Epidermal growth factor and remarkable correlations in a case series COVID-19
Introduction: Molecular links relate epidermal growth factor (EGF) to inflammatory phenomena. In the context of COVID-19, understanding the role of serum concentrations of EGF offered new possibilities for a better understanding of physiopathology and therapeutics. Objective: To explore the behavi...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Spanish |
| Published: |
ECIMED
2024-06-01
|
| Series: | Revista Cubana de Medicina Militar |
| Subjects: | |
| Online Access: | https://revmedmilitar.sld.cu/index.php/mil/article/view/28646 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Introduction: Molecular links relate epidermal growth factor (EGF) to inflammatory phenomena. In the context of COVID-19, understanding the role of serum concentrations of EGF offered new possibilities for a better understanding of physiopathology and therapeutics.
Objective: To explore the behavior of serum EGF values in patients with COVID-19, as well as to determine possible significant correlations between EGF, and analytical and clinical parameters of interest.
Methods: Cross-sectional observational analytical study, in a series of COVID-19 cases that included 15 patients attended between august-september 2021. Variables included: Age, sex, comorbidities, respiratory rate, heart rate, hospital stay, neutrophils, lymphocytes, neutrophil-lymphocyte index. Summary measures: Absolute frequency, percentage, and the arithmetic mean were used. The statistical significance of observable differences between groups was explored with the chi-square test or Welch's t test with a= 0.05.
Results: Notable correlation observed are rEGF-age= -0.6211 (p= 0.0206) overall, with rEGF-age= 0.2998 (p= 0.4030) in critically ill patients and rEGF-age= -0.9607 (p= 0.0000) in patients with care report. In the case of correlation with neutrophils, this is observed in the case of the subset of critical patients (rEGF-PNN= -0.4471, p= 0.3524); in relation to respiratory rate and heart rate, remarkably strong correlations were observed in critically ill patients (rEGF-Rr= 0.8220, p= 0.1928; rEGF-Hr= -0.9285, p= 0.1207).
Conclusions: There is a plausible relationship between serum EGF values and COVID-19, with notably strong correlations for clinical parameters in the context of serious illness. |
|---|---|
| ISSN: | 1561-3046 |