PLACE OF PHOTODYNAMIC THERAPY IN ORGAN-SPARING TREATMENT PROGRAMS FOR SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSA
The Medical Radiology Research Center Clinic performed photodynamic therapy (PDT) in 57 patients with cancer of the oral mucosa in the independent fashion. Pretreatment recurrent tumors were diagnosed in half (50.9 %) of the patients. Spectroscopy showed the therapeutic accumulation of the drug, whi...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2015-04-01
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| Series: | Опухоли головы и шеи |
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| Online Access: | https://ogsh.abvpress.ru/jour/article/view/24 |
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| author | V. V. Polkin M. A. Kaplan V. S. Medvedev D. Yu. Semin V. N. Kapinus I. S. Spichenkova P. A. Isayev D. N. Derbugov A. M. Shubina |
| author_facet | V. V. Polkin M. A. Kaplan V. S. Medvedev D. Yu. Semin V. N. Kapinus I. S. Spichenkova P. A. Isayev D. N. Derbugov A. M. Shubina |
| author_sort | V. V. Polkin |
| collection | DOAJ |
| description | The Medical Radiology Research Center Clinic performed photodynamic therapy (PDT) in 57 patients with cancer of the oral mucosa in the independent fashion. Pretreatment recurrent tumors were diagnosed in half (50.9 %) of the patients. Spectroscopy showed the therapeutic accumulation of the drug, which was 1.8–3 times greater than that in the skin and intact mucosa in the presence of a malignant neoplasm. Complete and partial tumor regression was achieved in 50 (87.7 %) and 4 (7 %) patients, respectively; stabilization was seen in 3 (5.3 %) patients. Three-year overall survival was 86.7 ± 5.2 % and three-year relapse-free survival was 70.5 ± 7.1 %. PDT has an organ-saving directionality, without causing functional and cosmetic impairments, thus showing its rather high effectiveness. |
| format | Article |
| id | doaj-art-03fcab7592f04faaa50d395160edbb7f |
| institution | Kabale University |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2015-04-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-03fcab7592f04faaa50d395160edbb7f2025-08-20T04:00:26ZrusABV-pressОпухоли головы и шеи2222-14682411-46342015-04-0101232710.17650/2222-1468-2012-0-1-23-2724PLACE OF PHOTODYNAMIC THERAPY IN ORGAN-SPARING TREATMENT PROGRAMS FOR SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSAV. V. Polkin0M. A. Kaplan1V. S. Medvedev2D. Yu. Semin3V. N. Kapinus4I. S. Spichenkova5P. A. Isayev6D. N. Derbugov7A. M. Shubina8Medical Radiology Research Center, Ministry of Health and Social Development of Russia, ObninskMedical Radiology Research Center, Ministry of Health and Social Development of Russia, ObninskMedical Radiology Research Center, Ministry of Health and Social Development of Russia, ObninskMedical Radiology Research Center, Ministry of Health and Social Development of Russia, ObninskMedical Radiology Research Center, Ministry of Health and Social Development of Russia, ObninskMedical Radiology Research Center, Ministry of Health and Social Development of Russia, ObninskMedical Radiology Research Center, Ministry of Health and Social Development of Russia, ObninskMedical Radiology Research Center, Ministry of Health and Social Development of Russia, ObninskMedical Radiology Research Center, Ministry of Health and Social Development of Russia, ObninskThe Medical Radiology Research Center Clinic performed photodynamic therapy (PDT) in 57 patients with cancer of the oral mucosa in the independent fashion. Pretreatment recurrent tumors were diagnosed in half (50.9 %) of the patients. Spectroscopy showed the therapeutic accumulation of the drug, which was 1.8–3 times greater than that in the skin and intact mucosa in the presence of a malignant neoplasm. Complete and partial tumor regression was achieved in 50 (87.7 %) and 4 (7 %) patients, respectively; stabilization was seen in 3 (5.3 %) patients. Three-year overall survival was 86.7 ± 5.2 % and three-year relapse-free survival was 70.5 ± 7.1 %. PDT has an organ-saving directionality, without causing functional and cosmetic impairments, thus showing its rather high effectiveness.https://ogsh.abvpress.ru/jour/article/view/24squamous cell carcinoma of the oral mucosaphotodynamic therapyphotosensitizerfluorescence diagnosis |
| spellingShingle | V. V. Polkin M. A. Kaplan V. S. Medvedev D. Yu. Semin V. N. Kapinus I. S. Spichenkova P. A. Isayev D. N. Derbugov A. M. Shubina PLACE OF PHOTODYNAMIC THERAPY IN ORGAN-SPARING TREATMENT PROGRAMS FOR SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSA Опухоли головы и шеи squamous cell carcinoma of the oral mucosa photodynamic therapy photosensitizer fluorescence diagnosis |
| title | PLACE OF PHOTODYNAMIC THERAPY IN ORGAN-SPARING TREATMENT PROGRAMS FOR SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSA |
| title_full | PLACE OF PHOTODYNAMIC THERAPY IN ORGAN-SPARING TREATMENT PROGRAMS FOR SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSA |
| title_fullStr | PLACE OF PHOTODYNAMIC THERAPY IN ORGAN-SPARING TREATMENT PROGRAMS FOR SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSA |
| title_full_unstemmed | PLACE OF PHOTODYNAMIC THERAPY IN ORGAN-SPARING TREATMENT PROGRAMS FOR SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSA |
| title_short | PLACE OF PHOTODYNAMIC THERAPY IN ORGAN-SPARING TREATMENT PROGRAMS FOR SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSA |
| title_sort | place of photodynamic therapy in organ sparing treatment programs for squamous cell carcinoma of the oral mucosa |
| topic | squamous cell carcinoma of the oral mucosa photodynamic therapy photosensitizer fluorescence diagnosis |
| url | https://ogsh.abvpress.ru/jour/article/view/24 |
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