Deciphering genomic complexity: Understanding intratumor heterogeneity, clonal evolution, and therapeutic vulnerabilities in oral squamous cell carcinoma

Deciphering genomic complexity: Understanding intratumor heterogeneity, clonal evolution, and therapeutic vulnerabilities in oral squamous cell carcinoma

Oral squamous cell carcinoma (OSCC), which is characterized by high rates of recurrence and metastasis, is a prevalent and burdensome form of head and neck cancer. Genomic heterogeneity and clonal evolution play critical roles in OSCC progression and therapeutic resistance. This review comprehensive...

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Bibliographic Details
Main Authors: Vishnu Priya Veeraraghavan, Bharati R. Doni, Arun Kumar Dasari, Chaitra Patil, Krishna A. Rao, Santosh R. Patil
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Oral Oncology Reports
Subjects:
Oral squamous cell carcinoma
Genomic heterogeneity
Intratumor heterogeneity
Clonal evolution
Driver mutations
Targeted therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2772906024003157
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