Ataxin-2: a powerful RNA-binding protein
Abstract Ataxin-2 (ATXN2) was originally discovered in the context of spinocerebellar ataxia type 2 (SCA2), but it has become a key player in various neurodegenerative diseases. This review delves into the multifaceted roles of ATXN2 in human diseases, revealing its diverse molecular and cellular pa...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2024-07-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-024-01158-y |
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| _version_ | 1841559333572182016 |
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| author | Lulu Li Meng Wang Lai Huang Xiaoli Zheng Lina Wang Hongming Miao |
| author_facet | Lulu Li Meng Wang Lai Huang Xiaoli Zheng Lina Wang Hongming Miao |
| author_sort | Lulu Li |
| collection | DOAJ |
| description | Abstract Ataxin-2 (ATXN2) was originally discovered in the context of spinocerebellar ataxia type 2 (SCA2), but it has become a key player in various neurodegenerative diseases. This review delves into the multifaceted roles of ATXN2 in human diseases, revealing its diverse molecular and cellular pathways. The impact of ATXN2 on diseases extends beyond functional outcomes; it mainly interacts with various RNA-binding proteins (RBPs) to regulate different stages of post-transcriptional gene expression in diseases. With the progress of research, ATXN2 has also been found to play an important role in the development of various cancers, including breast cancer, gastric cancer, pancreatic cancer, colon cancer, and esophageal cancer. This comprehensive exploration underscores the crucial role of ATXN2 in the pathogenesis of diseases and warrants further investigation by the scientific community. By reviewing the latest discoveries on the regulatory functions of ATXN2 in diseases, this article helps us understand the complex molecular mechanisms of a series of human diseases related to this intriguing protein. |
| format | Article |
| id | doaj-art-04dde4f1a8a54bdc8a7034d975b0440c |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-04dde4f1a8a54bdc8a7034d975b0440c2025-01-05T12:34:21ZengSpringerDiscover Oncology2730-60112024-07-0115112010.1007/s12672-024-01158-yAtaxin-2: a powerful RNA-binding proteinLulu Li0Meng Wang1Lai Huang2Xiaoli Zheng3Lina Wang4Hongming Miao5School of Basic Medical Science, Southwest Medical UniversityDepartment of Pathophysiology, College of High Altitude Military Medicine, Army Medical UniversityDepartment of Clinical and Military Laboratory Medicine, College of Medical Laboratory Science, Army Medical UniversitySchool of Basic Medical Science, Southwest Medical UniversityDepartment of Clinical and Military Laboratory Medicine, College of Medical Laboratory Science, Army Medical UniversityDepartment of Pathophysiology, College of High Altitude Military Medicine, Army Medical UniversityAbstract Ataxin-2 (ATXN2) was originally discovered in the context of spinocerebellar ataxia type 2 (SCA2), but it has become a key player in various neurodegenerative diseases. This review delves into the multifaceted roles of ATXN2 in human diseases, revealing its diverse molecular and cellular pathways. The impact of ATXN2 on diseases extends beyond functional outcomes; it mainly interacts with various RNA-binding proteins (RBPs) to regulate different stages of post-transcriptional gene expression in diseases. With the progress of research, ATXN2 has also been found to play an important role in the development of various cancers, including breast cancer, gastric cancer, pancreatic cancer, colon cancer, and esophageal cancer. This comprehensive exploration underscores the crucial role of ATXN2 in the pathogenesis of diseases and warrants further investigation by the scientific community. By reviewing the latest discoveries on the regulatory functions of ATXN2 in diseases, this article helps us understand the complex molecular mechanisms of a series of human diseases related to this intriguing protein.https://doi.org/10.1007/s12672-024-01158-yATXN2Metabolism of RNARNA binding proteinNeurodegenerative diseasesCancers |
| spellingShingle | Lulu Li Meng Wang Lai Huang Xiaoli Zheng Lina Wang Hongming Miao Ataxin-2: a powerful RNA-binding protein Discover Oncology ATXN2 Metabolism of RNA RNA binding protein Neurodegenerative diseases Cancers |
| title | Ataxin-2: a powerful RNA-binding protein |
| title_full | Ataxin-2: a powerful RNA-binding protein |
| title_fullStr | Ataxin-2: a powerful RNA-binding protein |
| title_full_unstemmed | Ataxin-2: a powerful RNA-binding protein |
| title_short | Ataxin-2: a powerful RNA-binding protein |
| title_sort | ataxin 2 a powerful rna binding protein |
| topic | ATXN2 Metabolism of RNA RNA binding protein Neurodegenerative diseases Cancers |
| url | https://doi.org/10.1007/s12672-024-01158-y |
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