Deciphering genomic complexity: Understanding intratumor heterogeneity, clonal evolution, and therapeutic vulnerabilities in oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC), which is characterized by high rates of recurrence and metastasis, is a prevalent and burdensome form of head and neck cancer. Genomic heterogeneity and clonal evolution play critical roles in OSCC progression and therapeutic resistance. This review comprehensive...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-06-01
|
| Series: | Oral Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024003157 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841553646544748544 |
|---|---|
| author | Vishnu Priya Veeraraghavan Bharati R. Doni Arun Kumar Dasari Chaitra Patil Krishna A. Rao Santosh R. Patil |
| author_facet | Vishnu Priya Veeraraghavan Bharati R. Doni Arun Kumar Dasari Chaitra Patil Krishna A. Rao Santosh R. Patil |
| author_sort | Vishnu Priya Veeraraghavan |
| collection | DOAJ |
| description | Oral squamous cell carcinoma (OSCC), which is characterized by high rates of recurrence and metastasis, is a prevalent and burdensome form of head and neck cancer. Genomic heterogeneity and clonal evolution play critical roles in OSCC progression and therapeutic resistance. This review comprehensively examines the current understanding of genomic heterogeneity in OSCC, focusing on intratumoral heterogeneity and clonal evolution. Key driver mutations and therapeutic vulnerabilities were identified using next-generation sequencing and functional genomics approaches. The clinical implications include personalized treatment approaches, prognostic biomarkers, and targeted therapy selection. Challenges, such as intratumor heterogeneity and acquired resistance, are discussed, along with future directions for therapeutic strategies. The integration of genomic profiling into clinical practice enhances risk assessment, treatment outcomes, and patient care in OSCC management. |
| format | Article |
| id | doaj-art-0539489b4925477bbaba19f50f0c5bf4 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-0539489b4925477bbaba19f50f0c5bf42025-01-09T06:16:25ZengElsevierOral Oncology Reports2772-90602024-06-0110100469Deciphering genomic complexity: Understanding intratumor heterogeneity, clonal evolution, and therapeutic vulnerabilities in oral squamous cell carcinomaVishnu Priya Veeraraghavan0Bharati R. Doni1Arun Kumar Dasari2Chaitra Patil3Krishna A. Rao4Santosh R. Patil5Centre of Molecular Medicine and Diagnostics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, TamilNadu, IndiaDepartment of Dentistry, Koppal Institute of Medical Sciences, Karnataka, IndiaDepartment of Orthodontics, SVS Institute of Dental Sciences, Mahabubnagar, Telangana, IndiaDepartment of Oral & Maxillofacial Surgery, Krishnadevaraya College of Dental Sciences & Hospital, Bangalore, IndiaDepartment of Preventive Dentistry, College of Dentistry, Jouf University, Saudi ArabiaDepartment of Oral Medicine and Radiology, Chhattisgarh Dental College and Research Institute, India; Corresponding author. Department of Oral Medicine and Radiology, Chhattisgarh Dental College and Research Institute, Chhattisgarh, 491441, India.Oral squamous cell carcinoma (OSCC), which is characterized by high rates of recurrence and metastasis, is a prevalent and burdensome form of head and neck cancer. Genomic heterogeneity and clonal evolution play critical roles in OSCC progression and therapeutic resistance. This review comprehensively examines the current understanding of genomic heterogeneity in OSCC, focusing on intratumoral heterogeneity and clonal evolution. Key driver mutations and therapeutic vulnerabilities were identified using next-generation sequencing and functional genomics approaches. The clinical implications include personalized treatment approaches, prognostic biomarkers, and targeted therapy selection. Challenges, such as intratumor heterogeneity and acquired resistance, are discussed, along with future directions for therapeutic strategies. The integration of genomic profiling into clinical practice enhances risk assessment, treatment outcomes, and patient care in OSCC management.http://www.sciencedirect.com/science/article/pii/S2772906024003157Oral squamous cell carcinomaGenomic heterogeneityIntratumor heterogeneityClonal evolutionDriver mutationsTargeted therapy |
| spellingShingle | Vishnu Priya Veeraraghavan Bharati R. Doni Arun Kumar Dasari Chaitra Patil Krishna A. Rao Santosh R. Patil Deciphering genomic complexity: Understanding intratumor heterogeneity, clonal evolution, and therapeutic vulnerabilities in oral squamous cell carcinoma Oral Oncology Reports Oral squamous cell carcinoma Genomic heterogeneity Intratumor heterogeneity Clonal evolution Driver mutations Targeted therapy |
| title | Deciphering genomic complexity: Understanding intratumor heterogeneity, clonal evolution, and therapeutic vulnerabilities in oral squamous cell carcinoma |
| title_full | Deciphering genomic complexity: Understanding intratumor heterogeneity, clonal evolution, and therapeutic vulnerabilities in oral squamous cell carcinoma |
| title_fullStr | Deciphering genomic complexity: Understanding intratumor heterogeneity, clonal evolution, and therapeutic vulnerabilities in oral squamous cell carcinoma |
| title_full_unstemmed | Deciphering genomic complexity: Understanding intratumor heterogeneity, clonal evolution, and therapeutic vulnerabilities in oral squamous cell carcinoma |
| title_short | Deciphering genomic complexity: Understanding intratumor heterogeneity, clonal evolution, and therapeutic vulnerabilities in oral squamous cell carcinoma |
| title_sort | deciphering genomic complexity understanding intratumor heterogeneity clonal evolution and therapeutic vulnerabilities in oral squamous cell carcinoma |
| topic | Oral squamous cell carcinoma Genomic heterogeneity Intratumor heterogeneity Clonal evolution Driver mutations Targeted therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024003157 |
| work_keys_str_mv | AT vishnupriyaveeraraghavan decipheringgenomiccomplexityunderstandingintratumorheterogeneityclonalevolutionandtherapeuticvulnerabilitiesinoralsquamouscellcarcinoma AT bharatirdoni decipheringgenomiccomplexityunderstandingintratumorheterogeneityclonalevolutionandtherapeuticvulnerabilitiesinoralsquamouscellcarcinoma AT arunkumardasari decipheringgenomiccomplexityunderstandingintratumorheterogeneityclonalevolutionandtherapeuticvulnerabilitiesinoralsquamouscellcarcinoma AT chaitrapatil decipheringgenomiccomplexityunderstandingintratumorheterogeneityclonalevolutionandtherapeuticvulnerabilitiesinoralsquamouscellcarcinoma AT krishnaarao decipheringgenomiccomplexityunderstandingintratumorheterogeneityclonalevolutionandtherapeuticvulnerabilitiesinoralsquamouscellcarcinoma AT santoshrpatil decipheringgenomiccomplexityunderstandingintratumorheterogeneityclonalevolutionandtherapeuticvulnerabilitiesinoralsquamouscellcarcinoma |