Kinetic-pharmacodynamic model to predict post-rituximab B-cell repletion as a predictor of relapse in pediatric idiopathic nephrotic syndrome

Kinetic-pharmacodynamic model to predict post-rituximab B-cell repletion as a predictor of relapse in pediatric idiopathic nephrotic syndrome

PurposeRituximab has proven efficacy in children with idiopathic nephrotic syndrome (INS). However, vast majority of children inevitably experience relapse with B-cell repletion, necessitating repeat course of rituximab, which may increase the risk of adverse effects. The timing of additional dosing...

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Bibliographic Details
Main Authors: Ziwei Li, Qian Shen, Hong Xu, Zhiping Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
rituximab
idiopathic nephrotic syndrome
kinetic-pharmacodynamic model
relapse
B-cell
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1526936/full
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