Salidroside enhances 5-fluorouracil sensitivity against hepatocellular carcinoma via YIPF5-induced mitophagy

Salidroside enhances 5-fluorouracil sensitivity against hepatocellular carcinoma via YIPF5-induced mitophagy

Hepatocellular carcinoma (HCC) is a major medical challenge due to its high incidence and poor prognosis. 5-Fluorouracil (5-FU), although extensively studied in the treatment of HCC and other solid tumors, has limited application as a first-line therapy for HCC due to its resistance and significant...

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Bibliographic Details
Main Authors: Sumin Sun, Haili Hu, Feiyu Li, Sheng Huan, Long Chen, Jiahui Chen, Peihua Sun, Xiaoqing Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
salidroside
5-fluorouracil
mitophagy
senescence
mitosis
hepatocellular carcinoma
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1503490/full
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