Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice.

Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice.

Whilst data recognise both myeloid cell accumulation during choroidal neovascularisation (CNV) as well as complement activation, none of the data has presented a clear explanation for the angiogenic drive that promotes pathological angiogenesis. One possibility that is a pre-eminent drive is a speci...

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Bibliographic Details
Main Authors: Jian Liu, David A Copland, Shintaro Horie, Wei-Kang Wu, Mei Chen, Yunhe Xu, B Paul Morgan, Matthias Mack, Heping Xu, Lindsay B Nicholson, Andrew D Dick
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0072935
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https://doi.org/10.1371/journal.pone.0072935

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