Oral GVHD post-cardiac xenograft valve replacement: a case report
Abstract Background Graft versus host disease (GVHD) is an autoimmune disease that affects the oral cavity as well as other parts of the body. Oral GVHD occurs in 45–83% of cases, and chronic GVHD observed in 30–50% of cases usually manifests as an oral presentation. Case presentation In this case r...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Journal of Cardiothoracic Surgery |
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| Online Access: | https://doi.org/10.1186/s13019-024-03200-0 |
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| author | Sarah M. Nizar Feteih Mohammad S. Shihata Abdelrazak S. Meliti |
| author_facet | Sarah M. Nizar Feteih Mohammad S. Shihata Abdelrazak S. Meliti |
| author_sort | Sarah M. Nizar Feteih |
| collection | DOAJ |
| description | Abstract Background Graft versus host disease (GVHD) is an autoimmune disease that affects the oral cavity as well as other parts of the body. Oral GVHD occurs in 45–83% of cases, and chronic GVHD observed in 30–50% of cases usually manifests as an oral presentation. Case presentation In this case report, a 13 years-old girl was referred to the periodontics clinic from the pediatric dentistry clinics for proper diagnosis and management of the oral presentations observed after receiving a prosthetic valve replacement 2 years ago. In this study, the xenograft type used was mainly investigated, as similar soft tissue grafts are used in the oral cavity with no GVHD oral manifestations being observed. This brings about an interesting discussion of the use of xenografts in different areas of the human body, but with different presentations. Conclusions Thus, future investigations on early diagnostic tools, including saliva or blood examinations, are needed to create preventive methods or create sensitive testing for early diagnosis in such patients. |
| format | Article |
| id | doaj-art-03d6ccfc3a2042ceb4f9b72db4b18b4b |
| institution | Kabale University |
| issn | 1749-8090 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj-art-03d6ccfc3a2042ceb4f9b72db4b18b4b2024-12-29T12:46:46ZengBMCJournal of Cardiothoracic Surgery1749-80902024-12-011911710.1186/s13019-024-03200-0Oral GVHD post-cardiac xenograft valve replacement: a case reportSarah M. Nizar Feteih0Mohammad S. Shihata1Abdelrazak S. Meliti2Department of Dentistry, Periodontology, King Faisal Specialist Hospital and Research CentreDepartment of Cardiovascular Diseases, Cardiac Surgery, King Faisal Specialist Hospital and Research CentreDepartment of Anatomical Pathology, Pathology, King Faisal Specialist Hospital and Research CentreAbstract Background Graft versus host disease (GVHD) is an autoimmune disease that affects the oral cavity as well as other parts of the body. Oral GVHD occurs in 45–83% of cases, and chronic GVHD observed in 30–50% of cases usually manifests as an oral presentation. Case presentation In this case report, a 13 years-old girl was referred to the periodontics clinic from the pediatric dentistry clinics for proper diagnosis and management of the oral presentations observed after receiving a prosthetic valve replacement 2 years ago. In this study, the xenograft type used was mainly investigated, as similar soft tissue grafts are used in the oral cavity with no GVHD oral manifestations being observed. This brings about an interesting discussion of the use of xenografts in different areas of the human body, but with different presentations. Conclusions Thus, future investigations on early diagnostic tools, including saliva or blood examinations, are needed to create preventive methods or create sensitive testing for early diagnosis in such patients.https://doi.org/10.1186/s13019-024-03200-0Autoimmune diseaseGraft versus host diseaseOral cavityTissue graftsXenografts |
| spellingShingle | Sarah M. Nizar Feteih Mohammad S. Shihata Abdelrazak S. Meliti Oral GVHD post-cardiac xenograft valve replacement: a case report Journal of Cardiothoracic Surgery Autoimmune disease Graft versus host disease Oral cavity Tissue grafts Xenografts |
| title | Oral GVHD post-cardiac xenograft valve replacement: a case report |
| title_full | Oral GVHD post-cardiac xenograft valve replacement: a case report |
| title_fullStr | Oral GVHD post-cardiac xenograft valve replacement: a case report |
| title_full_unstemmed | Oral GVHD post-cardiac xenograft valve replacement: a case report |
| title_short | Oral GVHD post-cardiac xenograft valve replacement: a case report |
| title_sort | oral gvhd post cardiac xenograft valve replacement a case report |
| topic | Autoimmune disease Graft versus host disease Oral cavity Tissue grafts Xenografts |
| url | https://doi.org/10.1186/s13019-024-03200-0 |
| work_keys_str_mv | AT sarahmnizarfeteih oralgvhdpostcardiacxenograftvalvereplacementacasereport AT mohammadsshihata oralgvhdpostcardiacxenograftvalvereplacementacasereport AT abdelrazaksmeliti oralgvhdpostcardiacxenograftvalvereplacementacasereport |