A convenient synthetic approach to 5-(het)arylhydrazine substituted 1,2,4-triazines

A convenient synthetic approach to 5-(het)arylhydrazine substituted 1,2,4-triazines

A convenient synthesis of 1,2,4-triazines bearing the moieties of (hetero)arylhydrazines at the position of C5 of the 1,2,4-triazine core is reported.

Saved in:

Bibliographic Details
Main Authors:	A. P. Krinochkin, M. R. Guda, A. Rammohan, D. S. Kopchuk, G. V. Zyryanov, V. L. Rusinov, O. N. Chupakhin
Format:	Article
Language:	English
Published:	Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina 2020-12-01
Series:	Chimica Techno Acta
Subjects:	1,2,4-triazines (hetero)arylhydrazines 5-cyano-1,2,4-triazines ipso-substitution
Online Access:	https://chimicatechnoacta.ru/article/view/4635
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Direct synthesis of 5-arylethynyl-1,2,4-triazines via direct CH-functionalization
by: M. I. Savchuk, et al.
Published: (2020-09-01)

The synthesis of 1,2,4-triazines bearing the residues of higher alcohols in the 5-position via the ipso-substitution of cyano group under the solvent-free conditions
by: A. P. Krinochkin, et al.
Published: (2017-09-01)

The activity of pyrazolo[4,3-e][1,2,4]triazine and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulphonamide derivatives in monolayer and spheroid breast cancer cell cultures
by: Anna Szymanowska, et al.
Published: (2024-12-01)

Design, synthesis, α-glucosidase inhibition and hypoglycemic activity of 3-aceto(benzo)hydrazide-1,2,4-triazines as potential anti-diabetic agents
by: Mehdi Valipour, et al.
Published: (2024-12-01)

Direct CH/CH functionalization of 1,3-dihydroxy-9H-xanthen-9-one and 1,3-dimethoxy-9H-xanthen-9-one with 1,2,4-triazines and quinazoline
by: A. D. Sharapov, et al.
Published: (2020-12-01)

New monomers for (bi)pyridine-containing polymers
by: A. P. Krinochkin, et al.
Published: (2020-12-01)

Expedient synthesis of 1,2,4-triazinyl substituted benzo[c]coumarins via double oxidation strategy
by: Ramil F. Fatykhov, et al.
Published: (2023-04-01)

Two mutually complementary synthetic approaches towards 3-substituted 3,4-disubstituted and 1-(2-pyridyl)-substituted isoquinolines
by: I. L. Nikonov, et al.
Published: (2018-10-01)

Determination of pKa of triazolo[5,1-c][1,2,4]triazines in non-aqueous media by potentiometric titration
by: Alexandra V. Ivoilova, et al.
Published: (2024-11-01)

Synthesis of meso-2,2’-bipyridyl-substituted calix[4]arenes and their response to metal cations
by: T. D. Moseev, et al.
Published: (2020-12-01)

Combinatorial approach to the synthesis of substituted 1,2,4-triazines
by: D. N. Kozhevnikov, et al.
Published: (2017-05-01)

An overview of the most used synthetic pathways of 1,2,4-triazolo[1,5-a]pyrimidines
by: Mohamed N. Zedan, et al.
Published: (2024-12-01)

Sulfur Derivatives of 1,2,4-Triazole: Recently Developed Compounds, Structure Activity Relationship, and Biological Activity: Review article
by: Azhar Mahdi Jasim, et al.
Published: (2024-12-01)

2-(Butylamino)-6-chloro-4-[3-(7-chloro-4-quinolylamino)propylamino]-1,3,5-triazine
by: Zimo Ren, et al.
Published: (2024-10-01)

Synthesis of 1,2,4-Oxadiazoles Based on Diffractaic Acid
by: Aleksandr Filimonov, et al.
Published: (2024-11-01)

In vitro antitumor and immunomodulatory activities of 1,2,4-oxadiazole derivatives
by: Héverton Mendes Araújo, et al.
Published: (2025-03-01)

The features of nucleophilic substitution of the nitro group in 4-alkyl-6-nitro-1,2,4-triazolo[5,1-c][1,2,4]triazines
by: E. N. Ulomsky, et al.
Published: (2017-05-01)

In vitro Biological Evaluation of 1,2,4-triazole Mannich Base
by: Mahmood Sherzad Rafaat, et al.
Published: (2023-12-01)

