Immune Cell-Based versus Albumin-Based Ratios as Outcome Predictors in Critically Ill COVID-19 Patients
Snjezana Zeba,1 Maja Surbatovic,2 Ivo Udovicic,1 Ivan Stanojevic,3 Danilo Vojvodic,3 Goran Rondovic,1 Katarina Mladenovic,1 Tanja Abazovic,2 Almina Hasanovic,4 Aleksandra N Ilic,5 Dzihan Abazovic,6 Wasim Khan,7 Dragan Djordjevic1 1Clinic of Anesthesiology and Intensive Therapy, Military Medical Acad...
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Dove Medical Press
2025-01-01
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| Series: | Journal of Inflammation Research |
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| author | Zeba S Surbatovic M Udovicic I Stanojevic I Vojvodic D Rondovic G Mladenovic K Abazovic T Hasanovic A Ilic AN Abazovic D Khan W Djordjevic D |
| author_facet | Zeba S Surbatovic M Udovicic I Stanojevic I Vojvodic D Rondovic G Mladenovic K Abazovic T Hasanovic A Ilic AN Abazovic D Khan W Djordjevic D |
| author_sort | Zeba S |
| collection | DOAJ |
| description | Snjezana Zeba,1 Maja Surbatovic,2 Ivo Udovicic,1 Ivan Stanojevic,3 Danilo Vojvodic,3 Goran Rondovic,1 Katarina Mladenovic,1 Tanja Abazovic,2 Almina Hasanovic,4 Aleksandra N Ilic,5 Dzihan Abazovic,6 Wasim Khan,7 Dragan Djordjevic1 1Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy, Faculty of Medicine of the Military Medical Academy, University of Defense, Belgrade, Serbia; 2Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy, Belgrade, Serbia; 3Institute for Medical Research, Military Medical Academy, Faculty of Medicine of the Military Medical Academy, University of Defense, Belgrade, Serbia; 4Nephrology Clinic, Military Medical Academy, Belgrade, Serbia; 5Faculty of Medicine, University of Pristina, Kosovska Mitrovica, Serbia; 6Atlas Hospital, Belgrade, Serbia, Aba Medica Healthcare Centre, Ulcinj, Montenegro; 7Division of Trauma & Orthopaedic Surgery, University of Cambridge, Addenbrooke’s Hospital, Cambridge, CB2 2QQ, UKCorrespondence: Maja Surbatovic, Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy, 17 Crnotravska Street, Belgrade, 11000, Serbia, Tel +381 11 2665 125, Email maja.surbatovic@gmail.comPurpose: The aim of the retrospective, single-center study was to assess the prognostic value of immune cell-based and albumin-based ratios regarding lethal outcome in critically ill COVID-19 patients.Patients and Methods: We analyzed 612 adult critically ill COVID-19 patients admitted to the intensive care unit (ICU) between April 2020 and November 2022. Blood measurement on admission to the ICU encompassed complete blood count (CBC), IL-6, C-reactive protein (CRP), albumin, lactate, lactate dehydrogenase (LDH), serum bicarbonate, arterial base deficit/excess (BD/E), and D-dimer. All the measured and calculated parameters were compared between survivors and nonsurvivors, with the outcome measure being hospital mortality.Results: Immune cell-based ratios [NLR - Neutrophil-to-Lymphocyte Ratio, MLR - Monocyte-to-Lymphocyte Ratio, PLR - Platelet-to-Lymphocyte Ratio, MPV - Mean Platelet Volume, MPV/PC - Mean Platelet Volume-to-Platelet Count Ratio, Derived (d-)NLR ratio - neutrophil count divided by the result of white blood cell (WBC) count – neutrophil count), N/LP - Neutrophil count x 100/Lymphocyte count x Platelet count, CLR – C-reactive protein (CRP)-to-Lymphocyte Ratio, CPR - CRP-to-Platelet Ratio, LLR - Lactate dehydrogenase (LDH)-to-Lymphocyte Ratio, Systemic Immune Inflammation Index (SII) - platelet x neutrophil/lymphocyte count, Systemic Inflammation Response Index (SIRI) - neutrophil x monocyte/lymphocyte count] were investigated. White blood cell and neutrophil counts were significantly higher, while lymphocyte and platelet counts were significantly lower in nonsurvivors. MPV, MPV/PC, NLR, d-NLR, MLR, N/LP, CRP, LDH, CPR, CLR, LLR, SII, and SIRI values were significantly higher in nonsurvivors. Monocyte count and PLR values did not differ significantly between groups. Albumin-based ratios included CRP-to-Albumin Ratio (CAR), Lactate-to-Albumin Ratio (LAR) and LDH-to-Albumin Ratio (LDH/ALB). All values were significantly higher in nonsurvivors.Conclusion: The only independent predictor of lethal outcomes at ICU admission is the albumin-based LDH/ALB ratio. Most of the other parameters were moderate, although highly significant predictors of mortality in critically ill COVID-19 patients.Keywords: LDH/albumin ratio, critically ill, COVID-19, mortality |
| format | Article |
| id | doaj-art-04d0ac76964647999d13e33138b85b62 |
| institution | Kabale University |
