Association between a novel inflammation-lipid composite marker CRP/HDL and erectile dysfunction: evidence from a large national cross-sectional study
BackgroundErectile dysfunction (ED) is one of the most common male sexual disorders, closely associated with both inflammation and lipid dysregulation. Recently, a novel inflammation-lipid composite marker, CRP/HDL, has been proposed to integrate the impact of both pathways on health, yet its relati...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1492836/full |
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| author | Yangyang Mei Yiming Chen Yiming Chen Bo Zhang Bo Zhang Wei Xia Wei Xia Naiyuan Shao Naiyuan Shao Xingliang Feng Xingliang Feng |
| author_facet | Yangyang Mei Yiming Chen Yiming Chen Bo Zhang Bo Zhang Wei Xia Wei Xia Naiyuan Shao Naiyuan Shao Xingliang Feng Xingliang Feng |
| author_sort | Yangyang Mei |
| collection | DOAJ |
| description | BackgroundErectile dysfunction (ED) is one of the most common male sexual disorders, closely associated with both inflammation and lipid dysregulation. Recently, a novel inflammation-lipid composite marker, CRP/HDL, has been proposed to integrate the impact of both pathways on health, yet its relationship with ED remains unexplored. Therefore, our study aimed to investigate the potential association between the CRP/HDL ratio and ED.MethodsWe utilized data from the NHANES database, known for its comprehensive and high-quality information. A total of 3,633 eligible participants from the 2001-2004 cycles were included. ED was assessed using a single-item questionnaire, while CRP and HDL were measured from blood samples. Multivariable regression analyses were performed to evaluate the association between CRP/HDL and ED after adjusting for potential confounders. Additionally, subgroup and sensitivity analyses were conducted to test the robustness of the results, and the linear trend between CRP/HDL and ED was visualized through smooth curve fitting.ResultsAmong the 3,633 participants, 1,027 had a history of ED. The CRP/HDL ratio was significantly higher in participants with ED compared to those without (10.53 ± 0.69 vs. 7.43 ± 0.35, P<0.001). In the regression analysis, a higher continuous CRP/HDL ratio was significantly associated with increased ED risk even after full adjustment (OR: 1.17, 95% CI: 1.05, 1.30; P = 0.01). Compared to Q1 of the CRP/HDL ratio, participants in Q2, Q3, and Q4 had progressively higher ED risks: Q2 (OR: 1.40, 95% CI: 1.01, 1.95; P = 0.05), Q3 (OR: 1.58, 95% CI: 1.10, 2.27; P = 0.02), and Q4 (OR: 1.85, 95% CI: 1.31, 2.60; P = 0.005), showing a clear linear trend. Subgroup analyses indicated consistent results across various populations with no significant interactions, and sensitivity analysis revealed that the CRP/HDL ratio also increased the risk of severe ED (OR: 1.14, 95% CI: 1.03, 1.26; P = 0.02).ConclusionThis is the first study to establish a significant positive association between an elevated CRP/HDL ratio and ED risk, suggesting its potential role in screening for ED risk and guiding timely interventions. However, further large-scale studies are needed to confirm our findings and explore the underlying mechanisms. |
| format | Article |
| id | doaj-art-0571e289174a45d6a14fd76da1ae2510 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-0571e289174a45d6a14fd76da1ae25102024-11-20T04:36:34ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-11-011510.3389/fendo.2024.14928361492836Association between a novel inflammation-lipid composite marker CRP/HDL and erectile dysfunction: evidence from a large national cross-sectional studyYangyang Mei0Yiming Chen1Yiming Chen2Bo Zhang3Bo Zhang4Wei Xia5Wei Xia6Naiyuan Shao7Naiyuan Shao8Xingliang Feng9Xingliang Feng10Department of Urology, Jiangyin People’s Hospital, the Jiangyin Clinical College of Xuzhou Medical University, Jiangyin, Jiangsu, ChinaDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Urology, The First People’s Hospital of Changzhou, Changzhou, Jiangsu, ChinaDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Urology, The First People’s Hospital of Changzhou, Changzhou, Jiangsu, ChinaDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Urology, The First People’s Hospital of Changzhou, Changzhou, Jiangsu, ChinaDepartment