Correlation of pregnancy duration with hemoglobin, Ret-He, IL-6, activin B, and hepcidin levels in healthy women
Background and objectives. Hepcidin levels always change during pregnancy, resulting in changes in iron hemostasis. Therefore, this study aims to determine the relationship between length of pregnancy and concentrations of hemoglobin, Ret-He, IL-6, activin B and hepcidin in normal pregnant women. Ma...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2024-06-01
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| Series: | Romanian Medical Journal |
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| Online Access: | https://rmj.com.ro/articles/2024.2/RMJ_2024_2_Art-14.pdf |
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| _version_ | 1846111231392350208 |
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| author | Gilang Nugraha Mohammad Nasir |
| author_facet | Gilang Nugraha Mohammad Nasir |
| author_sort | Gilang Nugraha |
| collection | DOAJ |
| description | Background and objectives. Hepcidin levels always change during pregnancy, resulting in changes in iron hemostasis. Therefore, this study aims to determine the relationship between length of pregnancy and concentrations of hemoglobin, Ret-He, IL-6, activin B and hepcidin in normal pregnant women. Materials and methods. A cross-sectional study was conducted at Jagir Community Health Center. A total of 30 pregnant women were respondents. Hemoglobin and Ret-He levels were measured using a hematology analyzer. IL-6, activin B and hepcidin were measured using ELISA. Results. The results showed that there was a significant difference between the adherent and non-compliant groups in consuming iron supplements on hemoglobin levels (p=0.0042) and IL-6 (p=0.019), while there was no difference in Ret-He levels (p=0.151), activin B (p=0.854) and hepcidin (p=0.189). There was a correlation between gestational age and IL-6 (r=0.207; p=0.273), activin B (r=0.15; p=0.121) and hepcidin (r=0.096; p=0.614). However, there was a negative correlation with hemoglobin (r=0.483; p=0.007) and Ret-He (r=0.505; p=0.004). Conclusion. It was concluded that increasing gestational age will result in a decrease in hemoglobin levels and a decrease in body iron reserves. However, pregnant women who comply with iron supplementation have at least high hemoglobin levels and low IL-6 levels. |
| format | Article |
| id | doaj-art-047143909bce4b0baf9a2e001a55df17 |
| institution | Kabale University |
| issn | 1220-5478 2069-606X |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Medical Journal |
| spelling | doaj-art-047143909bce4b0baf9a2e001a55df172024-12-23T08:34:41ZengAmaltea Medical Publishing HouseRomanian Medical Journal1220-54782069-606X2024-06-0171215115510.37897/RMJ.2024.2.14Correlation of pregnancy duration with hemoglobin, Ret-He, IL-6, activin B, and hepcidin levels in healthy womenGilang Nugraha0Mohammad Nasir1Department of Medical Laboratory Technology, Faculty of Health, Universitas Nahdlatul Ulama Surabaya, Surabaya, IndonesiaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universitas Nahdlatul Ulama Surabaya, Surabaya, IndonesiaBackground and objectives. Hepcidin levels always change during pregnancy, resulting in changes in iron hemostasis. Therefore, this study aims to determine the relationship between length of pregnancy and concentrations of hemoglobin, Ret-He, IL-6, activin B and hepcidin in normal pregnant women. Materials and methods. A cross-sectional study was conducted at Jagir Community Health Center. A total of 30 pregnant women were respondents. Hemoglobin and Ret-He levels were measured using a hematology analyzer. IL-6, activin B and hepcidin were measured using ELISA. Results. The results showed that there was a significant difference between the adherent and non-compliant groups in consuming iron supplements on hemoglobin levels (p=0.0042) and IL-6 (p=0.019), while there was no difference in Ret-He levels (p=0.151), activin B (p=0.854) and hepcidin (p=0.189). There was a correlation between gestational age and IL-6 (r=0.207; p=0.273), activin B (r=0.15; p=0.121) and hepcidin (r=0.096; p=0.614). However, there was a negative correlation with hemoglobin (r=0.483; p=0.007) and Ret-He (r=0.505; p=0.004). Conclusion. It was concluded that increasing gestational age will result in a decrease in hemoglobin levels and a decrease in body iron reserves. However, pregnant women who comply with iron supplementation have at least high hemoglobin levels and low IL-6 levels.https://rmj.com.ro/articles/2024.2/RMJ_2024_2_Art-14.pdfinflammatory statushemoglobinhepcidinpregnancy durationret-he |
| spellingShingle | Gilang Nugraha Mohammad Nasir Correlation of pregnancy duration with hemoglobin, Ret-He, IL-6, activin B, and hepcidin levels in healthy women Romanian Medical Journal inflammatory status hemoglobin hepcidin pregnancy duration ret-he |
| title | Correlation of pregnancy duration with hemoglobin, Ret-He, IL-6, activin B, and hepcidin levels in healthy women |
| title_full | Correlation of pregnancy duration with hemoglobin, Ret-He, IL-6, activin B, and hepcidin levels in healthy women |
| title_fullStr | Correlation of pregnancy duration with hemoglobin, Ret-He, IL-6, activin B, and hepcidin levels in healthy women |
| title_full_unstemmed | Correlation of pregnancy duration with hemoglobin, Ret-He, IL-6, activin B, and hepcidin levels in healthy women |
| title_short | Correlation of pregnancy duration with hemoglobin, Ret-He, IL-6, activin B, and hepcidin levels in healthy women |
| title_sort | correlation of pregnancy duration with hemoglobin ret he il 6 activin b and hepcidin levels in healthy women |
| topic | inflammatory status hemoglobin hepcidin pregnancy duration ret-he |
| url | https://rmj.com.ro/articles/2024.2/RMJ_2024_2_Art-14.pdf |
| work_keys_str_mv | AT gilangnugraha correlationofpregnancydurationwithhemoglobinretheil6activinbandhepcidinlevelsinhealthywomen AT mohammadnasir correlationofpregnancydurationwithhemoglobinretheil6activinbandhepcidinlevelsinhealthywomen |