Hyperthermia and biological investigation of a novel magnetic nanobiocomposite based on acacia gum-silk fibroin hydrogel embedded with poly vinyl alcohol
The design and synthesis of biocompatible nanostructures for biomedical applications are considered vital challenges. Herein, a nanobiocomposite based on acacia hydrogel, natural silk fibroin protein, and synthetic protein fibers of polyvinyl alcohol was fabricated and magnetized with iron oxide nan...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-10-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024151043 |
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| author | Zeinab Pajoum Hooman Aghamirza Moghim Aliabadi Adibeh Mohammadi Zahra Sadat Amir Kashtiaray Milad Salimi Bani Mohammadali Shahiri Mohammad Mahdavi Reza Eivazzadeh-Keihan Ali Maleki Majid M. Heravi |
| author_facet | Zeinab Pajoum Hooman Aghamirza Moghim Aliabadi Adibeh Mohammadi Zahra Sadat Amir Kashtiaray Milad Salimi Bani Mohammadali Shahiri Mohammad Mahdavi Reza Eivazzadeh-Keihan Ali Maleki Majid M. Heravi |
| author_sort | Zeinab Pajoum |
| collection | DOAJ |
| description | The design and synthesis of biocompatible nanostructures for biomedical applications are considered vital challenges. Herein, a nanobiocomposite based on acacia hydrogel, natural silk fibroin protein, and synthetic protein fibers of polyvinyl alcohol was fabricated and magnetized with iron oxide nanoparticles (Fe3O4 MNPs). The structural properties of the hybrid nanobiocomposite were investigated by essential analyses such as Fourier Transform Infrared Spectrometer (FTIR), Field emission scanning electron microscopy (FE-SEM), and X-ray powder diffraction)XRD(analyses, Thermogravimetric and Differential thermogravimetric analysis (TGA-DTG), Vibrating-sample magnetometry (VSM), and Energy Dispersive X-Ray Analysis (EDX). The biological activities and functional properties of the prepared magnetic nanobiocomposite were studied. Results proved that this nanobiocomposite is non-toxic to the healthy HEK293T cell line. In addition, the synthesized nanobiocomposite showed an approximately 22 % reduction in cell viability of BT549 cells after 72 h. All results confirmed the anti-cancer properties of nanobiocomposite against breast cancer cell lines. Therefore, the prepared nanobiocomposite is an excellent material that can use for in-vivo application. Finally, the hyperthermia application was evaluated for this nanobiocomposite. The SAR was measured 93.08 (W/g) at 100 kHz. |
| format | Article |
| id | doaj-art-05ff1a8197dd4c5693face06be6e6a57 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-05ff1a8197dd4c5693face06be6e6a572024-11-12T05:19:42ZengElsevierHeliyon2405-84402024-10-011020e39073Hyperthermia and biological investigation of a novel magnetic nanobiocomposite based on acacia gum-silk fibroin hydrogel embedded with poly vinyl alcoholZeinab Pajoum0Hooman Aghamirza Moghim Aliabadi1Adibeh Mohammadi2Zahra Sadat3Amir Kashtiaray4Milad Salimi Bani5Mohammadali Shahiri6Mohammad Mahdavi7Reza Eivazzadeh-Keihan8Ali Maleki9Majid M. Heravi10Department of Chemistry, School of Physics and Chemistry, Alzahra University, PO Box 1993891176, Vanak, Tehran, IranAdvanced Chemical Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, IranCatalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, IranCatalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, IranCatalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, IranDepartment of Optics and Photonics, Wroclaw University of Science and Technology, Wroclaw, PolandDepartment of Biomedical Engineering, Amirkabir University of Technology, Tehran, IranEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IranCatalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran; Corresponding author.Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran; Corresponding author.Department of Chemistry, School of Physics and Chemistry, Alzahra University, PO Box 1993891176, Vanak, Tehran, Iran; Corresponding author.The design and synthesis of biocompatible nanostructures for biomedical applications are considered vital challenges. Herein, a nanobiocomposite based on acacia hydrogel, natural silk fibroin protein, and synthetic protein fibers of polyvinyl alcohol was fabricated and magnetized with iron oxide nanoparticles (Fe3O4 MNPs). The structural properties of the hybrid nanobiocomposite were investigated by essential analyses such as Fourier Transform Infrared Spectrometer (FTIR), Field emission scanning electron microscopy (FE-SEM), and X-ray powder diffraction)XRD(analyses, Thermogravimetric and Differential thermogravimetric analysis (TGA-DTG), Vibrating-sample magnetometry (VSM), and Energy Dispersive X-Ray Analysis (EDX). The biological activities and functional properties of the prepared magnetic nanobiocomposite were studied. Results proved that this nanobiocomposite is non-toxic to the healthy HEK293T cell line. In addition, the synthesized nanobiocomposite showed an approximately 22 % reduction in cell viability of BT549 cells after 72 h. All results confirmed the anti-cancer properties of nanobiocomposite against breast cancer cell lines. Therefore, the prepared nanobiocomposite is an excellent material that can use for in-vivo application. Finally, the hyperthermia application was evaluated for this nanobiocomposite. The SAR was measured 93.08 (W/g) at 100 kHz.http://www.sciencedirect.com/science/article/pii/S2405844024151043Acacia hydrogelSilk fibroinBiological activityHyperthermiaPoly vinyl alcohol |
| spellingShingle | Zeinab Pajoum Hooman Aghamirza Moghim Aliabadi Adibeh Mohammadi Zahra Sadat Amir Kashtiaray Milad Salimi Bani Mohammadali Shahiri Mohammad Mahdavi Reza Eivazzadeh-Keihan Ali Maleki Majid M. Heravi Hyperthermia and biological investigation of a novel magnetic nanobiocomposite based on acacia gum-silk fibroin hydrogel embedded with poly vinyl alcohol Heliyon Acacia hydrogel Silk fibroin Biological activity Hyperthermia Poly vinyl alcohol |
| title | Hyperthermia and biological investigation of a novel magnetic nanobiocomposite based on acacia gum-silk fibroin hydrogel embedded with poly vinyl alcohol |
| title_full | Hyperthermia and biological investigation of a novel magnetic nanobiocomposite based on acacia gum-silk fibroin hydrogel embedded with poly vinyl alcohol |
| title_fullStr | Hyperthermia and biological investigation of a novel magnetic nanobiocomposite based on acacia gum-silk fibroin hydrogel embedded with poly vinyl alcohol |
| title_full_unstemmed | Hyperthermia and biological investigation of a novel magnetic nanobiocomposite based on acacia gum-silk fibroin hydrogel embedded with poly vinyl alcohol |
| title_short | Hyperthermia and biological investigation of a novel magnetic nanobiocomposite based on acacia gum-silk fibroin hydrogel embedded with poly vinyl alcohol |
| title_sort | hyperthermia and biological investigation of a novel magnetic nanobiocomposite based on acacia gum silk fibroin hydrogel embedded with poly vinyl alcohol |
| topic | Acacia hydrogel Silk fibroin Biological activity Hyperthermia Poly vinyl alcohol |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024151043 |
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