Current advances in multimodal imaging in geographic atrophy secondary to age-related macular degeneration: A review
As we move toward an era in which there will be treatment options for geographic atrophy (GA) secondary to age-related macular degeneration, the need to accurately understand and interpret multimodal imaging (MMI) for the condition is paramount. This review discusses the evolution of MMI in GA and h...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Taiwan Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/tjo.TJO-D-24-00065 |
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| author | Amy C. Cohn Robyn H. Guymer |
| author_facet | Amy C. Cohn Robyn H. Guymer |
| author_sort | Amy C. Cohn |
| collection | DOAJ |
| description | As we move toward an era in which there will be treatment options for geographic atrophy (GA) secondary to age-related macular degeneration, the need to accurately understand and interpret multimodal imaging (MMI) for the condition is paramount. This review discusses the evolution of MMI in GA and how it has led to a greater understanding of different phenotypes and risk factors for progression. These advancements have allowed novel imaging biomarkers to be used as end points in large interventional studies exploring new therapies for GA treatment. Due to differences in drug approval timing, ophthalmologists in some jurisdictions are already treating patients with complement inhibiting intravitreal therapies and using MMI to guide management. Cementing knowledge of how GA appears on MMI and evolves over time will be vital for best practice as these interventions become more widely available. |
| format | Article |
| id | doaj-art-04f7db11ca374adb965db99277316c93 |
| institution | Kabale University |
| issn | 2211-5056 2211-5072 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Taiwan Journal of Ophthalmology |
| spelling | doaj-art-04f7db11ca374adb965db99277316c932025-01-14T15:49:55ZengWolters Kluwer Medknow PublicationsTaiwan Journal of Ophthalmology2211-50562211-50722024-12-0114446447210.4103/tjo.TJO-D-24-00065Current advances in multimodal imaging in geographic atrophy secondary to age-related macular degeneration: A reviewAmy C. CohnRobyn H. GuymerAs we move toward an era in which there will be treatment options for geographic atrophy (GA) secondary to age-related macular degeneration, the need to accurately understand and interpret multimodal imaging (MMI) for the condition is paramount. This review discusses the evolution of MMI in GA and how it has led to a greater understanding of different phenotypes and risk factors for progression. These advancements have allowed novel imaging biomarkers to be used as end points in large interventional studies exploring new therapies for GA treatment. Due to differences in drug approval timing, ophthalmologists in some jurisdictions are already treating patients with complement inhibiting intravitreal therapies and using MMI to guide management. Cementing knowledge of how GA appears on MMI and evolves over time will be vital for best practice as these interventions become more widely available.https://journals.lww.com/10.4103/tjo.TJO-D-24-00065geographic atrophyage-related macular degenerationcomplement inhibitionimagingauto-fluorescence |
| spellingShingle | Amy C. Cohn Robyn H. Guymer Current advances in multimodal imaging in geographic atrophy secondary to age-related macular degeneration: A review Taiwan Journal of Ophthalmology geographic atrophy age-related macular degeneration complement inhibition imaging auto-fluorescence |
| title | Current advances in multimodal imaging in geographic atrophy secondary to age-related macular degeneration: A review |
| title_full | Current advances in multimodal imaging in geographic atrophy secondary to age-related macular degeneration: A review |
| title_fullStr | Current advances in multimodal imaging in geographic atrophy secondary to age-related macular degeneration: A review |
| title_full_unstemmed | Current advances in multimodal imaging in geographic atrophy secondary to age-related macular degeneration: A review |
| title_short | Current advances in multimodal imaging in geographic atrophy secondary to age-related macular degeneration: A review |
| title_sort | current advances in multimodal imaging in geographic atrophy secondary to age related macular degeneration a review |
| topic | geographic atrophy age-related macular degeneration complement inhibition imaging auto-fluorescence |
| url | https://journals.lww.com/10.4103/tjo.TJO-D-24-00065 |
| work_keys_str_mv | AT amyccohn currentadvancesinmultimodalimagingingeographicatrophysecondarytoagerelatedmaculardegenerationareview AT robynhguymer currentadvancesinmultimodalimagingingeographicatrophysecondarytoagerelatedmaculardegenerationareview |