Prognostic and clinicopathological significance of pretreatment mean platelet volume in cancer: a meta-analysis
Objective Our study aimed to evaluate the prognostic and clinicopathological significance of pretreatment mean platelet volume (MPV) on cancer by using meta-analysis of published studies.Design Meta-analysis.Data sources Relevant studies available before 22 December 2019 were identified by searching...
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| Format: | Article |
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BMJ Publishing Group
2020-10-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/10/e037614.full |
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| author | Xin Chen Jing Li Xunlei Zhang Yushan Liu Jindong Wu Yangcheng Li Xiaopeng Cui Xiaohui Jiang |
| author_facet | Xin Chen Jing Li Xunlei Zhang Yushan Liu Jindong Wu Yangcheng Li Xiaopeng Cui Xiaohui Jiang |
| author_sort | Xin Chen |
| collection | DOAJ |
| description | Objective Our study aimed to evaluate the prognostic and clinicopathological significance of pretreatment mean platelet volume (MPV) on cancer by using meta-analysis of published studies.Design Meta-analysis.Data sources Relevant studies available before 22 December 2019 were identified by searching MEDLINE, EMBASE.Eligibility criteria All published studies that assessed the prognostic and clinicopathological significance of pretreatment MPV on cancer were included.Data extraction and synthesis Studies were identified and extracted by two reviewers independently. The HR/OR and its 95% CIs of survival outcomes and clinicopathological parameters were calculated.Results A total of 38 eligible studies (41 subsets) with 9894 patients with cancer were included in the final meta-analysis. MPV level was not significantly associated with both overall survival (HR 0.98, 95% CI 0.84 to 1.14) and disease-free survival (HR 1.22, 95% CI 0.86 to 1.73) of patients with cancer. Neither advanced nor mixed-stage tumour patients showed significant association between MPV and overall survival (HR 1.36, 95% CI 0.96 to 1.94, HR 0.90, 95% CI 0.74 to 1.09). However, high MPV had the strongest relationship with poor overall survival (HR 2.01; 95% CI 1.08 to 3.41) in gastric cancer, followed by pancreatic cancer (HR 1.54; 95% CI 1.31 to 1.82). Whereas in the subgroup using receiver operating characteristic curve method to define cut-off values, low MPV was significantly related to poor overall survival (HR 0.78, 95% CI 0.64 to 0.95). In addition, MPV had no significant association with age (OR 0.96, 95% CI 0.90 to 1.02), sex (OR 1.04, 95% CI 1.00 to 1.09), depth of cancer invasion (OR 0.90, 95% CI 0.77 to 1.04) and tumour stage (OR 0.91, 95% CI 0.78 to 1.07).Conclusions Pretreatment MPV level is of no clearly prognostic significance in cancers and no significant association with clinicopathological parameters of patients with cancers. |
| format | Article |
| id | doaj-art-061a18e6adda4fd295fe27bdd04acc04 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-061a18e6adda4fd295fe27bdd04acc042024-11-16T10:40:09ZengBMJ Publishing GroupBMJ Open2044-60552020-10-01101010.1136/bmjopen-2020-037614Prognostic and clinicopathological significance of pretreatment mean platelet volume in cancer: a meta-analysisXin Chen0Jing Li1Xunlei Zhang2Yushan Liu3Jindong Wu4Yangcheng Li5Xiaopeng Cui6Xiaohui Jiang7Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China4 Department of Science and Education, Shenyang Maternity and Child Health Hospital, Shenyang, ChinaDepartment of Oncology, Tumor Hospital Affiliated to Nantong University, Nantong, ChinaDepartment of Pathology, Nantong Tumor Hospital, Nantong, ChinaDepartment of General Surgery, Nantong Tumor Hospital, Nantong, ChinaDepartment of General Surgery, Nantong Tumor Hospital, Nantong, ChinaDepartment of Gastrointestinal Surgery, Nantong University Affiliated Hospital, Nantong, ChinaDepartment of General Surgery, Nantong Tumor Hospital, Nantong, ChinaObjective Our study aimed to evaluate the prognostic and clinicopathological significance of pretreatment mean platelet volume (MPV) on cancer by using meta-analysis of published studies.Design Meta-analysis.Data sources Relevant studies available before 22 December 2019 were identified by searching MEDLINE, EMBASE.Eligibility criteria All published studies that assessed the prognostic and clinicopathological significance of pretreatment MPV on cancer were included.Data extraction and synthesis Studies were identified and extracted by two reviewers independently. The HR/OR and its 95% CIs of survival outcomes and clinicopathological parameters were calculated.Results A total of 38 eligible studies (41 subsets) with 9894 patients with cancer were included in the final meta-analysis. MPV level was not significantly associated with both overall survival (HR 0.98, 95% CI 0.84 to 1.14) and disease-free survival (HR 1.22, 95% CI 0.86 to 1.73) of patients with cancer. Neither advanced nor mixed-stage tumour patients showed significant association between MPV and overall survival (HR 1.36, 95% CI 0.96 to 1.94, HR 0.90, 95% CI 0.74 to 1.09). However, high MPV had the strongest relationship with poor overall survival (HR 2.01; 95% CI 1.08 to 3.41) in gastric cancer, followed by pancreatic cancer (HR 1.54; 95% CI 1.31 to 1.82). Whereas in the subgroup using receiver operating characteristic curve method to define cut-off values, low MPV was significantly related to poor overall survival (HR 0.78, 95% CI 0.64 to 0.95). In addition, MPV had no significant association with age (OR 0.96, 95% CI 0.90 to 1.02), sex (OR 1.04, 95% CI 1.00 to 1.09), depth of cancer invasion (OR 0.90, 95% CI 0.77 to 1.04) and tumour stage (OR 0.91, 95% CI 0.78 to 1.07).Conclusions Pretreatment MPV level is of no clearly prognostic significance in cancers and no significant association with clinicopathological parameters of patients with cancers.https://bmjopen.bmj.com/content/10/10/e037614.full |
| spellingShingle | Xin Chen Jing Li Xunlei Zhang Yushan Liu Jindong Wu Yangcheng Li Xiaopeng Cui Xiaohui Jiang Prognostic and clinicopathological significance of pretreatment mean platelet volume in cancer: a meta-analysis BMJ Open |
| title | Prognostic and clinicopathological significance of pretreatment mean platelet volume in cancer: a meta-analysis |
| title_full | Prognostic and clinicopathological significance of pretreatment mean platelet volume in cancer: a meta-analysis |
| title_fullStr | Prognostic and clinicopathological significance of pretreatment mean platelet volume in cancer: a meta-analysis |
| title_full_unstemmed | Prognostic and clinicopathological significance of pretreatment mean platelet volume in cancer: a meta-analysis |
| title_short | Prognostic and clinicopathological significance of pretreatment mean platelet volume in cancer: a meta-analysis |
| title_sort | prognostic and clinicopathological significance of pretreatment mean platelet volume in cancer a meta analysis |
| url | https://bmjopen.bmj.com/content/10/10/e037614.full |
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