Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer

Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer

Chemoresistance to 5-fluorouracil (5-FU) is a significant challenge in treating colorectal cancer (CRC). Novel combined regimens to thwart chemoresistance are therefore urgently needed. Herein, we demonstrated that the combination of Avenanthramide A (AVN A) and 5-FU has significant therapeutic adva...

Full description

Saved in:

Bibliographic Details
Main Authors:	Rong Fu, Zhangfeng Dou, Ning Li, Xueyuan Fan, Sajid Amin, Jinqi Zhang, Yuqing Wang, Zongwei Li, Zhuoyu Li, Peng Yang
Format:	Article
Language:	English
Published:	Elsevier 2024-12-01
Series:	Acta Pharmaceutica Sinica B
Subjects:	Avenanthramide A 5-Fluorouracil KDM4C Colorectal cancer MIR17HG
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383524002922
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Diversity of avenanthramide content in wild and cultivated oats
by: S. Leonova, et al.
Published: (2020-04-01)

The effects of processing steps on avenanthramides, avenacosides and β-glucan content during the production of oat-based milk alternatives
by: Roisin McCarron, et al.
Published: (2025-03-01)

The histone demethylase Kdm5 controls Hid-induced cell death in Drosophila
by: Hans-Martin Herz, et al.
Published: (2024-11-01)

The histone demethylase KDM5C enhances the sensitivity of acute myeloid leukemia cells to lenalidomide by stabilizing cereblon
by: Lu Zou, et al.
Published: (2025-01-01)

N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis
by: Haisheng Zhang, et al.
Published: (2025-01-01)

HPV11 targeting KDM4A regulates the polarization of macrophage M1 and promotes the development of nasal inverted papilloma
by: Liying Zheng, et al.
Published: (2024-12-01)

Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusion
by: Mehmet Erdem Çakmak, et al.
Published: (2024-08-01)

Risk factors for fluorouracil-induced cardiotoxicity in patients with gastrointestinal tumor
by: Yuting Wu, et al.
Published: (2025-02-01)

Influence of the skeletal muscle index on pharmacokinetics and toxicity of fluorouracil
by: Eduard Schmulenson, et al.
Published: (2023-02-01)

Hg, Cd, As, and Pb in surface sediments from the tropical coastal lagoon Estero Salado, Gulf of Guayaquil-Ecuador
by: Franklin I. Ormaza-González, et al.
Published: (2024-12-01)

5-Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan as a Potential Standard for Second-line Therapy in Extrapulmonary Neuroendocrine Carcinomas
by: I-Wei Ho, et al.
Published: (2024-12-01)

Influence of NH3 on Hg0 Oxidation Performance of SCR Catalyst
by: Qiyu WENG, et al.
Published: (2020-10-01)

Salidroside enhances 5-fluorouracil sensitivity against hepatocellular carcinoma via YIPF5-induced mitophagy
by: Sumin Sun, et al.
Published: (2025-01-01)

Clinical Features and Genetic Characteristics of XLID Patients With KDM5C Gene Mutations: Insights on Phenotype–Genotype Correlations From 175 Previous Cases and Identification of a Novel Variant
by: Mohammad‐Reza Ghasemi, et al.
Published: (2025-01-01)

Topical 5-fluorouracil application in management of odontogenic keratocysts
by: Parveen Akhter Lone, et al.
Published: (2020-10-01)

Chitosan nanocarriers: Pioneering encapsulation and targeted delivery of 5-fluorouracil - A comprehensive review
by: Mariyeh Rajaei, et al.
Published: (2024-12-01)

Combination Therapy of 5-Fluorouracil and Triamcinolone Acetonide with Compression Therapy after Surgical Excision in the Management of Keloids in Ears
by: Randeep Singh Lamba, et al.

