Nanostructure‐Mediated Photothermal Effect for Reinforcing Physical Killing Activity of Nanorod Arrays
Abstract The physical killing of bacteria based on surface topography has attracted much attention due to the sustainable and safe prevention of biofilm formation. However, the antibacterial efficiency of biomedical implants derived solely from nanostructures or microstructures is insufficient to co...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202411997 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841543124056276992 |
|---|---|
| author | Guannan Zhang Zehao Li Menlin Sun Ying Lu Jianbo Song Wangping Duan Xiaobo Huang Ruiqiang Hang Xiaohong Yao Paul K Chu Xiangyu Zhang |
| author_facet | Guannan Zhang Zehao Li Menlin Sun Ying Lu Jianbo Song Wangping Duan Xiaobo Huang Ruiqiang Hang Xiaohong Yao Paul K Chu Xiangyu Zhang |
| author_sort | Guannan Zhang |
| collection | DOAJ |
| description | Abstract The physical killing of bacteria based on surface topography has attracted much attention due to the sustainable and safe prevention of biofilm formation. However, the antibacterial efficiency of biomedical implants derived solely from nanostructures or microstructures is insufficient to combat bacteria against common infections, such as methicillin‐resistant Staphylococcus aureus with thick cell walls. Herein, photothermal therapy is carried out in the presence of nanorod arrays to mitigate infection of biomedical implants. Different from traditional photothermal therapy relying on a photosensitizer, the photothermal effect is mediated by light traps rendered by the nanorod arrays, and consequently, the photosensitizer is not needed. Finite element simulations and experiments are performed to elucidate the light‐to‐thermal conversion mechanism. This photothermal platform, in conjunction with thermosensitive nitric oxide therapy, is applied to treat titanium implant infection. The nanostructure‐mediated photothermal effect destroys bacterial cell walls by inhibiting peptidoglycan synthesis and increasing the membrane permeability by affecting fatty acid synthesis. Furthermore, the nanorods synergistically puncture the bacterial membrane easily as demonstrated by experiments and transcriptome analysis. The results provide insights into the development of efficient antibacterial treatment of implants by combining nanostructures and photothermal therapy. |
| format | Article |
| id | doaj-art-06d1de9b2f84435d98f3c33af00e4288 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-06d1de9b2f84435d98f3c33af00e42882025-01-13T15:29:43ZengWileyAdvanced Science2198-38442025-01-01122n/an/a10.1002/advs.202411997Nanostructure‐Mediated Photothermal Effect for Reinforcing Physical Killing Activity of Nanorod ArraysGuannan Zhang0Zehao Li1Menlin Sun2Ying Lu3Jianbo Song4Wangping Duan5Xiaobo Huang6Ruiqiang Hang7Xiaohong Yao8Paul K Chu9Xiangyu Zhang10Shanxi Bethune Hospital Shanxi Academy of Medical Sciences Third Hospital of Shanxi Medical University Tongji Shanxi Hospital Taiyuan 030032 ChinaShanxi Key Laboratory of Biomedical Metal Materials College of Materials Science and Engineering Taiyuan University of Technology Taiyuan 030024 ChinaShanxi Key Laboratory of Biomedical Metal Materials College of Materials Science and Engineering Taiyuan University of Technology Taiyuan 030024 ChinaShanxi Bethune Hospital Shanxi Academy of Medical Sciences Third Hospital of Shanxi Medical University Tongji Shanxi Hospital Taiyuan 030032 ChinaShanxi Bethune Hospital Shanxi Academy of Medical Sciences Third Hospital of Shanxi Medical University Tongji Shanxi Hospital Taiyuan 030032 ChinaShanxi Key Laboratory of Bone and Soft Tissue Injury Repair Department of Orthopedics Second Hospital of Shanxi Medical University Taiyuan 030001 ChinaShanxi Key Laboratory of Biomedical Metal Materials College of Materials Science and Engineering Taiyuan University of Technology Taiyuan 030024 ChinaShanxi Key Laboratory of Biomedical Metal Materials College of Materials Science and Engineering Taiyuan University of Technology Taiyuan 030024 ChinaShanxi Key Laboratory of Biomedical Metal Materials College of Materials Science and Engineering Taiyuan University of Technology Taiyuan 030024 ChinaDepartment of Physics Department of Materials Science and