Sitagliptin eye drops prevent the impairment of retinal neurovascular unit in the new Trpv2 +/− rat model

Sitagliptin eye drops prevent the impairment of retinal neurovascular unit in the new Trpv2 +/− rat model

Abstract Impaired function of the retinal neurovascular unit (NVU) is an early event in diabetic retinopathy (DR). It has been previously shown that topical delivery of the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin can protect against diabetes-mediated dysfunction of the retinal NVU in th...

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Bibliographic Details
Main Authors: Hugo Ramos, Josy Augustine, Burak M. Karan, Cristina Hernández, Alan W. Stitt, Tim M. Curtis, Rafael Simó
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Neuroinflammation
Subjects:
Diabetes
Diabetic retinopathy
Sitagliptin
DPP-4 inhibitor
Trpv2
Online Access:https://doi.org/10.1186/s12974-024-03283-5
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