Sex differences in metabolic dysfunction-associated steatotic liver disease: a narrative review
Understanding the effects of sex and sex differences on liver health and disease is crucial for individualized healthcare and informed decision-making for patients with liver disease. The impact of sex on liver disease varies according to i...
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| Format: | Article |
| Language: | English |
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Ewha Womans University College of Medicine
2024-04-01
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| Series: | The Ewha Medical Journal |
| Subjects: | |
| Online Access: | http://www.e-emj.org/archive/view_article?pid=emj-47-2-17 |
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| _version_ | 1846120557938999296 |
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| author | Sae Kyung Joo Won Kim |
| author_facet | Sae Kyung Joo Won Kim |
| author_sort | Sae Kyung Joo |
| collection | DOAJ |
| description | Understanding the effects of sex and sex differences on liver health and disease
is crucial for individualized healthcare and informed decision-making for
patients with liver disease. The impact of sex on liver disease varies according
to its etiology. Women have a lower prevalence of metabolic
dysfunction-associated steatotic liver disease (MASLD) than men. However,
postmenopausal women face a higher risk of advanced liver fibrosis due to
hormonal influences. Sex differences affect the pathogenesis of MASLD, which
involves a complex process involving several factors such as hormones, obesity,
and the gut microbiome. Furthermore, sex-related differences in the development
of MASLDrelated hepatocellular carcinoma have been observed. The sex-specific
characteristics of MASLD necessitate an individualized management approach based
on scientific evidence. However, research in this area has been lacking. This
article reviews the current understanding of sex differences in MASLD. |
| format | Article |
| id | doaj-art-054c53fa0f6d4a6db0c97ea1642fe0a6 |
| institution | Kabale University |
| issn | 2234-2591 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Ewha Womans University College of Medicine |
| record_format | Article |
| series | The Ewha Medical Journal |
| spelling | doaj-art-054c53fa0f6d4a6db0c97ea1642fe0a62024-12-16T08:43:16ZengEwha Womans University College of MedicineThe Ewha Medical Journal2234-25912024-04-0147210.12771/emj.2024.e17emj-47-2-17Sex differences in metabolic dysfunction-associated steatotic liver disease: a narrative reviewSae Kyung JooWon KimUnderstanding the effects of sex and sex differences on liver health and disease is crucial for individualized healthcare and informed decision-making for patients with liver disease. The impact of sex on liver disease varies according to its etiology. Women have a lower prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) than men. However, postmenopausal women face a higher risk of advanced liver fibrosis due to hormonal influences. Sex differences affect the pathogenesis of MASLD, which involves a complex process involving several factors such as hormones, obesity, and the gut microbiome. Furthermore, sex-related differences in the development of MASLDrelated hepatocellular carcinoma have been observed. The sex-specific characteristics of MASLD necessitate an individualized management approach based on scientific evidence. However, research in this area has been lacking. This article reviews the current understanding of sex differences in MASLD.http://www.e-emj.org/archive/view_article?pid=emj-47-2-17gastrointestinal microbiomehepatocellular carcinomaliver cirrhosispostmenopausesex characteristics |
| spellingShingle | Sae Kyung Joo Won Kim Sex differences in metabolic dysfunction-associated steatotic liver disease: a narrative review The Ewha Medical Journal gastrointestinal microbiome hepatocellular carcinoma liver cirrhosis postmenopause sex characteristics |
| title | Sex differences in metabolic dysfunction-associated steatotic liver
disease: a narrative review |
| title_full | Sex differences in metabolic dysfunction-associated steatotic liver
disease: a narrative review |
| title_fullStr | Sex differences in metabolic dysfunction-associated steatotic liver
disease: a narrative review |
| title_full_unstemmed | Sex differences in metabolic dysfunction-associated steatotic liver
disease: a narrative review |
| title_short | Sex differences in metabolic dysfunction-associated steatotic liver
disease: a narrative review |
| title_sort | sex differences in metabolic dysfunction associated steatotic liver disease a narrative review |
| topic | gastrointestinal microbiome hepatocellular carcinoma liver cirrhosis postmenopause sex characteristics |
| url | http://www.e-emj.org/archive/view_article?pid=emj-47-2-17 |
| work_keys_str_mv | AT saekyungjoo sexdifferencesinmetabolicdysfunctionassociatedsteatoticliverdiseaseanarrativereview AT wonkim sexdifferencesinmetabolicdysfunctionassociatedsteatoticliverdiseaseanarrativereview |