Engineering, and Department of Biomedical Engineering City University of Hong Kong Tat Chee Avenue, Kowloon Hong Kong 999077 ChinaShanxi Key Laboratory of Biomedical Metal Materials College of Materials Science and Engineering Taiyuan University of Technology Taiyuan 030024 ChinaAbstract The physical killing of bacteria based on surface topography has attracted much attention due to the sustainable and safe prevention of biofilm formation. However, the antibacterial efficiency of biomedical implants derived solely from nanostructures or microstructures is insufficient to combat bacteria against common infections, such as methicillin‐resistant Staphylococcus aureus with thick cell walls. Herein, photothermal therapy is carried out in the presence of nanorod arrays to mitigate infection of biomedical implants. Different from traditional photothermal therapy relying on a photosensitizer, the photothermal effect is mediated by light traps rendered by the nanorod arrays, and consequently, the photosensitizer is not needed. Finite element simulations and experiments are performed to elucidate the light‐to‐thermal conversion mechanism. This photothermal platform, in conjunction with thermosensitive nitric oxide therapy, is applied to treat titanium implant infection. The nanostructure‐mediated photothermal effect destroys bacterial cell walls by inhibiting peptidoglycan synthesis and increasing the membrane permeability by affecting fatty acid synthesis. Furthermore, the nanorods synergistically puncture the bacterial membrane easily as demonstrated by experiments and transcriptome analysis. The results provide insights into the development of efficient antibacterial treatment of implants by combining nanostructures and photothermal therapy.https://doi.org/10.1002/advs.202411997anti‐biofilmlight trappingosseointegrationphotothermal therapyphysical puncture |
| spellingShingle | Guannan Zhang Zehao Li Menlin Sun Ying Lu Jianbo Song Wangping Duan Xiaobo Huang Ruiqiang Hang Xiaohong Yao Paul K Chu Xiangyu Zhang Nanostructure‐Mediated Photothermal Effect for Reinforcing Physical Killing Activity of Nanorod Arrays Advanced Science anti‐biofilm light trapping osseointegration photothermal therapy physical puncture |
| title | Nanostructure‐Mediated Photothermal Effect for Reinforcing Physical Killing Activity of Nanorod Arrays |
| title_full | Nanostructure‐Mediated Photothermal Effect for Reinforcing Physical Killing Activity of Nanorod Arrays |
| title_fullStr | Nanostructure‐Mediated Photothermal Effect for Reinforcing Physical Killing Activity of Nanorod Arrays |
| title_full_unstemmed | Nanostructure‐Mediated Photothermal Effect for Reinforcing Physical Killing Activity of Nanorod Arrays |
| title_short | Nanostructure‐Mediated Photothermal Effect for Reinforcing Physical Killing Activity of Nanorod Arrays |
| title_sort | nanostructure mediated photothermal effect for reinforcing physical killing activity of nanorod arrays |
| topic | anti‐biofilm light trapping osseointegration photothermal therapy physical puncture |
| url | https://doi.org/10.1002/advs.202411997 |
| work_keys_str_mv | AT guannanzhang nanostructuremediatedphotothermaleffectforreinforcingphysicalkillingactivityofnanorodarrays AT zehaoli nanostructuremediatedphotothermaleffectforreinforcingphysicalkillingactivityofnanorodarrays AT menlinsun nanostructuremediatedphotothermaleffectforreinforcingphysicalkillingactivityofnanorodarrays AT yinglu nanostructuremediatedphotothermaleffectforreinforcingphysicalkillingactivityofnanorodarrays AT jianbosong nanostructuremediatedphotothermaleffectforreinforcingphysicalkillingactivityofnanorodarrays AT wangpingduan nanostructuremediatedphotothermaleffectforreinforcingphysicalkillingactivityofnanorodarrays AT xiaobohuang nanostructuremediatedphotothermaleffectforreinforcingphysicalkillingactivityofnanorodarrays AT ruiqianghang nanostructuremediatedphotothermaleffectforreinforcingphysicalkillingactivityofnanorodarrays AT xiaohongyao nanostructuremediatedphotothermaleffectforreinforcingphysicalkillingactivityofnanorodarrays AT paulkchu nanostructuremediatedphotothermaleffectforreinforcingphysicalkillingactivityofnanorodarrays AT xiangyuzhang nanostructuremediatedphotothermaleffectforreinforcingphysicalkillingactivityofnanorodarrays |