ICAM1 and VCAM1 are associated with outcome in patients with sepsis: A systematic review and meta-analysis
Background: Endothelial cell dysfunction and microcirculatory disturbances play crucial roles in the pathogenesis of sepsis. This systematic review and meta-analysis explored the relationship of the plasma levels of the key endothelial proteins intercellular adhesion molecule 1 (ICAM1) and vascular...
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Elsevier
2024-11-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024160343 |
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| author | Jiawei He Meili Duan Haizhou Zhuang |
| author_facet | Jiawei He Meili Duan Haizhou Zhuang |
| author_sort | Jiawei He |
| collection | DOAJ |
| description | Background: Endothelial cell dysfunction and microcirculatory disturbances play crucial roles in the pathogenesis of sepsis. This systematic review and meta-analysis explored the relationship of the plasma levels of the key endothelial proteins intercellular adhesion molecule 1 (ICAM1) and vascular cell adhesion molecule 1 (VCAM1) with clinical outcomes in patients with sepsis. Methods: MEDLINE and EMBASE were searched through November 28, 2023. ICAM1 and VCAM1 levels and patient outcomes were evaluated. The primary outcome was the relationship of sepsis with ICAM1 or VCAM1. The secondary outcomes were the relationships of septic shock and multiple-organ dysfunction syndrome (MODS) with ICAM1 and VCAM1. Variables were compared using standardized mean differences (SMDs) with 95 % confidence intervals (CIs). Results: Forty-one studies were included. ICAM1 (SMD = 1.12, 95 % CI = 0.67, 1.57; P < 0.00001) and VCAM1 (SMD = 0.65; 95 % CI = 0.17, 1.13; P = 0.008) were associated with sepsis. Similarly, both ICAM1 (SMD = 2.30; 95 % CI = 1.30, 3.31; P < 0.00001) and VCAM1 (SMD = 0.93; 95 % CI = 0.27, 1.59; P = 0.006) were associated with MODS. ICAM1 was associated with septic shock (SMD = 1.93; 95 % CI = 0.55, 3.30; P = 0.006), overall mortality (SMD = −1.18; 95 % CI = −1.76, −0.61; P < 0.0001), and sepsis-related mortality (SMD = −0.64; 95 % CI = −0.88, −0.39; P < 0.00001). VCAM1 was associated with overall mortality (SMD = −0.71; 95 % CI = −1.02, −0.40; P < 0.00001), sepsis-related mortality (SMD = −0.62; 95 % CI = −1.14, −0.10; P = 0.02), and MODS-related mortality (SMD = −0.55; 95 % CI = −0.89, −0.21; P = 0.002). Conclusion: Elevated plasma ICAM1 and VCAM1 levels could increase the risks of sepsis, septic shock, MODS, and mortality. |
| format | Article |
| id | doaj-art-065afbc890a14b13b535f8dfa1059be5 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
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| series | Heliyon |
| spelling | doaj-art-065afbc890a14b13b535f8dfa1059be52024-11-15T06:14:12ZengElsevierHeliyon2405-84402024-11-011021e40003ICAM1 and VCAM1 are associated with outcome in patients with sepsis: A systematic review and meta-analysisJiawei He0Meili Duan1Haizhou Zhuang2Department of Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaCorresponding author.; Department of Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaCorresponding author.; Department of Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaBackground: Endothelial cell dysfunction and microcirculatory disturbances play crucial roles in the pathogenesis of sepsis. This systematic review and meta-analysis explored the relationship of the plasma levels of the key endothelial proteins intercellular adhesion molecule 1 (ICAM1) and vascular cell adhesion molecule 1 (VCAM1) with clinical outcomes in patients with sepsis. Methods: MEDLINE and EMBASE were searched through November 28, 2023. ICAM1 and VCAM1 levels and patient outcomes were evaluated. The primary outcome was the relationship of sepsis with ICAM1 or VCAM1. The secondary outcomes were the relationships of septic shock and multiple-organ dysfunction syndrome (MODS) with ICAM1 and VCAM1. Variables were compared using standardized mean differences (SMDs) with 95 % confidence intervals (CIs). Results: Forty-one studies were included. ICAM1 (SMD = 1.12, 95 % CI = 0.67, 1.57; P < 0.00001) and VCAM1 (SMD = 0.65; 95 % CI = 0.17, 1.13; P = 0.008) were associated with sepsis. Similarly, both ICAM1 (SMD = 2.30; 95 % CI = 1.30, 3.31; P < 0.00001) and VCAM1 (SMD = 0.93; 95 % CI = 0.27, 1.59; P = 0.006) were associated with MODS. ICAM1 was associated with septic shock (SMD = 1.93; 95 % CI = 0.55, 3.30; P = 0.006), overall mortality (SMD = −1.18; 95 % CI = −1.76, −0.61; P < 0.0001), and sepsis-related mortality (SMD = −0.64; 95 % CI = −0.88, −0.39; P < 0.00001). VCAM1 was associated with overall mortality (SMD = −0.71; 95 % CI = −1.02, −0.40; P < 0.00001), sepsis-related mortality (SMD = −0.62; 95 % CI = −1.14, −0.10; P = 0.02), and MODS-related mortality (SMD = −0.55; 95 % CI = −0.89, −0.21; P = 0.002). Conclusion: Elevated plasma ICAM1 and VCAM1 levels could increase the risks of sepsis, septic shock, MODS, and mortality.http://www.sciencedirect.com/science/article/pii/S2405844024160343ICAM1VCAM1SepsisSeptic shockMODSMortality |
| spellingShingle | Jiawei He Meili Duan Haizhou Zhuang ICAM1 and VCAM1 are associated with outcome in patients with sepsis: A systematic review and meta-analysis Heliyon ICAM1 VCAM1 Sepsis Septic shock MODS Mortality |
| title | ICAM1 and VCAM1 are associated with outcome in patients with sepsis: A systematic review and meta-analysis |
| title_full | ICAM1 and VCAM1 are associated with outcome in patients with sepsis: A systematic review and meta-analysis |
| title_fullStr | ICAM1 and VCAM1 are associated with outcome in patients with sepsis: A systematic review and meta-analysis |
| title_full_unstemmed | ICAM1 and VCAM1 are associated with outcome in patients with sepsis: A systematic review and meta-analysis |
| title_short | ICAM1 and VCAM1 are associated with outcome in patients with sepsis: A systematic review and meta-analysis |
| title_sort | icam1 and vcam1 are associated with outcome in patients with sepsis a systematic review and meta analysis |
| topic | ICAM1 VCAM1 Sepsis Septic shock MODS Mortality |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024160343 |
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