Associations Between Mosaic Loss of Sex Chromosomes and Incident Hospitalization for Atrial Fibrillation in the United Kingdom

Associations Between Mosaic Loss of Sex Chromosomes and Incident Hospitalization for Atrial Fibrillation in the United Kingdom

Background Mosaic loss of chromosome Y (mLOY) in leukocytes of men reflects genomic instability from aging, smoking, and environmental exposures. A similar mosaic loss of chromosome X (mLOX) occurs among women. However, the associations between mLOY, mLOX, and risk of incident heart diseases are unc...

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Bibliographic Details
Main Authors: Jungeun Lim, Aubrey K. Hubbard, Batel Blechter, Jianxin Shi, Weiyin Zhou, Erikka Loftfield, Mitchell J. Machiela, Jason Y.Y. Wong
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
atrial fibrillation
heart disease
incident relative risk
mosaic loss of sex chromosomes
prospective cohort study
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.036984
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https://www.ahajournals.org/doi/10.1161/JAHA.124.036984

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