Cyclodextrin nanocarriers in Coordination Chemistry: Enhancing encapsulation and targeted delivery of 5-Fluorouracil for cancer treatment
by: Sara Payamifar, et al.
Published: (2024-12-01)

Exploring the efficacy of fluorouracil and platinum based chemotherapy in advanced hepatocellular carcinoma to bridge the treatment gap in resource limited settings
by: Se Jun Park, et al.
Published: (2025-01-01)

Mutation of lysine-specific demethylase 5 is associated with enhanced tumor immunity and favorable outcomes in pan-cancer immune checkpoint blockade
by: Xiaofeng Li, et al.
Published: (2024-12-01)

<i>Bacillus clausii</i> Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice
by: Francisco Ronaldo Farias Lima, et al.
Published: (2024-12-01)

SNPs and blood inflammatory marker featured machine learning for predicting the efficacy of fluorouracil-based chemotherapy in colorectal cancer
by: Jiyifan Li, et al.
Published: (2024-11-01)

Comparative Evaluation of the Preventive Effects of Citral, Silymarin, Thymoquinone, and Curcumin on 5-Fluorouracil-Induced Cardiac and Pulmonary Toxicity in Rats
by: Tohid Zahed, et al.
Published: (2024-12-01)

5-Fluorouracil-β-Cyclodextrin conjugates:Linker strategies to enhance the anticancer efficacy and reduce the side effects
by: Liangliang Hu, et al.
Published: (2025-03-01)

Gut virome dysbiosis impairs antitumor immunity and reduces 5-fluorouracil treatment efficacy for colorectal cancer
by: Hui Huang, et al.
Published: (2024-12-01)

High‐Load Core@Shell Nanocarriers with Irinotecan and 5‐Fluorouracil for Combination Chemotherapy in Colorectal Cancer
by: Silke Notter, et al.
Published: (2024-11-01)

Total mercury and methylmercury levels in Brazilian Amazon fish: A scope review with meta-analysis and local population health risk assessment
by: Milena Dutra Pierezan, et al.
Published: (2024-12-01)

An Assessment of Surface Contamination and Dermal Exposure to 5-Fluorouracil in Healthcare Settings by UPLC-MS/MS Using a New Atmospheric Pressure Ionization Source
by: Matteo Creta, et al.
Published: (2024-10-01)

Toxicity of Mercury
by: A. Barış Akcan, et al.
Published: (2008-10-01)

Jiedu Xiaozheng Decoction Augments 5-fluorouracil Induced Anti-hepatic Carcinoma Effect <italic>in Vitro</italic> and <italic>in Vivo</italic>
by: Zhiyun CAO, et al.
Published: (2019-02-01)

Potential effects of adenosine triphosphate and melatonin on oxidative and inflammatory optic nerve damage in rats caused by 5-fluorouracil
by: Ahmet Mehmet Somuncu, et al.
Published: (2025-02-01)

5-Fluorouracil Inhibits Bacterial Growth and Reduces Biofilm in Addition to Having Synergetic Effects with Gentamicin Against <i>Pseudomonas aeruginosa</i>
by: Amani A. Niazy, et al.
Published: (2024-11-01)

Assessment of MIR3142HG genetic polymorphisms and the susceptibility of lumbar disc herniation in the Chinese population
by: Qi Dong, et al.
Published: (2024-11-01)

Gold nanoparticle encapsulated hybrid MOF: synthesis, characterization, and co-drug delivery of 5-fluorouracil and curcumin
by: Pranita Rananaware, et al.
Published: (2024-12-01)

Nitrogen and boron co-doped carbon dots probe for selectively detecting Hg2+ in water samples and the detection mechanism
by: Qiu Lixin, et al.
Published: (2024-12-01)

Combinational delivery of berbamine and 5-fluorouracil in cerium oxide nanoparticles for colon cancer therapy: Insights from in vitro and in silico studies
by: Sneha Shriparna Satpathy, et al.
Published: (2024-12-01)

LncRNA MIR210HG promotes the proliferation of colon cancer cells by inhibiting ferroptosis through binding to PCBP1
by: Xiao-Qian Wang, et al.
Published: (2025-01-01)

Comparative Efficacy and Tolerability of Imiquimod 3.75% Cream vs 5-Fluorouracil 4% cream in the Treatment of Actinic Keratosis: A Split-Face Study
by: Cesare Ariasi, et al.
Published: (2025-01-01)

Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes
by: Zongheng Wang, et al.
Published: (2025-01-01)

Treatment of false‐negative metastatic lymph nodes by a lymphatic drug delivery system with 5‐fluorouracil
by: Honoka Fujii, et al.
Published: (2019-05-01)