting evidence suggests that the risk of developing colorectal cancer (CRC) is dramatically increased for patients with chronic inflammatory diseases. For instance, patients with Crohn's Disease (CD) or Ulcerative Colitis (UC) have a 12–20% increased risk for developing CRC. Preventive strategies utilizing nontoxic natural compounds that modulate immune responses could be successful in the suppression of inflammation-driven colorectal cancer in high-risk groups. The increase of peroxisome proliferator-activated receptor-γ (PPAR-γ) expression and its transcriptional activity has been identified as a target for anti-inflammatory efforts, and the suppression of inflammation-driven colon cancer. PPARγ down-modulates inflammation and elicits antiproliferative and proapoptotic actions in epithelial cells. All of which may decrease the risk for inflammation-induced CRC. This review will focus on the use of orally active, naturally occurring chemopreventive approaches against inflammation-induced CRC that target PPARγ and therefore down-modulate inflammation. |
| format | Article |
| id | doaj-art-06dbc1c3da524bd3a77e9a69a1d26dbc |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-06dbc1c3da524bd3a77e9a69a1d26dbc2025-08-20T03:55:24ZengWileyPPAR Research1687-47571687-47652009-01-01200910.1155/2009/498352498352Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARγAshlee B. Carter0Sarah A. Misyak1Raquel Hontecillas2Josep Bassaganya-Riera3Cell and Organism Section, Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USACell and Organism Section, Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USACell and Organism Section, Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USACell and Organism Section, Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USAMounting evidence suggests that the risk of developing colorectal cancer (CRC) is dramatically increased for patients with chronic inflammatory diseases. For instance, patients with Crohn's Disease (CD) or Ulcerative Colitis (UC) have a 12–20% increased risk for developing CRC. Preventive strategies utilizing nontoxic natural compounds that modulate immune responses could be successful in the suppression of inflammation-driven colorectal cancer in high-risk groups. The increase of peroxisome proliferator-activated receptor-γ (PPAR-γ) expression and its transcriptional activity has been identified as a target for anti-inflammatory efforts, and the suppression of inflammation-driven colon cancer. PPARγ down-modulates inflammation and elicits antiproliferative and proapoptotic actions in epithelial cells. All of which may decrease the risk for inflammation-induced CRC. This review will focus on the use of orally active, naturally occurring chemopreventive approaches against inflammation-induced CRC that target PPARγ and therefore down-modulate inflammation.http://dx.doi.org/10.1155/2009/498352 |
| spellingShingle | Ashlee B. Carter Sarah A. Misyak Raquel Hontecillas Josep Bassaganya-Riera Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARγ PPAR Research |
| title | Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARγ |
| title_full | Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARγ |
| title_fullStr | Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARγ |
| title_full_unstemmed | Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARγ |
| title_short | Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARγ |
| title_sort | dietary modulation of inflammation induced colorectal cancer through pparγ |
| url | http://dx.doi.org/10.1155/2009/498352 |
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