Effect of mRNA formulated with lipid nanoparticles on the transcriptomic and epigenetic profiles of F4/80+ liver-associated macrophages

Effect of mRNA formulated with lipid nanoparticles on the transcriptomic and epigenetic profiles of F4/80+ liver-associated macrophages

Abstract Delivery of an mRNA formulated with lipid nanoparticles (LNPs) induces robust humoral and cell-mediated branches of the immune response. Depending on the LNP formula, mRNA encoding proteins can be detected in the liver upon intramuscular administration of mRNA/LNP in mice. This study invest...

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Bibliographic Details
Main Authors: Chitsuda Pongma, Pornlapat Keawvilai, Atsadang Boonmee, Benjawan Wongprom, Thitiporn Pattarakankul, Chutamath Sittplangkoon, Mohamad-Gabriel Alameh, Patipark Kueanjinda, James Heyes, Kieu Lam, Benjawan Saechue, Kiat Ruxrungtham, Tanapat Palaga
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
mRNA
Immunization
Macrophage
Liver
Epigenetics
Online Access:https://doi.org/10.1038/s41598-025-85234-5
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