The research of pharmacokinetic parameters and metabolism of sodium 2-((4-amino-5-(thiophen-2-ylmethyl)-4h-1,2,4-triazol-3-yl)thio)acetate for use in military and civilian medicine
by: D. L. Usenko, et al.
Published: (2024-12-01)

Synthesis and characterization of some novel 1,2,4-triazoles, 1,3,4-thiadiazoles and Schiff bases incorporating imidazole moiety as potential antimicrobial agents
by: Aouad Mohamed Reda, et al.
Published: (2015-06-01)

Green ultrasound-assisted three-component click synthesis of novel 1H-1,2,3-triazole carrying benzothiazoles and fluorinated-1,2,4-triazole conjugates and their antimicrobial evaluation
by: Rezki Nadjet, et al.
Published: (2017-09-01)

Synthesis, Characterisation, Theoretical NMR Calculations and Crystal Structure of the 3-methyl-1H-1,2,4?4-triazole-5-amine acetate
by: Patricia Saraiva Vilas Boas Almeida, et al.
Published: (2022-09-01)

Thermodynamic Evaluation of Novel 1,2,4-Triazolium Alanine Ionic Liquids as Sustainable Heat-Transfer Media
by: Kunhao Liang, et al.
Published: (2024-11-01)

Installation of an Indole on the BRCA1 Disordered Domain Using Triazine Chemistry
by: Liam E. Claton, et al.
Published: (2024-12-01)

RuPhos Pd G4: A catalyst for Suzuki-Miyaura coupling reactions involving 1,2,4-oxadiazoles
by: Deepak Kumar, et al.
Published: (2025-01-01)

Synthesis and Antifungal Activity of Fmoc-Protected 1,2,4-Triazolyl-α-Amino Acids and Their Dipeptides Against <i>Aspergillus</i> Species
by: Tatevik Sargsyan, et al.
Published: (2025-01-01)

2,4,6-Tris(p-aminoanilino)-1,3,5-triazine: Synthesis and Electron Paramagnetic Resonance (EPR) Analysis
by: Ziya Erdem Koç, et al.
Published: (2022-12-01)

Search for New Compounds with Anti-Inflammatory Activity Among 1,2,4-Triazole Derivatives
by: Teresa Glomb, et al.
Published: (2024-12-01)

Recent Developments Towards the Synthesis of Triazole Derivatives: A Review
by: Issam Ameziane El Hassani, et al.
Published: (2024-10-01)

Design, Synthesis, Antimicrobial Activity, and Molecular Docking of Novel Thiazoles, Pyrazoles, 1,3-Thiazepinones, and 1,2,4-Triazolopyrimidines Derived from Quinoline-Pyrido[2,3-<i>d</i>] Pyrimidinones
by: Ameen Ali Abu-Hashem, et al.
Published: (2024-12-01)

Molecular docking and molecular dynamics simulation studies of inhibitor candidates against Anopheles gambiae 3-hydroxykynurenine transaminase and implications on vector control
by: Eunice O. Adedeji, et al.
Published: (2025-01-01)

Synthesis and biological evaluation of novel aminoguanidine derivatives as potential antibacterial agents
by: Xueqian Bai, et al.
Published: (2024-11-01)

Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds
by: Maja Karnaš, et al.
Published: (2024-12-01)

Structure optimization and molecular dynamics studies of new tumor-selective s-triazines targeting DNA and MMP-10/13 for halting colorectal and secondary liver cancers
by: Christine A. Morcos, et al.
Published: (2024-12-01)

Density Functional Theory Study on Ring-Chain Isomerism of Semicarbazones
by: Alexander S. Kuvakin, et al.
Published: (2023-11-01)

Crystal structure of the 1:1 cocrystal 5,5′-(triaz-1-ene-1,3-diyl)bis(3-nitro-1H-1,2,4-triazole)–triethylammonium nitrate
by: Matthew Gettings, et al.
Published: (2024-12-01)

(<i>E</i>)-1-(3-(3-Hydroxy-4-Methoxyphenyl)-1-(3,4,5-Trimethoxyphenyl)allyl)-1<i>H</i>-1,2,4-Triazole and Related Compounds: Their Synthesis and Biological Evaluation as Novel Antimitotic Agents Targeting Breast Cancer
by: Gloria Ana, et al.
Published: (2025-01-01)

Guideline for Using Alternative Feedstuffs for Livestock
by: Robert Myer, et al.
Published: (2010-04-01)

Nematode Management for Golf Courses in Florida
by: William T. Crow
Published: (2010-04-01)

Nematode Management for Golf Courses in Florida
by: William T. Crow
Published: (2010-04-01)