Effects of vitamin D supplementation on cardiac biomarkers: Results from the STURDY trial
Objectives: In observational studies, older adults with low serum vitamin D levels are at higher risk of cardiovascular disease (CVD), but randomized trials have failed to demonstrate reduction in CVD risk from vitamin D supplementation, possibly because the doses of vitamin D supplements tested wer...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | American Journal of Preventive Cardiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666667724002393 |
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| author | Katharine W Rainer William Earle Erin D Michos Edgar R Miller, 3rd Amal A Wanigatunga Heather Rebuck Robert Christensen Jennifer A Schrack Christine M Mitchell Rita R Kalyani Lawrence J Appel Stephen P Juraschek |
| author_facet | Katharine W Rainer William Earle Erin D Michos Edgar R Miller, 3rd Amal A Wanigatunga Heather Rebuck Robert Christensen Jennifer A Schrack Christine M Mitchell Rita R Kalyani Lawrence J Appel Stephen P Juraschek |
| author_sort | Katharine W Rainer |
| collection | DOAJ |
| description | Objectives: In observational studies, older adults with low serum vitamin D levels are at higher risk of cardiovascular disease (CVD), but randomized trials have failed to demonstrate reduction in CVD risk from vitamin D supplementation, possibly because the doses of vitamin D supplements tested were too low. Our objective was to determine if higher doses of vitamin D supplementation reduce high-sensitivity cardiac troponin (hs-cTnI) and N-terminal pro-b-type natriuretic peptide (NT-proBNP), markers of subclinical CVD. Methods: The Study to Understand Fall Reduction and Vitamin D in You (STURDY) was a double-blind, randomized, response-adaptive trial that tested the effects of 4 doses of vitamin D3 supplementation (200, 1000, 2000, 4000 IU/day) on fall risk among older adults with low serum 25-hydroxyvitamin D concentrations (10–29 ng/mL). Hs-cTnI and NT-proBNP levels were measured at baseline, 3-, 12-, and 24-month follow-up visits. For this ancillary study, we used data from the original trial and compared participants by treatment group: low-dose (200 IU/day) or high-dose (1000+ IU/day). The effects of vitamin D dose on biomarkers were assessed via mixed effects tobit models. Results: Among 688 participants (mean age of 76.5) hs-cTnI increased in both the low- and high-dose groups by 5.2 % and 7.0 %, respectively; likewise, NT-proBNP increased by 11.3 % and 9.3 %, respectively. Compared to the low-dose, high-dose vitamin D supplementation did not affect hs-cTnI (1.6 %-difference; 95 % CI: -5.3, 8.9) or NT-proBNP (-1.8 %-difference; 95 % CI: -9.3, 6.3). Conclusions: Compared to low-dose vitamin D supplementation, doses ≥1,000 IU/ day did not affect markers of subclinical CVD in older adults with low serum vitamin D levels. |
| format | Article |
| id | doaj-art-044d22c79ef74624b64a919adde8a821 |
| institution | Kabale University |
| issn | 2666-6677 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Preventive Cardiology |
| spelling | doaj-art-044d22c79ef74624b64a919adde8a8212024-12-11T05:57:43ZengElsevierAmerican Journal of Preventive Cardiology2666-66772024-12-0120100871Effects of vitamin D supplementation on cardiac biomarkers: Results from the STURDY trialKatharine W Rainer0William Earle1Erin D Michos2Edgar R Miller, 3rd3Amal A Wanigatunga4Heather Rebuck5Robert Christensen6Jennifer A Schrack7Christine M Mitchell8Rita R Kalyani9Lawrence J Appel10Stephen P Juraschek11Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USABeth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USAThe Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USAThe Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; The Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, Maryland, USAThe Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USAUniversity of Maryland School of Medicine, College Park, Maryland, USAUniversity of Maryland School of Medicine, College Park, Maryland, USAThe Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USAThe Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USAThe Johns Hopkins University School of Medicine, Baltimore, Maryland, USAThe Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; The Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, Maryland, USABeth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA; Corresponding author at: Beth Israel Deaconess Medical Center, Division of General Medicine, Section for Research, 330 Brookline Avenue, CO-1309, #216, Boston, MA 02215, USA.Objectives: In observational studies, older adults with low serum vitamin D levels are at higher risk of cardiovascular disease (CVD), but randomized trials have failed to demonstrate reduction in CVD risk from vitamin D supplementation, possibly because the doses of vitamin D supplements tested were too low. Our objective was to determine if higher doses of vitamin D supplementation reduce high-sensitivity cardiac troponin (hs-cTnI) and N-terminal pro-b-type natriuretic peptide (NT-proBNP), markers of subclinical CVD. Methods: The Study to Understand Fall Reduction and Vitamin D in You (STURDY) was a double-blind, randomized, response-adaptive trial that tested the effects of 4 doses of vitamin D3 supplementation (200, 1000, 2000, 4000 IU/day) on fall risk among older adults with low serum 25-hydroxyvitamin D concentrations (10–29 ng/mL). Hs-cTnI and NT-proBNP levels were measured at baseline, 3-, 12-, and 24-month follow-up visits. For this ancillary study, we used data from the original trial and compared participants by treatment group: low-dose (200 IU/day) or high-dose (1000+ IU/day). The effects of vitamin D dose on biomarkers were assessed via mixed effects tobit models. Results: Among 688 participants (mean age of 76.5) hs-cTnI increased in both the low- and high-dose groups by 5.2 % and 7.0 %, respectively; likewise, NT-proBNP increased by 11.3 % and 9.3 %, respectively. Compared to the low-dose, high-dose vitamin D supplementation did not affect hs-cTnI (1.6 %-difference; 95 % CI: -5.3, 8.9) or NT-proBNP (-1.8 %-difference; 95 % CI: -9.3, 6.3). Conclusions: Compared to low-dose vitamin D supplementation, doses ≥1,000 IU/ day did not affect markers of subclinical CVD in older adults with low serum vitamin D levels.http://www.sciencedirect.com/science/article/pii/S2666667724002393Vitamin DCardiac BiomarkersPreventative CardiologyCardiac InjuryCardiac StrainTroponin |
| spellingShingle | Katharine W Rainer William Earle Erin D Michos Edgar R Miller, 3rd Amal A Wanigatunga Heather Rebuck Robert Christensen Jennifer A Schrack Christine M Mitchell Rita R Kalyani Lawrence J Appel Stephen P Juraschek Effects of vitamin D supplementation on cardiac biomarkers: Results from the STURDY trial American Journal of Preventive Cardiology Vitamin D Cardiac Biomarkers Preventative Cardiology Cardiac Injury Cardiac Strain Troponin |
| title | Effects of vitamin D supplementation on cardiac biomarkers: Results from the STURDY trial |
| title_full | Effects of vitamin D supplementation on cardiac biomarkers: Results from the STURDY trial |
| title_fullStr | Effects of vitamin D supplementation on cardiac biomarkers: Results from the STURDY trial |
| title_full_unstemmed | Effects of vitamin D supplementation on cardiac biomarkers: Results from the STURDY trial |
| title_short | Effects of vitamin D supplementation on cardiac biomarkers: Results from the STURDY trial |
| title_sort | effects of vitamin d supplementation on cardiac biomarkers results from the sturdy trial |
| topic | Vitamin D Cardiac Biomarkers Preventative Cardiology Cardiac Injury Cardiac Strain Troponin |
| url | http://www.sciencedirect.com/science/article/pii/S2666667724002393 |
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