Evaluation of a single-use bioartificial liver (BAL) biocartridge consisting of cryopreservable alginate encapsulated liver cell spheroids as a component of HepatiCan™, a novel bioartificial liver device

Evaluation of a single-use bioartificial liver (BAL) biocartridge consisting of cryopreservable alginate encapsulated liver cell spheroids as a component of HepatiCan™, a novel bioartificial liver device

Introductionalternative therapies to complement liver transplantation and treat patients with liver failure are not available. In this study, a clinical scale single-use biocartridge was developed for use as part of a novel Bioartificial Liver device (HepatiCan™), utilising conditioned human-derived...

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Bibliographic Details
Main Authors: Eloy Erro, Tom Brookshaw, Barry Fuller, Sweta Chandel, Joana Mendonca da Silva, Elizaveta Zotova, Sherri-Ann Chalmers, Alfie Watt, Clare Selden
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
bioartificial liver (BAL)
single-use biocartridge
computational fluid dynamics (CFD)
alginate encapsulated liver spheroids (AELS)
cryopreservation
hydrodynamic conditions
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1572254/full
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