A single-snapshot inverse solver for two-species graph model of tau pathology spreading in human Alzheimer’s disease

A single-snapshot inverse solver for two-species graph model of tau pathology spreading in human Alzheimer’s disease

Abstract We propose a method that uses a two-species ordinary differential equation (ODE) model for subject-specific misfolded tau protein spreading in Alzheimer’s disease (AD) and calibrates it from magnetic resonance imaging (MRI) and positron emission tomography (PET) scans. The ODE model is a va...

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Bibliographic Details
Main Authors: Zheyu Wen, Ali Ghafouri, George Biros, the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:Brain Informatics
Subjects:
Alzheimer’s disease
Tau pathology
PET imaging
Biophysical modeling
Inverse problems
Online Access:https://doi.org/10.1186/s40708-025-00264-z
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