of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Neurosurgery, The First People’s Hospital of Changzhou, Changzhou, Jiangsu, ChinaDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Urology, The First People’s Hospital of Changzhou, Changzhou, Jiangsu, ChinaBackgroundErectile dysfunction (ED) is one of the most common male sexual disorders, closely associated with both inflammation and lipid dysregulation. Recently, a novel inflammation-lipid composite marker, CRP/HDL, has been proposed to integrate the impact of both pathways on health, yet its relationship with ED remains unexplored. Therefore, our study aimed to investigate the potential association between the CRP/HDL ratio and ED.MethodsWe utilized data from the NHANES database, known for its comprehensive and high-quality information. A total of 3,633 eligible participants from the 2001-2004 cycles were included. ED was assessed using a single-item questionnaire, while CRP and HDL were measured from blood samples. Multivariable regression analyses were performed to evaluate the association between CRP/HDL and ED after adjusting for potential confounders. Additionally, subgroup and sensitivity analyses were conducted to test the robustness of the results, and the linear trend between CRP/HDL and ED was visualized through smooth curve fitting.ResultsAmong the 3,633 participants, 1,027 had a history of ED. The CRP/HDL ratio was significantly higher in participants with ED compared to those without (10.53 ± 0.69 vs. 7.43 ± 0.35, P<0.001). In the regression analysis, a higher continuous CRP/HDL ratio was significantly associated with increased ED risk even after full adjustment (OR: 1.17, 95% CI: 1.05, 1.30; P = 0.01). Compared to Q1 of the CRP/HDL ratio, participants in Q2, Q3, and Q4 had progressively higher ED risks: Q2 (OR: 1.40, 95% CI: 1.01, 1.95; P = 0.05), Q3 (OR: 1.58, 95% CI: 1.10, 2.27; P = 0.02), and Q4 (OR: 1.85, 95% CI: 1.31, 2.60; P = 0.005), showing a clear linear trend. Subgroup analyses indicated consistent results across various populations with no significant interactions, and sensitivity analysis revealed that the CRP/HDL ratio also increased the risk of severe ED (OR: 1.14, 95% CI: 1.03, 1.26; P = 0.02).ConclusionThis is the first study to establish a significant positive association between an elevated CRP/HDL ratio and ED risk, suggesting its potential role in screening for ED risk and guiding timely interventions. However, further large-scale studies are needed to confirm our findings and explore the underlying mechanisms.https://www.frontiersin.org/articles/10.3389/fendo.2024.1492836/fullNHANESerectile dysfunctioninflammationhigh-density lipoproteincross-sectional study |
| spellingShingle | Yangyang Mei Yiming Chen Yiming Chen Bo Zhang Bo Zhang Wei Xia Wei Xia Naiyuan Shao Naiyuan Shao Xingliang Feng Xingliang Feng Association between a novel inflammation-lipid composite marker CRP/HDL and erectile dysfunction: evidence from a large national cross-sectional study Frontiers in Endocrinology NHANES erectile dysfunction inflammation high-density lipoprotein cross-sectional study |
| title | Association between a novel inflammation-lipid composite marker CRP/HDL and erectile dysfunction: evidence from a large national cross-sectional study |
| title_full | Association between a novel inflammation-lipid composite marker CRP/HDL and erectile dysfunction: evidence from a large national cross-sectional study |
| title_fullStr | Association between a novel inflammation-lipid composite marker CRP/HDL and erectile dysfunction: evidence from a large national cross-sectional study |
| title_full_unstemmed | Association between a novel inflammation-lipid composite marker CRP/HDL and erectile dysfunction: evidence from a large national cross-sectional study |
| title_short | Association between a novel inflammation-lipid composite marker CRP/HDL and erectile dysfunction: evidence from a large national cross-sectional study |
| title_sort | association between a novel inflammation lipid composite marker crp hdl and erectile dysfunction evidence from a large national cross sectional study |
| topic | NHANES erectile dysfunction inflammation high-density lipoprotein cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1492836/full |
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