Advances in Understanding Therapeutic Mechanisms of Exercise Interventions for Individuals with Comorbid Depression and Cardiovascular Diseases: A Narrative Review
The aims of this narrative review were to summarize the current literature on the beneficial effects of exercise interventions on individuals with comorbid depression and cardiovascular disease, and to review the current evidence that advances our understanding of the pathophysiological mechanisms u...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-11-01
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| Series: | Heart and Mind |
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| Online Access: | https://journals.lww.com/10.4103/hm.HM-D-24-00036 |
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| author | Xueqin Li Yumei Han Shi Zhou Jinfang Cheng |
| author_facet | Xueqin Li Yumei Han Shi Zhou Jinfang Cheng |
| author_sort | Xueqin Li |
| collection | DOAJ |
| description | The aims of this narrative review were to summarize the current literature on the beneficial effects of exercise interventions on individuals with comorbid depression and cardiovascular disease, and to review the current evidence that advances our understanding of the pathophysiological mechanisms underlying these effects. Ninety relevant articles were included and analyzed through a systematic search of PubMed and Web of Science. The analyses indicated that exercise interventions could modulate regulatory pathways to prevent depressive symptoms and reduce adverse cardiovascular events through five mechanisms: promoting immunosuppression, improving mitochondrial function, balancing the autonomic nervous system, up-regulating serum brain-derived neurotrophic factor, and improving vascular endothelial function; and the critical role of integrating the key principles of exercise prescription (frequency, intensity, type, time, volume, and progression) to identify novel therapeutic targets and optimize interventions. In conclusion, this study emphasizes not only the significance of exercise interventions but also the critical role of optimizing exercise prescriptions in managing comorbid depression and cardiovascular disorders. The approach holds important theoretical and clinical practice implications for enhancing both mental and cardiovascular health. |
| format | Article |
| id | doaj-art-03e178ceef6646e0aac2dfe1c9c9add5 |
| institution | Kabale University |
| issn | 2468-6476 2468-6484 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Heart and Mind |
| spelling | doaj-art-03e178ceef6646e0aac2dfe1c9c9add52024-12-09T08:36:42ZengWolters Kluwer Medknow PublicationsHeart and Mind2468-64762468-64842024-11-018429229910.4103/hm.HM-D-24-00036Advances in Understanding Therapeutic Mechanisms of Exercise Interventions for Individuals with Comorbid Depression and Cardiovascular Diseases: A Narrative ReviewXueqin LiYumei HanShi ZhouJinfang ChengThe aims of this narrative review were to summarize the current literature on the beneficial effects of exercise interventions on individuals with comorbid depression and cardiovascular disease, and to review the current evidence that advances our understanding of the pathophysiological mechanisms underlying these effects. Ninety relevant articles were included and analyzed through a systematic search of PubMed and Web of Science. The analyses indicated that exercise interventions could modulate regulatory pathways to prevent depressive symptoms and reduce adverse cardiovascular events through five mechanisms: promoting immunosuppression, improving mitochondrial function, balancing the autonomic nervous system, up-regulating serum brain-derived neurotrophic factor, and improving vascular endothelial function; and the critical role of integrating the key principles of exercise prescription (frequency, intensity, type, time, volume, and progression) to identify novel therapeutic targets and optimize interventions. In conclusion, this study emphasizes not only the significance of exercise interventions but also the critical role of optimizing exercise prescriptions in managing comorbid depression and cardiovascular disorders. The approach holds important theoretical and clinical practice implications for enhancing both mental and cardiovascular health.https://journals.lww.com/10.4103/hm.HM-D-24-00036cardiovascular diseasedepressionexercise prescriptiontherapeutic targets |
| spellingShingle | Xueqin Li Yumei Han Shi Zhou Jinfang Cheng Advances in Understanding Therapeutic Mechanisms of Exercise Interventions for Individuals with Comorbid Depression and Cardiovascular Diseases: A Narrative Review Heart and Mind cardiovascular disease depression exercise prescription therapeutic targets |
| title | Advances in Understanding Therapeutic Mechanisms of Exercise Interventions for Individuals with Comorbid Depression and Cardiovascular Diseases: A Narrative Review |
| title_full | Advances in Understanding Therapeutic Mechanisms of Exercise Interventions for Individuals with Comorbid Depression and Cardiovascular Diseases: A Narrative Review |
| title_fullStr | Advances in Understanding Therapeutic Mechanisms of Exercise Interventions for Individuals with Comorbid Depression and Cardiovascular Diseases: A Narrative Review |
| title_full_unstemmed | Advances in Understanding Therapeutic Mechanisms of Exercise Interventions for Individuals with Comorbid Depression and Cardiovascular Diseases: A Narrative Review |
| title_short | Advances in Understanding Therapeutic Mechanisms of Exercise Interventions for Individuals with Comorbid Depression and Cardiovascular Diseases: A Narrative Review |
| title_sort | advances in understanding therapeutic mechanisms of exercise interventions for individuals with comorbid depression and cardiovascular diseases a narrative review |
| topic | cardiovascular disease depression exercise prescription therapeutic targets |
| url | https://journals.lww.com/10.4103/hm.HM-D-24-00036 |
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