| issn | 1178-7031 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj-art-04d0ac76964647999d13e33138b85b622025-01-05T16:36:04ZengDove Medical PressJournal of Inflammation Research1178-70312025-01-01Volume 18739098936Immune Cell-Based versus Albumin-Based Ratios as Outcome Predictors in Critically Ill COVID-19 PatientsZeba SSurbatovic MUdovicic IStanojevic IVojvodic DRondovic GMladenovic KAbazovic THasanovic AIlic ANAbazovic DKhan WDjordjevic DSnjezana Zeba,1 Maja Surbatovic,2 Ivo Udovicic,1 Ivan Stanojevic,3 Danilo Vojvodic,3 Goran Rondovic,1 Katarina Mladenovic,1 Tanja Abazovic,2 Almina Hasanovic,4 Aleksandra N Ilic,5 Dzihan Abazovic,6 Wasim Khan,7 Dragan Djordjevic1 1Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy, Faculty of Medicine of the Military Medical Academy, University of Defense, Belgrade, Serbia; 2Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy, Belgrade, Serbia; 3Institute for Medical Research, Military Medical Academy, Faculty of Medicine of the Military Medical Academy, University of Defense, Belgrade, Serbia; 4Nephrology Clinic, Military Medical Academy, Belgrade, Serbia; 5Faculty of Medicine, University of Pristina, Kosovska Mitrovica, Serbia; 6Atlas Hospital, Belgrade, Serbia, Aba Medica Healthcare Centre, Ulcinj, Montenegro; 7Division of Trauma & Orthopaedic Surgery, University of Cambridge, Addenbrooke’s Hospital, Cambridge, CB2 2QQ, UKCorrespondence: Maja Surbatovic, Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy, 17 Crnotravska Street, Belgrade, 11000, Serbia, Tel +381 11 2665 125, Email maja.surbatovic@gmail.comPurpose: The aim of the retrospective, single-center study was to assess the prognostic value of immune cell-based and albumin-based ratios regarding lethal outcome in critically ill COVID-19 patients.Patients and Methods: We analyzed 612 adult critically ill COVID-19 patients admitted to the intensive care unit (ICU) between April 2020 and November 2022. Blood measurement on admission to the ICU encompassed complete blood count (CBC), IL-6, C-reactive protein (CRP), albumin, lactate, lactate dehydrogenase (LDH), serum bicarbonate, arterial base deficit/excess (BD/E), and D-dimer. All the measured and calculated parameters were compared between survivors and nonsurvivors, with the outcome measure being hospital mortality.Results: Immune cell-based ratios [NLR - Neutrophil-to-Lymphocyte Ratio, MLR - Monocyte-to-Lymphocyte Ratio, PLR - Platelet-to-Lymphocyte Ratio, MPV - Mean Platelet Volume, MPV/PC - Mean Platelet Volume-to-Platelet Count Ratio, Derived (d-)NLR ratio - neutrophil count divided by the result of white blood cell (WBC) count – neutrophil count), N/LP - Neutrophil count x 100/Lymphocyte count x Platelet count, CLR – C-reactive protein (CRP)-to-Lymphocyte Ratio, CPR - CRP-to-Platelet Ratio, LLR - Lactate dehydrogenase (LDH)-to-Lymphocyte Ratio, Systemic Immune Inflammation Index (SII) - platelet x neutrophil/lymphocyte count, Systemic Inflammation Response Index (SIRI) - neutrophil x monocyte/lymphocyte count] were investigated. White blood cell and neutrophil counts were significantly higher, while lymphocyte and platelet counts were significantly lower in nonsurvivors. MPV, MPV/PC, NLR, d-NLR, MLR, N/LP, CRP, LDH, CPR, CLR, LLR, SII, and SIRI values were significantly higher in nonsurvivors. Monocyte count and PLR values did not differ significantly between groups. Albumin-based ratios included CRP-to-Albumin Ratio (CAR), Lactate-to-Albumin Ratio (LAR) and LDH-to-Albumin Ratio (LDH/ALB). All values were significantly higher in nonsurvivors.Conclusion: The only independent predictor of lethal outcomes at ICU admission is the albumin-based LDH/ALB ratio. Most of the other parameters were moderate, although highly significant predictors of mortality in critically ill COVID-19 patients.Keywords: LDH/albumin ratio, critically ill, COVID-19, mortalityhttps://www.dovepress.com/immune-cell-based-versus-albumin-based-ratios-as-outcome-predictors-in-peer-reviewed-fulltext-article-JIRldh/albumin ratiocritically illcovid-19mortality |
| spellingShingle | Zeba S Surbatovic M Udovicic I Stanojevic I Vojvodic D Rondovic G Mladenovic K Abazovic T Hasanovic A Ilic AN Abazovic D Khan W Djordjevic D Immune Cell-Based versus Albumin-Based Ratios as Outcome Predictors in Critically Ill COVID-19 Patients Journal of Inflammation Research ldh/albumin ratio critically ill covid-19 mortality |
| title | Immune Cell-Based versus Albumin-Based Ratios as Outcome Predictors in Critically Ill COVID-19 Patients |
| title_full | Immune Cell-Based versus Albumin-Based Ratios as Outcome Predictors in Critically Ill COVID-19 Patients |
| title_fullStr | Immune Cell-Based versus Albumin-Based Ratios as Outcome Predictors in Critically Ill COVID-19 Patients |
| title_full_unstemmed | Immune Cell-Based versus Albumin-Based Ratios as Outcome Predictors in Critically Ill COVID-19 Patients |
| title_short | Immune Cell-Based versus Albumin-Based Ratios as Outcome Predictors in Critically Ill COVID-19 Patients |
| title_sort | immune cell based versus albumin based ratios as outcome predictors in critically ill covid 19 patients |
| topic | ldh/albumin ratio critically ill covid-19 mortality |
| url | https://www.dovepress.com/immune-cell-based-versus-albumin-based-ratios-as-outcome-predictors-in-peer-reviewed-fulltext-article-JIR |
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