Signature of pre-pregnancy microbiome in infertile women undergoing frozen embryo transfer with gestational diabetes mellitus
Abstract This study aims to evaluate differences in gut microbiota structures between infertile women undergoing frozen embryo transfer (FET) with gestational diabetes mellitus (GDM) and healthy controls (HCs), and to identify potential markers. We comprehensively enrolled 193 infertile women underg...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-024-00639-w |
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| _version_ | 1841544917190443008 |
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| author | Wenzheng Guan Tian Zhou Jiao Jiao Liwen Xiao Zhen Wang Siyuan Liu Fujie Yan Fangqing Zhao Xiuxia Wang |
| author_facet | Wenzheng Guan Tian Zhou Jiao Jiao Liwen Xiao Zhen Wang Siyuan Liu Fujie Yan Fangqing Zhao Xiuxia Wang |
| author_sort | Wenzheng Guan |
| collection | DOAJ |
| description | Abstract This study aims to evaluate differences in gut microbiota structures between infertile women undergoing frozen embryo transfer (FET) with gestational diabetes mellitus (GDM) and healthy controls (HCs), and to identify potential markers. We comprehensively enrolled 193 infertile women undergoing FET (discovery cohort: 38 HCs and 31 GDM; validation cohort: 85 HCs and 39 GDM). Gut microbial profiles of the discovery cohort were investigated during the pre-pregnancy (Pre), first trimester (T1), and second trimester (T2). The microbial community in the HCs group remained relatively stable throughout the pregnancy, while the microbial structure alteration occurred in the GDM group during T2. A model based on ten bacteria and ten metabolites simultaneously was used to predict the risk of GDM developing in the pre-pregnancy state with the ROC value of 0.712. Algorithms on the basis of marker species and biochemical parameters can be used as effective tools for GDM risk evaluation before pregnancy. |
| format | Article |
| id | doaj-art-0511c9ec2a3c4d119633cc80058d24c0 |
| institution | Kabale University |
| issn | 2055-5008 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj-art-0511c9ec2a3c4d119633cc80058d24c02025-01-12T12:10:04ZengNature Portfolionpj Biofilms and Microbiomes2055-50082025-01-0111111110.1038/s41522-024-00639-wSignature of pre-pregnancy microbiome in infertile women undergoing frozen embryo transfer with gestational diabetes mellitusWenzheng Guan0Tian Zhou1Jiao Jiao2Liwen Xiao3Zhen Wang4Siyuan Liu5Fujie Yan6Fangqing Zhao7Xiuxia Wang8Center of Reproductive Medicine, Shengjing Hospital of China Medical UniversityUniversity of Chinese Academy of SciencesCenter of Reproductive Medicine, Shengjing Hospital of China Medical UniversityInstitute of Zoology, Chinese Academy of SciencesShenyang Reproductive Health Clinical Medicine Research CenterCenter of Reproductive Medicine, Shengjing Hospital of China Medical UniversityDepartment of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang UniversityUniversity of Chinese Academy of SciencesCenter of Reproductive Medicine, Shengjing Hospital of China Medical UniversityAbstract This study aims to evaluate differences in gut microbiota structures between infertile women undergoing frozen embryo transfer (FET) with gestational diabetes mellitus (GDM) and healthy controls (HCs), and to identify potential markers. We comprehensively enrolled 193 infertile women undergoing FET (discovery cohort: 38 HCs and 31 GDM; validation cohort: 85 HCs and 39 GDM). Gut microbial profiles of the discovery cohort were investigated during the pre-pregnancy (Pre), first trimester (T1), and second trimester (T2). The microbial community in the HCs group remained relatively stable throughout the pregnancy, while the microbial structure alteration occurred in the GDM group during T2. A model based on ten bacteria and ten metabolites simultaneously was used to predict the risk of GDM developing in the pre-pregnancy state with the ROC value of 0.712. Algorithms on the basis of marker species and biochemical parameters can be used as effective tools for GDM risk evaluation before pregnancy.https://doi.org/10.1038/s41522-024-00639-w |
| spellingShingle | Wenzheng Guan Tian Zhou Jiao Jiao Liwen Xiao Zhen Wang Siyuan Liu Fujie Yan Fangqing Zhao Xiuxia Wang Signature of pre-pregnancy microbiome in infertile women undergoing frozen embryo transfer with gestational diabetes mellitus npj Biofilms and Microbiomes |
| title | Signature of pre-pregnancy microbiome in infertile women undergoing frozen embryo transfer with gestational diabetes mellitus |
| title_full | Signature of pre-pregnancy microbiome in infertile women undergoing frozen embryo transfer with gestational diabetes mellitus |
| title_fullStr | Signature of pre-pregnancy microbiome in infertile women undergoing frozen embryo transfer with gestational diabetes mellitus |
| title_full_unstemmed | Signature of pre-pregnancy microbiome in infertile women undergoing frozen embryo transfer with gestational diabetes mellitus |
| title_short | Signature of pre-pregnancy microbiome in infertile women undergoing frozen embryo transfer with gestational diabetes mellitus |
| title_sort | signature of pre pregnancy microbiome in infertile women undergoing frozen embryo transfer with gestational diabetes mellitus |
| url | https://doi.org/10.1038/s41522-024-00639-w |
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