Dietary lipids shape cytokine and leptin profiles in obesity-metabolic syndrome implications: A cross-sectional study.
<h4>Background</h4>Obesity, characterized by chronic energy imbalance and excessive adiposity, is a key component of metabolic syndrome and is associated with low-grade inflammation and altered adipokine secretion. This study aimed to evaluate the association between dietary fat consumpt...
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2024-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0315711 |
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| author | Sakawrut Poosri Karani Santhanakrishnan Vimaleswaran Pattaneeya Prangthip |
| author_facet | Sakawrut Poosri Karani Santhanakrishnan Vimaleswaran Pattaneeya Prangthip |
| author_sort | Sakawrut Poosri |
| collection | DOAJ |
| description | <h4>Background</h4>Obesity, characterized by chronic energy imbalance and excessive adiposity, is a key component of metabolic syndrome and is associated with low-grade inflammation and altered adipokine secretion. This study aimed to evaluate the association between dietary fat consumption and its influence on interleukin (IL) and leptin levels in participants with obesity.<h4>Methods</h4>Using the Asian obesity classification criteria, a cross-sectional study was conducted on 384 adults (18-59 years). Anthropometric measurements by bioelectrical impedance analyzer (BIA), blood biochemistry by colorimetric assay, inflammatory markers and hormones by ELISA test, and dietary intake were assessed by Semi-FFQ.<h4>Results</h4>Obesity prevalence was 26.1% and 73.90% in males and females, respectively. Participants with obesity exhibited significantly higher inflammatory and hormonal marker levels. Positive correlations were observed between blood lipid, glucose, and tumor necrosis factor-α, IL-6, and leptin levels. Energy, carbohydrate, and sugar intake were positively correlated with leptin levels. High saturated fat intake was associated with increased IL-6 levels (odds ratio = 2.03, 95% confidence interval [CI] = 1.00-4.11, p < 0.047), whereas high total fat intake elevated leptin levels by 2.14-fold (95% CI = 1.12-4.10, p < 0.021) in participants with obesity.<h4>Conclusions</h4>This study demonstrates significant associations between dietary fat composition, inflammatory markers, and leptin levels in individuals with obesity. These findings suggest that modulating dietary fat intake can be a potential strategy for mitigating obesity-related inflammation and leptin resistance, highlighting the need for targeted nutritional interventions in obesity and metabolic syndrome management. |
| format | Article |
| id | doaj-art-04d03fab50ea4cb59d22f5f35725fbae |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-04d03fab50ea4cb59d22f5f35725fbae2025-01-08T05:33:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011912e031571110.1371/journal.pone.0315711Dietary lipids shape cytokine and leptin profiles in obesity-metabolic syndrome implications: A cross-sectional study.Sakawrut PoosriKarani Santhanakrishnan VimaleswaranPattaneeya Prangthip<h4>Background</h4>Obesity, characterized by chronic energy imbalance and excessive adiposity, is a key component of metabolic syndrome and is associated with low-grade inflammation and altered adipokine secretion. This study aimed to evaluate the association between dietary fat consumption and its influence on interleukin (IL) and leptin levels in participants with obesity.<h4>Methods</h4>Using the Asian obesity classification criteria, a cross-sectional study was conducted on 384 adults (18-59 years). Anthropometric measurements by bioelectrical impedance analyzer (BIA), blood biochemistry by colorimetric assay, inflammatory markers and hormones by ELISA test, and dietary intake were assessed by Semi-FFQ.<h4>Results</h4>Obesity prevalence was 26.1% and 73.90% in males and females, respectively. Participants with obesity exhibited significantly higher inflammatory and hormonal marker levels. Positive correlations were observed between blood lipid, glucose, and tumor necrosis factor-α, IL-6, and leptin levels. Energy, carbohydrate, and sugar intake were positively correlated with leptin levels. High saturated fat intake was associated with increased IL-6 levels (odds ratio = 2.03, 95% confidence interval [CI] = 1.00-4.11, p < 0.047), whereas high total fat intake elevated leptin levels by 2.14-fold (95% CI = 1.12-4.10, p < 0.021) in participants with obesity.<h4>Conclusions</h4>This study demonstrates significant associations between dietary fat composition, inflammatory markers, and leptin levels in individuals with obesity. These findings suggest that modulating dietary fat intake can be a potential strategy for mitigating obesity-related inflammation and leptin resistance, highlighting the need for targeted nutritional interventions in obesity and metabolic syndrome management.https://doi.org/10.1371/journal.pone.0315711 |
| spellingShingle | Sakawrut Poosri Karani Santhanakrishnan Vimaleswaran Pattaneeya Prangthip Dietary lipids shape cytokine and leptin profiles in obesity-metabolic syndrome implications: A cross-sectional study. PLoS ONE |
| title | Dietary lipids shape cytokine and leptin profiles in obesity-metabolic syndrome implications: A cross-sectional study. |
| title_full | Dietary lipids shape cytokine and leptin profiles in obesity-metabolic syndrome implications: A cross-sectional study. |
| title_fullStr | Dietary lipids shape cytokine and leptin profiles in obesity-metabolic syndrome implications: A cross-sectional study. |
| title_full_unstemmed | Dietary lipids shape cytokine and leptin profiles in obesity-metabolic syndrome implications: A cross-sectional study. |
| title_short | Dietary lipids shape cytokine and leptin profiles in obesity-metabolic syndrome implications: A cross-sectional study. |
| title_sort | dietary lipids shape cytokine and leptin profiles in obesity metabolic syndrome implications a cross sectional study |
| url | https://doi.org/10.1371/journal.pone.0315711 |
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