Hemolytic Transfusion Reaction due to Anti Jk Antibody, a Frequently Transient and Low‐Titer Antibody Probably Not Detected in Pretransfusion Testing; A Case Report
ABSTRACT This case report describes the management of a middle‐aged woman with abnormal uterine bleeding who developed Anti‐Jk and Anti‐M antibodies following multiple transfusions, illustrating the challenges in transfusion medicine. Despite initial negative antibody screening, repeat testing post‐...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-08-01
|
| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.70696 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849229067056840704 |
|---|---|
| author | Samaneh Salarvand Aysan Nozheh Alireza Abdollahi Hassan Sohrabinia |
| author_facet | Samaneh Salarvand Aysan Nozheh Alireza Abdollahi Hassan Sohrabinia |
| author_sort | Samaneh Salarvand |
| collection | DOAJ |
| description | ABSTRACT This case report describes the management of a middle‐aged woman with abnormal uterine bleeding who developed Anti‐Jk and Anti‐M antibodies following multiple transfusions, illustrating the challenges in transfusion medicine. Despite initial negative antibody screening, repeat testing post‐transfusion revealed these clinically significant antibodies, demonstrating the dynamic nature of alloimmunization. The case highlights the importance of the MNS and Kidd blood group systems in transfusion reactions, particularly the risk of delayed hemolysis with anti‐Jk antibodies. Through serial antibody screening, advanced serological techniques, and close blood bank collaboration, antigen‐negative blood was successfully provided for her urgent surgical needs. This report emphasizes the critical need for vigilant antibody monitoring in multitransfused patients, the value of interdisciplinary coordination, and the importance of ongoing clinician education to improve transfusion safety in complex cases. |
| format | Article |
| id | doaj-art-04c83461b2a0495d9db29011e463ddfc |
| institution | Kabale University |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-04c83461b2a0495d9db29011e463ddfc2025-08-22T07:33:07ZengWileyClinical Case Reports2050-09042025-08-01138n/an/a10.1002/ccr3.70696Hemolytic Transfusion Reaction due to Anti Jk Antibody, a Frequently Transient and Low‐Titer Antibody Probably Not Detected in Pretransfusion Testing; A Case ReportSamaneh Salarvand0Aysan Nozheh1Alireza Abdollahi2Hassan Sohrabinia3Department of Pathology Imam Khomeini Hospital Complex, Tehran University of Medical Sciences Tehran IranDepartment of Pathology Imam Khomeini Hospital Complex, Tehran University of Medical Sciences Tehran IranDepartment of Pathology Imam Khomeini Hospital Complex, Tehran University of Medical Sciences Tehran IranBA in Medical Laboratory, Central Laboratory of Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran IranABSTRACT This case report describes the management of a middle‐aged woman with abnormal uterine bleeding who developed Anti‐Jk and Anti‐M antibodies following multiple transfusions, illustrating the challenges in transfusion medicine. Despite initial negative antibody screening, repeat testing post‐transfusion revealed these clinically significant antibodies, demonstrating the dynamic nature of alloimmunization. The case highlights the importance of the MNS and Kidd blood group systems in transfusion reactions, particularly the risk of delayed hemolysis with anti‐Jk antibodies. Through serial antibody screening, advanced serological techniques, and close blood bank collaboration, antigen‐negative blood was successfully provided for her urgent surgical needs. This report emphasizes the critical need for vigilant antibody monitoring in multitransfused patients, the value of interdisciplinary coordination, and the importance of ongoing clinician education to improve transfusion safety in complex cases.https://doi.org/10.1002/ccr3.70696anti‐jk antibodiesanti‐m antibodiesblood bank managementhemolytic transfusion reactionskidd blood group systemMNS blood group system |
| spellingShingle | Samaneh Salarvand Aysan Nozheh Alireza Abdollahi Hassan Sohrabinia Hemolytic Transfusion Reaction due to Anti Jk Antibody, a Frequently Transient and Low‐Titer Antibody Probably Not Detected in Pretransfusion Testing; A Case Report Clinical Case Reports anti‐jk antibodies anti‐m antibodies blood bank management hemolytic transfusion reactions kidd blood group system MNS blood group system |
| title | Hemolytic Transfusion Reaction due to Anti Jk Antibody, a Frequently Transient and Low‐Titer Antibody Probably Not Detected in Pretransfusion Testing; A Case Report |
| title_full | Hemolytic Transfusion Reaction due to Anti Jk Antibody, a Frequently Transient and Low‐Titer Antibody Probably Not Detected in Pretransfusion Testing; A Case Report |
| title_fullStr | Hemolytic Transfusion Reaction due to Anti Jk Antibody, a Frequently Transient and Low‐Titer Antibody Probably Not Detected in Pretransfusion Testing; A Case Report |
| title_full_unstemmed | Hemolytic Transfusion Reaction due to Anti Jk Antibody, a Frequently Transient and Low‐Titer Antibody Probably Not Detected in Pretransfusion Testing; A Case Report |
| title_short | Hemolytic Transfusion Reaction due to Anti Jk Antibody, a Frequently Transient and Low‐Titer Antibody Probably Not Detected in Pretransfusion Testing; A Case Report |
| title_sort | hemolytic transfusion reaction due to anti jk antibody a frequently transient and low titer antibody probably not detected in pretransfusion testing a case report |
| topic | anti‐jk antibodies anti‐m antibodies blood bank management hemolytic transfusion reactions kidd blood group system MNS blood group system |
| url | https://doi.org/10.1002/ccr3.70696 |
| work_keys_str_mv | AT samanehsalarvand hemolytictransfusionreactionduetoantijkantibodyafrequentlytransientandlowtiterantibodyprobablynotdetectedinpretransfusiontestingacasereport AT aysannozheh hemolytictransfusionreactionduetoantijkantibodyafrequentlytransientandlowtiterantibodyprobablynotdetectedinpretransfusiontestingacasereport AT alirezaabdollahi hemolytictransfusionreactionduetoantijkantibodyafrequentlytransientandlowtiterantibodyprobablynotdetectedinpretransfusiontestingacasereport AT hassansohrabinia hemolytictransfusionreactionduetoantijkantibodyafrequentlytransientandlowtiterantibodyprobablynotdetectedinpretransfusiontestingacasereport |